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1HDX
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THREE-DIMENSIONAL STRUCTURES OF THREE HUMAN ALCOHOL DEHYDROGENASE VARIANTS: CORRELATIONS WITH THEIR FUNCTIONAL DIFFERENCES
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Hurley, T.D., Amzel, L.M.
Deposit date:1993-10-15
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences.
J.Mol.Biol., 239, 1994
1HDY
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THREE-DIMENSIONAL STRUCTURES OF THREE HUMAN ALCOHOL DEHYDROGENASE VARIANTS: CORRELATIONS WITH THEIR FUNCTIONAL DIFFERENCES
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Hurley, T.D., Amzel, L.M.
Deposit date:1993-10-15
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences.
J.Mol.Biol., 239, 1994
1HDZ
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THREE-DIMENSIONAL STRUCTURES OF THREE HUMAN ALCOHOL DEHYDROGENASE VARIANTS: CORRELATIONS WITH THEIR FUNCTIONAL DIFFERENCES
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Hurley, T.D., Amzel, L.M.
Deposit date:1993-10-15
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences.
J.Mol.Biol., 239, 1994
1O05
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APO FORM OF HUMAN MITOCHONDRIAL ALDEHYDE DEHYDROGENASE
Descriptor:Aldehyde dehydrogenase, SODIUM ION
Authors:Hurley, T.D., Perez-Miller, S., Breen, H.
Deposit date:2003-02-20
Release date:2003-03-04
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Order and disorder in mitochondrial aldehyde dehydrogenase
Chem.Biol.Interact., 130-132, 2001
1ZCT
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STRUCTURE OF GLYCOGENIN TRUNCATED AT RESIDUE 270 IN A COMPLEX WITH UDP
Descriptor:Glycogenin-1, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE
Authors:Hurley, T.D., Stout, S.L., Miner, E., Zhou, J., Roach, P.J.
Deposit date:2005-04-13
Release date:2005-04-26
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Requirements for catalysis in mammalian glycogenin.
J.Biol.Chem., 280, 2005
1ZCU
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APO FORM OF THE 162S MUTANT OF GLYCOGENIN
Descriptor:Glycogenin-1
Authors:Hurley, T.D., Stout, S.L., Miner, E., Zhou, J., Roach, P.J.
Deposit date:2005-04-13
Release date:2005-04-26
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Requirements for catalysis in mammalian glycogenin.
J.Biol.Chem., 280, 2005
1ZCV
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APO FORM OF A MUTANT OF GLYCOGENIN IN WHICH ASP159 IS REPLACED BY ASN
Descriptor:Glycogenin-1, SULFATE ION
Authors:Hurley, T.D., Stout, S.L., Miner, E., Zhou, J., Roach, P.J.
Deposit date:2005-04-13
Release date:2005-04-26
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Requirements for catalysis in mammalian glycogenin.
J.Biol.Chem., 280, 2005
1ZCY
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APO FORM OF A MUTANT OF GLYCOGENIN IN WHICH ASP159 IS REPLACED BY SER
Descriptor:Glycogenin-1, SULFATE ION
Authors:Hurley, T.D., Stout, S.L., Miner, E., Zhou, J., Roach, P.J.
Deposit date:2005-04-13
Release date:2005-04-26
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Requirements for catalysis in mammalian glycogenin.
J.Biol.Chem., 280, 2005
1ZDF
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SER162 MUTANT OF GLYCOGENIN COMPLEXED WITH UDP-GLUCOSE AND MANGANESE
Descriptor:Glycogenin-1, MANGANESE (II) ION, SULFATE ION, ...
Authors:Hurley, T.D., Stout, S.L., Miner, E., Zhou, J., Roach, P.J.
Deposit date:2005-04-14
Release date:2005-04-26
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Requirements for catalysis in mammalian glycogenin.
J.Biol.Chem., 280, 2005
1ZDG
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SER159 MUTANT OF GLYCOGENIN COMPLEXED WITH UDP-GLUCOSE AND MANGANESE
Descriptor:Glycogenin-1, MANGANESE (II) ION, SULFATE ION, ...
Authors:Hurley, T.D., Stout, S.L., Miner, E., Zhou, J., Roach, P.J.
Deposit date:2005-04-14
Release date:2005-04-26
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Requirements for catalysis in mammalian glycogenin.
J.Biol.Chem., 280, 2005
2O8A
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RAT PP1CGAMMA COMPLEXED WITH MOUSE INHIBITOR-2
Descriptor:Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, Protein phosphatase inhibitor 2
Authors:Hurley, T.D.
Deposit date:2006-12-12
Release date:2007-07-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structural basis for regulation of protein phosphatase 1 by inhibitor-2.
J.Biol.Chem., 282, 2007
2O8G
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RAT PP1C GAMMA COMPLEXED WITH MOUSE INHIBITOR-2
Descriptor:Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, Protein phosphatase inhibitor 2, MANGANESE (II) ION
Authors:Hurley, T.D.
Deposit date:2006-12-12
Release date:2007-07-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for regulation of protein phosphatase 1 by inhibitor-2.
J.Biol.Chem., 282, 2007
3HUD
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THE STRUCTURE OF HUMAN BETA 1 BETA 1 ALCOHOL DEHYDROGENASE: CATALYTIC EFFECTS OF NON-ACTIVE-SITE SUBSTITUTIONS
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Hurley, T.D., Bosron, W.F., Hamilton, J.A., Amzel, L.M.
Deposit date:1993-01-04
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions.
Proc.Natl.Acad.Sci.USA, 88, 1991
1DEH
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CRYSTALLIZATION OF HUMAN BETA1 ALCOHOL DEHYDROGENASE (15 MG/ML) IN 50 MM SODIUM PHOSPHATE (PH 7.5), 2.0 MM NAD+ AND 1 MM 4-IODOPYRAZOLE AT 25 OC, 13% (W/V) PEG 8000
Descriptor:HUMAN BETA1 ALCOHOL DEHYDROGENASE, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Hurley, T.D., Davis, G.J.
Deposit date:1995-10-14
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray structure of human beta3beta3 alcohol dehydrogenase. The contribution of ionic interactions to coenzyme binding.
J.Biol.Chem., 271, 1996
1HTB
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CRYSTALLIZATION OF HUMAN BETA3 ALCOHOL DEHYDROGENASE (10 MG/ML) IN 100 MM SODIUM PHOSPHATE (PH 7.5), 7.5 MM NAD+ AND 1 MM 4-IODOPYRAZOLE AT 25 C
Descriptor:BETA3 ALCOHOL DEHYDROGENASE, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Hurley, T.D., Davis, G.J.
Deposit date:1995-08-10
Release date:1995-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray structure of human beta3beta3 alcohol dehydrogenase. The contribution of ionic interactions to coenzyme binding.
J.Biol.Chem., 271, 1996
1AGN
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X-RAY STRUCTURE OF HUMAN SIGMA ALCOHOL DEHYDROGENASE
Descriptor:HUMAN SIGMA ALCOHOL DEHYDROGENASE, ZINC ION, ACETATE ION, ...
Authors:Hurley, T.D., Xie, P.
Deposit date:1996-06-04
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity.
J.Biol.Chem., 272, 1997
2HZY
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MOUSE FUMARYLACETOACETATE HYDROLASE COMPLEXES WITH A TRANSITION-STATE MIMIC OF THE COMPLETE SUBSTRATE
Descriptor:Fumarylacetoacetase, SODIUM ION, MANGANESE (II) ION, ...
Authors:Hurley, T.D., Timm, D.E.
Deposit date:2006-08-09
Release date:2006-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics.
Biochem.J., 402, 2007
4H80
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CRYSTAL STRUCTURE OF HUMAN ALDH3A1 WITH ITS ISOZYME SELECTIVE INHIBITOR - N-[4-(4-METHYLSULFONYL-2-NITROANILINO)PHENYL]ACETAMIDE
Descriptor:Aldehyde dehydrogenase, dimeric NADP-preferring, N-(4-{[4-(methylsulfonyl)-2-nitrophenyl]amino}phenyl)acetamide
Authors:Hurley, T.D., Parajuli, B.
Deposit date:2012-09-21
Release date:2013-12-25
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Kinetic and Structural Characterization of a Selective Inhibitor for Human ALDH3A1
To be Published
4KWF
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CRYSTAL STRUCTURE ANALYSIS OF ALDH2+ALDIB33
Descriptor:Aldehyde dehydrogenase, mitochondrial, 1-benzyl-1H-indole-2,3-dione, ...
Authors:Hurley, T.D., Kimble-Hill, A.C.
Deposit date:2013-05-24
Release date:2014-04-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones.
J.Med.Chem., 57, 2014
4KWG
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CRYSTAL STRUCTURE ANALYSIS OF ALDH2+ALDIB13
Descriptor:Aldehyde dehydrogenase, mitochondrial, 7-bromo-5-methyl-1H-indole-2,3-dione, ...
Authors:Hurley, T.D., Kimble-Hill, A.C.
Deposit date:2013-05-24
Release date:2014-04-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones.
J.Med.Chem., 57, 2014
4KYT
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THE STRUCTURE OF SUPERINHIBITORY PHOSPHOLAMBAN BOUND TO THE CALCIUM PUMP SERCA1A
Descriptor:SERCA1a, Cardiac phospholamban, MALTOSE, ...
Authors:Hurley, T.D., Akin, B.L., Jones, L.R.
Deposit date:2013-05-29
Release date:2013-09-04
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (2.833 Å)
Cite:The structural basis for phospholamban inhibition of the calcium pump in sarcoplasmic reticulum.
J.Biol.Chem., 288, 2013
4L1O
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CRYSTAL STRUCTURE OF HUMAN ALDH3A1 WITH INHIBITOR 1-{[4-(1,3-BENZODIOXOL-5-YLMETHYL)PIPERAZIN-1-YL]METHYL}-1H-INDOLE-2,3-DIONE
Descriptor:Aldehyde dehydrogenase, (3S)-1-{[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]methyl}-3-hydroxy-1,3-dihydro-2H-indol-2-one, POTASSIUM ION, ...
Authors:Hurley, T.D., Parajuli, B.
Deposit date:2013-06-03
Release date:2014-04-16
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of indole-2,3-diones as novel class of inhibitors for ALDH isozymes.
To be Published
4L2O
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CRYSTAL STRUCTURE OF HUMAN ALDH3A1 WITH ITS SELECTIVE INHIBITOR 1-(4-FLUOROPHENYL)SULFONYL-2-METHYLBENZIMIDAZOLE
Descriptor:Aldehyde dehydrogenase, POTASSIUM ION, ACETATE ION, ...
Authors:Hurley, T.D., Parajuli, B.
Deposit date:2013-06-04
Release date:2014-01-29
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (1.937 Å)
Cite:Crystal structure of human ALDH3A1 with its selective inhibitor 1-(4-fluorophenyl)sulfonyl-2-methylbenzimidazole
J.Med.Chem., 2014
4V6B
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CRYSTAL STRUCTURE OF HUMAN FERRITIN PHE167SERFSX26 MUTANT.
Descriptor:Ferritin, CALCIUM ION
Authors:Hurley, T.D., Vidal, R.
Deposit date:2009-06-19
Release date:2014-07-09
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Unraveling of the E-helices and disruption of 4-fold pores are associated with iron mishandling in a mutant ferritin causing neurodegeneration
J.Biol.Chem., 285, 2010
4Y3U
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THE STRUCTURE OF PHOSPHOLAMBAN BOUND TO THE CALCIUM PUMP SERCA1A
Descriptor:Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, Cardiac phospholamban, POTASSIUM ION
Authors:Hurley, T.D.
Deposit date:2015-02-10
Release date:2015-02-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.51 Å)
Cite:The structural basis for phospholamban inhibition of the calcium pump in sarcoplasmic reticulum.
J. Biol. Chem., 288, 2013