Summary for 9E6C
| Entry DOI | 10.2210/pdb9e6c/pdb |
| EMDB information | 47555 |
| Descriptor | Chemotactile receptor CRT1, 2-acetamido-2-deoxy-beta-D-glucopyranose, 1-methyl-9H-pyrido[3,4-b]indole-3-carboxylic acid (3 entities in total) |
| Functional Keywords | complex, membrane protein |
| Biological source | Octopus bimaculoides (California two-spot octopus) |
| Total number of polymer chains | 5 |
| Total formula weight | 242226.63 |
| Authors | |
| Primary citation | Sepela, R.J.,Jiang, H.,Shin, Y.H.,Hautala, T.L.,Clardy, J.,Hibbs, R.E.,Bellono, N.W. Environmental microbiomes drive chemotactile sensation in octopus. Cell, 2025 Cited by PubMed Abstract: Microbial communities coat nearly every surface in the environment and have co-existed with animals throughout evolution. Whether animals exploit omnipresent microbial cues to navigate their surroundings is not well understood. Octopuses use "taste-by-touch" chemotactile receptors (CRs) to explore the seafloor, but how they distinguish meaningful surfaces from the rocks and crevices they encounter is unknown. Here, we report that secreted signals from microbiomes of ecologically relevant surfaces activate CRs to guide octopus behavior. Distinct molecules isolated from individual bacterial strains located on prey or eggs bind single CRs in subtly different structural conformations to elicit specific mechanisms of receptor activation, ion permeation and signal transduction, and maternal care and predation behavior. Thus, microbiomes on ecological surfaces act at the level of primary sensory receptors to inform behavior. Our study demonstrates that uncovering interkingdom interactions is essential to understanding how animal sensory systems evolved in a microbe-rich world. PubMed: 40532695DOI: 10.1016/j.cell.2025.05.033 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.04 Å) |
Structure validation
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