Author results

5NWP
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CRYSTAL STRUCTURE OF THE LECTIN DOMAIN FROM THE F17-LIKE ADHESIN, UCLD
Descriptor:Adhesin, SULFATE ION
Authors:Ruer, S., Remaut, H.
Deposit date:2017-05-08
Release date:2017-06-21
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.
Nature, 546, 2017
6ARO
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F9 PILUS ADHESIN FMLH LECTIN DOMAIN FROM E. COLI UTI89 CO-CRYSTALLIZED WITH 8-HYDROXYQUINOLINE BETA-GALACTOSIDE
Descriptor:F9 pilus adhesin FmlH, quinolin-8-yl beta-D-galactopyranoside, SULFATE ION
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2017-08-23
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:F9 pilus adhesin FmlH lectin domain from E. coli UTI89 co-crystallized with 8-hydroxyquinoline beta-galactoside
To Be Published
6ARN
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F9 PILUS ADHESIN FMLH LECTIN DOMAIN FROM E. COLI UTI89 CO-CRYSTALLIZED WITH O-METHOXYPHENYL BETA-GALACTOSIDE (OMPG)
Descriptor:Putative Fml fimbrial adhesin FmlD, 2-methoxyphenyl beta-D-galactopyranoside, SULFATE ION
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2017-08-22
Release date:2018-02-28
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:F9 pilus adhesin FmlH lectin domain from E. coli UTI89 co-crystallized with o-methoxyphenyl beta-galactoside (OMPG)
To Be Published
6ARM
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F9 PILUS ADHESIN FMLH LECTIN DOMAIN FROM E. COLI UTI89 CO-CRYSTALLIZED WITH O-NITROPHENYL BETA-GALACTOSIDE (ONPG)
Descriptor:F9 pilus adhesin FmlH, 1-O-[O-NITROPHENYL]-BETA-D-GALACTOPYRANOSE, SULFATE ION
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2017-08-22
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:F9 pilus adhesin FmlH lectin domain from E. coli UTI89 co-crystallized with o-nitrophenyl beta-galactoside (ONPG)
To Be Published
5VQ5
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CRYSTAL STRUCTURE OF THE LECTIN DOMAIN FROM THE F17-LIKE ADHESIN, UCLD
Descriptor:Adhesin, IODIDE ION
Authors:Klein, R.D., Spaulding, C.N., Dodson, K.W., Pinkner, J.S., Hultgren, S.J., Fremont, D.
Deposit date:2017-05-08
Release date:2017-05-24
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.
Nature, 546, 2017
6AOW
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CRYSTAL STRUCTURE OF LECTIN DOMAIN OF F9 PILUS ADHESIN FMLH FROM E. COLI UTI89
Descriptor:F9 pilus adhesin FmlH, SULFATE ION
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2017-08-16
Release date:2018-02-28
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of lectin domain of F9 pilus adhesin FmlH from E. coli UTI89
To Be Published
5F2F
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CRYSTAL STRUCTURE OF PARA-BIPHENYL-2-METHYL-3', 5' DI-METHYL AMIDE MANNOSIDE BOUND TO FIMH LECTIN DOMAIN
Descriptor:Protein FimH, 5-[4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-methyl-phenyl]-~{N}1,~{N}3-dimethyl-benzene-1,3-dicarboxamide, GLYCEROL
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2015-12-01
Release date:2016-05-04
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.665 Å)
Cite:Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI.
Chemmedchem, 11, 2016
1UWF
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1.7 A RESOLUTION STRUCTURE OF THE RECEPTOR BINDING DOMAIN OF THE FIMH ADHESIN FROM UROPATHOGENIC E. COLI
Descriptor:FIMH PROTEIN, BUTYL ALPHA-D-MANNOPYRANOSIDE, GLYCEROL
Authors:Bouckaert, J., Berglund, J., Genst, E.D., Cools, L., Hung, C.-S., Wuhrer, M., Zavialov, A., Langermann, S., Hultgren, S., Wyns, L., Oscarson, S., Knight, S.D., De Greve, H.
Deposit date:2004-02-05
Release date:2005-02-16
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Receptor Binding Studies Disclose a Novel Class of High-Affinity Inhibitors of the Escherichia Coli Fimh Adhesin.
Mol.Microbiol., 55, 2005
5F3F
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CRYSTAL STRUCTURE OF PARA-BIPHENYL-2-METHYL-3'-METHYL AMIDE MANNOSIDE BOUND TO FIMH LECTIN DOMAIN
Descriptor:Protein FimH, 3-[4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-methyl-phenyl]-~{N}-methyl-benzamide
Authors:Klein, R.D., Hultgren, S.J.
Deposit date:2015-12-02
Release date:2016-12-07
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Antibiotic-sparing therapy against gram-negative UPEC bacteria: Potent anti-virulence activity of FimH C-mannoside antagonists
To Be Published
2CO3
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SALMONELLA ENTERICA SAFA PILIN, HEAD-TO-TAIL SWAPPED DIMER OF NTD1 MUTANT
Descriptor:SAFA PILUS SUBUNIT
Authors:Remaut, H., Rose, R.J., Hannan, T.J., Hultgren, S.J., Radford, S.E., Ashcroft, A.E., Waksman, G.
Deposit date:2006-05-25
Release date:2006-06-27
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Donor-Strand Exchange in Chaperone-Assisted Pilus Assembly Proceeds Through a Concerted Beta-Strand Displacement Mechanism
Mol.Cell, 22, 2006
1J8R
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BINARY COMPLEX OF THE PAPG RECEPTOR-BINDING DOMAIN BOUND TO GBO4 RECEPTOR
Descriptor:PYELONEPHRITIC ADHESIN, N-ACETYL-D-GALACTOSAMINE, ALPHA D-GALACTOSE, ...
Authors:Dodson, K.W., Pinkner, J.S., Rose, T., Magnusson, G., Hultgren, S.J., Waksman, G., Midwest Center for Structural Genomics (MCSG)
Deposit date:2001-05-22
Release date:2001-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor.
Cell(Cambridge,Mass.), 105, 2001
2CNZ
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SALMONELLA ENTERICA SAFA PILIN IN COMPLEX WITH A 19-RESIDUE SAFA NTE PEPTIDE (V13A MUTANT)
Descriptor:PUTATIVE OUTER MEMBRANE PROTEIN
Authors:Remaut, H., Rose, R.J., Hannan, T.J., Hultgren, S.J., Radford, S.E., Ashcroft, A.E., Waksman, G.
Deposit date:2006-05-25
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Donor-Strand Exchange in Chaperone-Assisted Pilus Assembly Proceeds Through a Concerted Beta-Strand Displacement Mechanism
Mol.Cell, 22, 2006
2CO7
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SALMONELLA ENTERICA SAFA PILIN IN COMPLEX WITH THE SAFB CHAPERONE (TYPE II)
Descriptor:SAFA PILUS SUBUNIT, PUTATIVE FIMBRIAE ASSEMBLY CHAPERONE, SULFATE ION
Authors:Remaut, H., Rose, R.J., Hannan, T.J., Hultgren, S.J., Radford, S.E., Ashcroft, A.E., Waksman, G.
Deposit date:2006-05-25
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Donor-Strand Exchange in Chaperone-Assisted Pilus Assembly Proceeds Through a Concerted Beta-Strand Displacement Mechanism
Mol.Cell, 22, 2006
6AOY
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F9 PILUS ADHESIN FMLH LECTIN DOMAIN FROM E. COLI UTI89 CO-CRYSTALLIZED WITH O-NITROPHENYL BETA-GALACTOSIDE (ONPG)
Descriptor:Fml fimbrial adhesin FmlD, SULFATE ION, 1-O-[O-NITROPHENYL]-BETA-D-GALACTOPYRANOSE
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2017-08-16
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of lectin domain of F9 pilus adhesin FmlH from E. coli UTI89 bound to o-nitrophenyl beta-galactoside (ONPG)
To Be Published
2CO4
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SALMONELLA ENTERICA SAFA PILIN IN COMPLEX WITH A 19-RESIDUE SAFA NTE PEPTIDE
Descriptor:PUTATIVE OUTER MEMBRANE PROTEIN
Authors:Remaut, H., Rose, R.J., Hannan, T.J., Hultgren, S.J., Radford, S.E., Ashcroft, A.E., Waksman, G.
Deposit date:2006-05-25
Release date:2006-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Donor-Strand Exchange in Chaperone-Assisted Pilus Assembly Proceeds Through a Concerted Beta-Strand Displacement Mechanism
Mol.Cell, 22, 2006
1N12
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CRYSTAL STRUCTURE OF THE PAPE (N-TERMINAL-DELETED) PILUS SUBUNIT BOUND TO A PEPTIDE CORRESPONDING TO THE N-TERMINAL EXTENSION OF THE PAPK PILUS SUBUNIT (RESIDUES 1-11) FROM UROPATHOGENIC E. COLI
Descriptor:mature Fimbrial protein PapE, Peptide corresponding to the N-terminal extension of protein PapK
Authors:Sauer, F.G., Pinkner, J.S., Waksman, G., Hultgren, S.J.
Deposit date:2002-10-16
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation
Cell(Cambridge,Mass.), 111, 2002
2CNY
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SALMONELLA ENTERICA SAFA PILIN IN COMPLEX WITH A 19-RESIDUE SAFA NTE PEPTIDE (I15A MUTANT)
Descriptor:PUTATIVE OUTER MEMBRANE PROTEIN
Authors:Remaut, H., Rose, R.J., Hannan, T.J., Hultgren, S.J., Radford, S.E., Ashcroft, A.E., Waksman, G.
Deposit date:2006-05-25
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Donor-Strand Exchange in Chaperone-Assisted Pilus Assembly Proceeds Through a Concerted Beta-Strand Displacement Mechanism
Mol.Cell, 22, 2006
5JQI
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CRYSTAL STRUCTURE OF FIMH A62S FROM E. COLI UTI89 BOUND TO FIMG N-TERMINAL EXTENSION
Descriptor:FimG N-terminal extension, Type 1 fimbiral adhesin FimH, GLYCEROL
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2016-05-05
Release date:2017-02-22
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.962 Å)
Cite:Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions.
Sci Adv, 3, 2017
2CO6
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SALMONELLA ENTERICA SAFA PILIN IN COMPLEX WITH THE SAFB CHAPERONE (TYPE I)
Descriptor:PUTATIVE OUTER MEMBRANE PROTEIN, PUTATIVE FIMBRIAE ASSEMBLY CHAPERONE
Authors:Remaut, H., Rose, R.J., Hannan, T.J., Hultgren, S.J., Radford, S.E., Ashcroft, A.E., Waksman, G.
Deposit date:2006-05-25
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Donor-Strand Exchange in Chaperone-Assisted Pilus Assembly Proceeds Through a Concerted Beta-Strand Displacement Mechanism
Mol.Cell, 22, 2006
2XG5
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E. COLI P PILUS CHAPERONE-SUBUNIT COMPLEX PAPD-PAPH BOUND TO PILUS BIOGENESIS INHIBITOR, PILICIDE 5D
Descriptor:CHAPERONE PROTEIN PAPD, PAP FIMBRIAL MINOR PILIN PROTEIN, GLYCEROL, ...
Authors:Remaut, H., Phan, G., Buelens, F., Chorell, E., Pinkner, J.S., Edvinsson, S., Almqvist, F., Hultgren, S.J., Waksman, G.
Deposit date:2010-05-30
Release date:2010-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity.
J.Med.Chem., 53, 2010
3ME0
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STRUCTURE OF THE E. COLI CHAPERONE PAPD IN COMPLEX WITH THE PILIN DOMAIN OF THE PAPGII ADHESIN
Descriptor:Chaperone protein papD, PapG protein
Authors:Ford, B.A., Elam, J.S., Dodson, K.W., Pinkner, J.S., Hultgren, S.J.
Deposit date:2010-03-31
Release date:2011-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structure of the E. Coli Chaperone PapD in Complex with the Pilin Domain of the PapGII Adhesin
To be Published
5LNG
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LECTIN DOMAIN OF E. COLI F9 PILUS ADHESIN FMLH
Descriptor:Putative Fml fimbrial adhesin FmlD, SULFATE ION
Authors:Ruer, S., Conover, M.S., Kalas, V., Taganna, J., De Greve, H., Pinkner, J.S., Dodson, K.W., Hultgren, S.J., Remaut, H.
Deposit date:2016-08-04
Release date:2016-10-05
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection.
Cell Host Microbe, 20, 2016
1J8S
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PAPG ADHESIN RECEPTOR BINDING DOMAIN-UNBOUND FORM
Descriptor:PYELONEPHRITIC ADHESIN
Authors:Dodson, K.W., Pinkner, J.S., Rose, T., Magnusson, G., Hultgren, S.J., Waksman, G.
Deposit date:2001-05-22
Release date:2001-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor.
Cell(Cambridge,Mass.), 105, 2001
1TR7
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FIMH ADHESIN RECEPTOR BINDING DOMAIN FROM UROPATHOGENIC E. COLI
Descriptor:FimH protein, BUTYL ALPHA-D-MANNOPYRANOSIDE, CACODYLATE ION, ...
Authors:Bouckaert, J., Berglund, J., Schembri, M., De Genst, E., Cools, L., Wuhrer, M., Hung, C.S., Pinkner, J., Slattegard, R., Zavialov, A., Choudhury, D., Langermann, S., Hultgren, S.J., Wyns, L., Klemm, P., Oscarson, S., Knight, S.D., De Greve, H.
Deposit date:2004-06-21
Release date:2005-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin
Mol.Microbiol., 55, 2005
2VCO
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CRYSTAL STRUCTURE OF THE FIMBRIAL ADHESIN FIMH IN COMPLEX WITH ITS HIGH-MANNOSE EPITOPE
Descriptor:PROTEIN FIMH, NICKEL (II) ION, SULFATE ION, ...
Authors:Wellens, A., Garofalo, C., Nguyen, H., Wyns, L., De Greve, H., Hultgren, S.J., Bouckaert, J.
Deposit date:2007-09-26
Release date:2008-05-13
Last modified:2012-05-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Intervening with Urinary Tract Infections Using Anti-Adhesives Based on the Crystal Structure of the Fimh-Oligomannose-3 Complex.
Plos One, 3, 2008
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