5Y1Y | |
5B6G | | PROTEIN-PROTEIN INTERACTION | | Descriptor: | Adenomatous polyposis coli protein, PHQ-ALA-GLY-GLU-ALA-XYC-TYR-GLU, SULFATE ION, ... | | Authors: | Zhao, Y., Jiang, H., Yang, X., Jiang, F., Song, K., Zhang, J. | | Deposit date: | 2016-05-27 | | Release date: | 2017-05-31 | | Last modified: | 2019-01-23 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
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5IZ6 | | PROTEIN-PROTEIN INTERACTION | | Descriptor: | Adenomatous polyposis coli protein, PHQ-ALA-GLY-GLU-ALA-LEU-TYR-GLU-NH2, SULFATE ION, ... | | Authors: | Zhao, Y., Jiang, H., Yang, X., Jiang, F., Song, K., Zhang, J. | | Deposit date: | 2016-03-25 | | Release date: | 2017-07-05 | | Last modified: | 2019-01-23 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
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5IZ8 | | PROTEIN-PROTEIN INTERACTION | | Descriptor: | Adenomatous polyposis coli protein, ACE-ALA-GLY-GLU-ALA-LEU-ALA-ASP-NH2, TRIETHYLENE GLYCOL | | Authors: | Zhao, Y., Jiang, H., Yang, X., Jiang, F., Song, K., Zhang, J. | | Deposit date: | 2016-03-25 | | Release date: | 2017-07-05 | | Last modified: | 2019-01-23 | | Method: | X-RAY DIFFRACTION (3.06 Å) | | Cite: | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
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5IZ9 | | PROTEIN-PROTEIN INTERACTION | | Descriptor: | Adenomatous polyposis coli protein, ACE-GLY-GLY-GLU-ALA-LEU-ALA-ASP-NH2 | | Authors: | Zhao, Y., Jiang, H., Yang, X., Jiang, F., Song, K., Zhang, J. | | Deposit date: | 2016-03-25 | | Release date: | 2017-07-05 | | Last modified: | 2019-01-23 | | Method: | X-RAY DIFFRACTION (2.93 Å) | | Cite: | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
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5IZA | | PROTEIN-PROTEIN INTERACTION | | Descriptor: | Adenomatous polyposis coli protein, ACE-GLY-GLY-GLU-ALA-LEU-ALA-TRP-NH2 | | Authors: | Zhao, Y., Jiang, H., Yang, X., Jiang, F., Song, K., Zhang, J. | | Deposit date: | 2016-03-25 | | Release date: | 2017-07-05 | | Last modified: | 2019-11-20 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
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5XM2 | | HUMAN N-TERMINAL DOMAIN OF FACT COMPLEX SUBUNIT SPT16 | | Descriptor: | FACT complex subunit SPT16, GLYCEROL, DI(HYDROXYETHYL)ETHER | | Authors: | Xu, S., Li, H., Dou, Y., Chen, Y., Jiang, H., Lu, D., Wang, M., Su, D. | | Deposit date: | 2017-05-12 | | Release date: | 2018-05-16 | | Last modified: | 2019-11-27 | | Method: | X-RAY DIFFRACTION (2.187 Å) | | Cite: | The structural basis of human Spt16 N-terminal domain interaction with histone (H3-H4)2tetramer.
Biochem.Biophys.Res.Commun., 508, 2019
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4IAQ | | CRYSTAL STRUCTURE OF THE CHIMERIC PROTEIN OF 5-HT1B-BRIL IN COMPLEX WITH DIHYDROERGOTAMINE (PSI COMMUNITY TARGET) | | Descriptor: | Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Dihydroergotamine | | Authors: | Wang, C., Jiang, Y., Ma, J., Wu, H., Wacker, D., Katritch, V., Han, G.W., Liu, W., Huang, X., Vardy, E., McCorvy, J.D., Gao, X., Zhou, E.X., Melcher, K., Zhang, C., Bai, F., Yang, H., Yang, L., Jiang, H., Roth, B.L., Cherezov, V., Stevens, R.C., Xu, H.E., GPCR Network (GPCR) | | Deposit date: | 2012-12-07 | | Release date: | 2013-03-13 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis for molecular recognition at serotonin receptors.
Science, 340, 2013
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4IAR | | CRYSTAL STRUCTURE OF THE CHIMERIC PROTEIN OF 5-HT1B-BRIL IN COMPLEX WITH ERGOTAMINE (PSI COMMUNITY TARGET) | | Descriptor: | Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Ergotamine, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | | Authors: | Wang, C., Jiang, Y., Ma, J., Wu, H., Wacker, D., Katritch, V., Han, G.W., Liu, W., Huang, X., Vardy, E., McCorvy, J.D., Gao, X., Zhou, E.X., Melcher, K., Zhang, C., Bai, F., Yang, H., Yang, L., Jiang, H., Roth, B.L., Cherezov, V., Stevens, R.C., Xu, H.E., GPCR Network (GPCR) | | Deposit date: | 2012-12-07 | | Release date: | 2013-03-13 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural basis for molecular recognition at serotonin receptors.
Science, 340, 2013
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4ZWJ | | CRYSTAL STRUCTURE OF RHODOPSIN BOUND TO ARRESTIN BY FEMTOSECOND X-RAY LASER | | Descriptor: | Chimera protein of human Rhodopsin, mouse S-arrestin, and T4 Endolysin | | Authors: | Kang, Y., Zhou, X.E., Gao, X., He, Y., Liu, W., Ishchenko, A., Barty, A., White, T.A., Yefanov, O., Han, G.W., Xu, Q., de Waal, P.W., Ke, J., Tan, M.H.E., Zhang, C., Moeller, A., West, G.M., Pascal, B., Eps, N.V., Caro, L.N., Vishnivetskiy, S.A., Lee, R.J., Suino-Powell, K.M., Gu, X., Pal, K., Ma, J., Zhi, X., Boutet, S., Williams, G.J., Messerschmidt, M., Gati, C., Zatsepin, N.A., Wang, D., James, D., Basu, S., Roy-Chowdhury, S., Conrad, C., Coe, J., Liu, H., Lisova, S., Kupitz, C., Grotjohann, I., Fromme, R., Jiang, Y., Tan, M., Yang, H., Li, J., Wang, M., Zheng, Z., Li, D., Howe, N., Zhao, Y., Standfuss, J., Diederichs, K., Dong, Y., Potter, C.S., Carragher, B., Caffrey, M., Jiang, H., Chapman, H.N., Spence, J.C.H., Fromme, P., Weierstall, U., Ernst, O.P., Katritch, V., Gurevich, V.V., Griffin, P.R., Hubbell, W.L., Stevens, R.C., Cherezov, V., Melcher, K., Xu, H.E., GPCR Network (GPCR) | | Deposit date: | 2015-05-19 | | Release date: | 2015-07-29 | | Last modified: | 2018-02-14 | | Method: | X-RAY DIFFRACTION (3.302 Å) | | Cite: | Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.
Nature, 523, 2015
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5XEZ | | STRUCTURE OF THE FULL-LENGTH GLUCAGON CLASS B G PROTEIN-COUPLED RECEPTOR | | Descriptor: | Glucagon receptor,Endolysin,Glucagon receptor, Antibody, mAb1, ... | | Authors: | Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.W., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B. | | Deposit date: | 2017-04-06 | | Release date: | 2017-05-24 | | Last modified: | 2017-06-14 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
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5XF1 | | STRUCTURE OF THE FULL-LENGTH GLUCAGON CLASS B G PROTEIN-COUPLED RECEPTOR | | Descriptor: | Glucagon receptor,Endolysin,Glucagon receptor, Antibody mAb1 Heavy chain, Antibody mAb1 Light chain, ... | | Authors: | Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.W., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B. | | Deposit date: | 2017-04-06 | | Release date: | 2017-05-24 | | Last modified: | 2017-06-14 | | Method: | X-RAY DIFFRACTION (3.19 Å) | | Cite: | Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
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5YQZ | | STRUCTURE OF THE GLUCAGON RECEPTOR IN COMPLEX WITH A GLUCAGON ANALOGUE | | Descriptor: | Glucagon receptor,Endolysin,Glucagon receptor, Glucagon analogue, N-ACETYL-D-GLUCOSAMINE, ... | | Authors: | Zhang, H., Qiao, A., Yang, L., VAN EPS, N., Frederiksen, K., Yang, D., Dai, A., Cai, X., Zhang, H., Yi, C., Can, C., He, L., Yang, H., Lau, J., Ernst, O., Hanson, M., Stevens, R., Wang, M., Seedtz-Runge, S., Jiang, H., Zhao, Q., Wu, B. | | Deposit date: | 2017-11-08 | | Release date: | 2018-01-17 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structure of the glucagon receptor in complex with a glucagon analogue.
Nature, 553, 2018
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3DOY | | CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH COMPOUND 3I | | Descriptor: | (3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ... | | Authors: | Zhang, L., He, L., Liu, X., Liu, H., Shen, X., Jiang, H. | | Deposit date: | 2008-07-07 | | Release date: | 2009-05-05 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J.Med.Chem., 52, 2009
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3DOZ | | CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH COMPOUND 3K | | Descriptor: | (3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ... | | Authors: | Zhang, L., He, L., Liu, X., Liu, H., Shen, X., Jiang, H. | | Deposit date: | 2008-07-07 | | Release date: | 2009-05-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J.Med.Chem., 52, 2009
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3DP0 | | CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH COMPOUND 3M | | Descriptor: | (3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ... | | Authors: | Zhang, L., He, L., Liu, X., Liu, H., Shen, X., Jiang, H. | | Deposit date: | 2008-07-07 | | Release date: | 2009-05-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J.Med.Chem., 52, 2009
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3DP1 | | CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH COMPOUND 3N | | Descriptor: | (3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ... | | Authors: | Zhang, L., He, L., Liu, X., Liu, H., Shen, X., Jiang, H. | | Deposit date: | 2008-07-07 | | Release date: | 2009-05-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J.Med.Chem., 52, 2009
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3DP2 | | CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH COMPOUND 3J | | Descriptor: | (3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ... | | Authors: | Zhang, L., He, L., Liu, X., Liu, H., Shen, X., Jiang, H. | | Deposit date: | 2008-07-07 | | Release date: | 2009-05-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J.Med.Chem., 52, 2009
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3DP3 | | CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH COMPOUND 3Q | | Descriptor: | (3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ... | | Authors: | Zhang, L., He, L., Liu, X., Liu, H., Shen, X., Jiang, H. | | Deposit date: | 2008-07-07 | | Release date: | 2009-05-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J.Med.Chem., 52, 2009
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3NSP | | CRYSTAL STRUCTURE OF TETRAMERIC RXRALPHA-LBD | | Descriptor: | Retinoid X receptor, alpha | | Authors: | Zhang, H., Hu, T., Li, L., Zhou, R., Chen, L., Hu, L., Jiang, H., Shen, X. | | Deposit date: | 2010-07-02 | | Release date: | 2010-11-17 | | Last modified: | 2012-04-11 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
J.Biol.Chem., 286, 2011
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3NSQ | | CRYSTAL STRUCTURE OF TETRAMERIC RXRALPHA-LBD COMPLEXED WITH ANTAGONIST DANTHRON | | Descriptor: | Retinoid X receptor, alpha, 1,8-dihydroxyanthracene-9,10-dione | | Authors: | Zhang, H., Hu, T., Li, L., Zhou, R., Chen, L., Hu, L., Jiang, H., Shen, X. | | Deposit date: | 2010-07-02 | | Release date: | 2010-11-17 | | Last modified: | 2012-04-11 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
J.Biol.Chem., 286, 2011
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3PCU | | CRYSTAL STRUCTURE OF HUMAN RETINOIC X RECEPTOR ALPHA LIGAND-BINDING DOMAIN COMPLEXED WITH LX0278 AND SRC1 PEPTIDE | | Descriptor: | Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 2-[(2S)-6-(2-methylbut-3-en-2-yl)-7-oxo-2,3-dihydro-7H-furo[3,2-g]chromen-2-yl]propan-2-yl acetate | | Authors: | Zhang, H., Zhang, Y., Shen, H., Chen, J., Li, C., Chen, L., Hu, L., Jiang, H., Shen, X. | | Deposit date: | 2010-10-22 | | Release date: | 2011-11-16 | | Last modified: | 2012-04-11 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | (+)-Rutamarin as a Dual Inducer of Both GLUT4 Translocation and Expression Efficiently Ameliorates Glucose Homeostasis in Insulin-Resistant Mice.
Plos One, 7, 2012
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2JR8 | | SOLUTION STRUCTURE OF MANDUCA SEXTA MORICIN | | Descriptor: | Antimicrobial peptide moricin | | Authors: | Gong, Y., Dai, H., Rayaprolu, S., Huang, R., Prakash, O., Jiang, H. | | Deposit date: | 2007-06-21 | | Release date: | 2008-03-25 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Solution structure, antibacterial activity, and expression profile of Manduca sexta moricin.
J.Pept.Sci., 14, 2008
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3DZF | | CRYSTAL STRUCTURE OF HUMAN CD38 EXTRACELLULAR DOMAIN COMPLEXED WITH A COVALENT INTERMEDIATE, ARA-F-RIBOSE-5'-PHOSPHATE | | Descriptor: | ADP-ribosyl cyclase 1, 2-deoxy-2-fluoro-5-O-phosphono-alpha-D-arabinofuranose | | Authors: | Liu, Q., Kriksunov, I.A., Jiang, H., Graeff, R., Lin, H., Lee, H.C., Hao, Q. | | Deposit date: | 2008-07-29 | | Release date: | 2008-11-04 | | Last modified: | 2016-06-08 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
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3DZG | | CRYSTAL STRUCTURE OF HUMAN CD38 EXTRACELLULAR DOMAIN, ARA-F-RIBOSE-5'-PHOSPHATE/NICOTINAMIDE COMPLEX | | Descriptor: | ADP-ribosyl cyclase 1, 2-deoxy-2-fluoro-5-O-phosphono-alpha-D-arabinofuranose, NICOTINAMIDE | | Authors: | Liu, Q., Kriksunov, I.A., Jiang, H., Graeff, R., Lin, H., Lee, H.C., Hao, Q. | | Deposit date: | 2008-07-29 | | Release date: | 2008-11-04 | | Last modified: | 2016-06-08 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Covalent and Noncovalent Intermediates of an NAD Utilizing Enzyme, Human CD38.
Chem.Biol., 15, 2008
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