4H80

Crystal structure of human ALDH3A1 with its isozyme selective inhibitor - N-[4-(4-methylsulfonyl-2-nitroanilino)phenyl]acetamide

Summary for 4H80

• Entry DOI: 10.2210/pdb4h80/pdb
• Related: 3SZA 3SZB
• Descriptor: Aldehyde dehydrogenase, dimeric NADP-preferring, N-(4-{[4-(methylsulfonyl)-2-nitrophenyl]amino}phenyl)acetamide (3 entities in total)
• Functional Keywords: catalyzes benzaldehyde, rossmann fold, dehydrogenase, nadp+ binding, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P30838
• Total number of polymer chains: 8
• Total formula weight: 420760.80

Authors

Hurley, T.D.,Parajuli, B. (deposition date: 2012-09-21, release date: 2013-12-25, Last modification date: 2023-09-20)

• Primary citation: Parajuli, B.,Georgiadis, T.,Fishel, M.L.,Hurley, T.D.; Kinetic and Structural Characterization of a Selective Inhibitor for Human ALDH3A1; To be Published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)