1TR7

FimH adhesin receptor binding domain from uropathogenic E. coli

Summary for 1TR7

Related1UWF
DescriptorFimH protein, BUTYL ALPHA-D-MANNOPYRANOSIDE, CACODYLATE ION, ... (5 entities in total)
Functional Keywordstype-1 pili, adhesion, urinary tract infections, uropathogenic e. coli, carbohydrate binding, cell adhesion
Biological sourceEscherichia coli
Cellular locationFimbrium P08191
Total number of polymer chains2
Total molecular weight36219.1
Authors
Primary citation
Bouckaert, J.,Berglund, J.,Schembri, M.,De Genst, E.,Cools, L.,Wuhrer, M.,Hung, C.S.,Pinkner, J.,Slattegard, R.,Zavialov, A.,Choudhury, D.,Langermann, S.,Hultgren, S.J.,Wyns, L.,Klemm, P.,Oscarson, S.,Knight, S.D.,De Greve, H.
Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin
Mol.Microbiol., 55:441-455, 2005
PubMed: 15659162 (PDB entries with the same primary citation)
DOI: 10.1111/j.1365-2958.2004.04415.x
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.20740.3%4.5%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1tr7
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Molmil generated image of 1tr7
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More Biological unit images

Molmil generated image of 1tr7
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Molmil generated image of 1tr7
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1tr7.pdb1.gz [28.12 KB])
Coordinate files for Biological unit (1tr7.pdb2.gz [28.69 KB])