6MAP
F9 Pilus Adhesin FmlH Lectin Domain from E. coli UTI89 in Complex with Galactoside 5-nitro-2'-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-[1,1'-biphenyl]-3-carboxylic acid
Summary for 6MAP
Entry DOI | 10.2210/pdb6map/pdb |
Descriptor | Fimbrial adhesin FmlD, SULFATE ION, 2'-(beta-D-galactopyranosyloxy)-5-nitro[1,1'-biphenyl]-3-carboxylic acid, ... (5 entities in total) |
Functional Keywords | pilus, adhesin, galactose, lectin, sugar binding protein, sugar binding protein-inhibitor complex, sugar binding protein/inhibitor |
Biological source | Escherichia coli UTI89 |
Total number of polymer chains | 1 |
Total formula weight | 19139.11 |
Authors | Klein, R.D.,Hultgren, S.J. (deposition date: 2018-08-28, release date: 2019-09-04, Last modification date: 2023-12-13) |
Primary citation | Maddirala, A.R.,Klein, R.,Pinkner, J.S.,Kalas, V.,Hultgren, S.J.,Janetka, J.W. Biphenyl Gal and GalNAc FmlH Lectin Antagonists of Uropathogenic E. coli (UPEC): Optimization through Iterative Rational Drug Design. J.Med.Chem., 62:467-479, 2019 Cited by PubMed: 30540910DOI: 10.1021/acs.jmedchem.8b01561 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.08 Å) |
Structure validation
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