Author results

6CD2
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CRYSTAL STRUCTURE OF THE PAPC USHER BOUND TO THE CHAPERONE-ADHESIN PAPD-PAPG
Descriptor:Chaperone protein PapD, PapGII adhesin protein, Outer membrane usher protein PapC
Authors:Omattage, N.S., Deng, Z., Yuan, P., Hultgren, S.J.
Deposit date:2018-02-07
Release date:2018-10-03
Last modified:2018-12-12
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structural basis for usher activation and intramolecular subunit transfer in P pilus biogenesis in Escherichia coli.
Nat Microbiol, 3, 2018
6AOW
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CRYSTAL STRUCTURE OF LECTIN DOMAIN OF F9 PILUS ADHESIN FMLH FROM E. COLI UTI89
Descriptor:F9 pilus adhesin FmlH, SULFATE ION
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2017-08-16
Release date:2018-02-28
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of lectin domain of F9 pilus adhesin FmlH from E. coli UTI89
To Be Published
6AOX
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F9 PILUS ADHESIN FMLH LECTIN DOMAIN FROM E. COLI UTI89 CO-CRYSTALLIZED WITH TF ANTIGEN
Descriptor:Fml fimbrial adhesin FmlD, 2-(acetylamino)-2-deoxy-3-O-beta-D-galactopyranosyl-alpha-D-galactopyranose
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2017-08-16
Release date:2018-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of lectin domain of F9 pilus adhesin FmlH from E. coli UTI89
To Be Published
6AOY
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F9 PILUS ADHESIN FMLH LECTIN DOMAIN FROM E. COLI UTI89 CO-CRYSTALLIZED WITH O-NITROPHENYL BETA-GALACTOSIDE (ONPG)
Descriptor:Fml fimbrial adhesin FmlD, SULFATE ION, 1-O-[O-NITROPHENYL]-BETA-D-GALACTOPYRANOSE
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2017-08-16
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of lectin domain of F9 pilus adhesin FmlH from E. coli UTI89 bound to o-nitrophenyl beta-galactoside (ONPG)
To Be Published
6ARM
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F9 PILUS ADHESIN FMLH LECTIN DOMAIN FROM E. COLI UTI89 CO-CRYSTALLIZED WITH O-NITROPHENYL BETA-GALACTOSIDE (ONPG)
Descriptor:F9 pilus adhesin FmlH, 1-O-[O-NITROPHENYL]-BETA-D-GALACTOPYRANOSE, SULFATE ION
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2017-08-22
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:F9 pilus adhesin FmlH lectin domain from E. coli UTI89 co-crystallized with o-nitrophenyl beta-galactoside (ONPG)
To Be Published
6ARN
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F9 PILUS ADHESIN FMLH LECTIN DOMAIN FROM E. COLI UTI89 CO-CRYSTALLIZED WITH O-METHOXYPHENYL BETA-GALACTOSIDE (OMPG)
Descriptor:Putative Fml fimbrial adhesin FmlD, 2-methoxyphenyl beta-D-galactopyranoside, SULFATE ION
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2017-08-22
Release date:2018-02-28
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:F9 pilus adhesin FmlH lectin domain from E. coli UTI89 co-crystallized with o-methoxyphenyl beta-galactoside (OMPG)
To Be Published
6ARO
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F9 PILUS ADHESIN FMLH LECTIN DOMAIN FROM E. COLI UTI89 CO-CRYSTALLIZED WITH 8-HYDROXYQUINOLINE BETA-GALACTOSIDE
Descriptor:F9 pilus adhesin FmlH, quinolin-8-yl beta-D-galactopyranoside, SULFATE ION
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2017-08-23
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:F9 pilus adhesin FmlH lectin domain from E. coli UTI89 co-crystallized with 8-hydroxyquinoline beta-galactoside
To Be Published
6AS8
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F9 PILUS ADHESIN FMLH LECTIN DOMAIN FROM E. COLI UTI89 CO-CRYSTALLIZED WITH ORTHO-BIPHENYL-2'-CARBOXYL N-ACETYL-BETA-GALACTOSAMINOSIDE
Descriptor:Fml fimbrial adhesin FmlD, 2'-{[2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl]oxy}[1,1'-biphenyl]-3-carboxylic acid
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2017-08-23
Release date:2018-02-28
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:F9 pilus adhesin FmlH lectin domain from E. coli UTI89 co-crystallized with ortho-biphenyl-2'-carboxyl N-acetyl-beta-galactosaminoside
To Be Published
6C53
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CRYO-EM STRUCTURE OF THE TYPE 1 PILUS ROD
Descriptor:Type-1 fimbrial protein, A chain
Authors:Zheng, W., Wang, F., Luna-Rico, A., Francetic, O., Hultgren, S.J., Egelman, E.H.
Deposit date:2018-01-13
Release date:2018-01-31
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions.
Elife, 7, 2018
5NWP
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CRYSTAL STRUCTURE OF THE LECTIN DOMAIN FROM THE F17-LIKE ADHESIN, UCLD
Descriptor:Adhesin, SULFATE ION
Authors:Ruer, S., Remaut, H.
Deposit date:2017-05-08
Release date:2017-06-21
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.
Nature, 546, 2017
5VQ5
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CRYSTAL STRUCTURE OF THE LECTIN DOMAIN FROM THE F17-LIKE ADHESIN, UCLD
Descriptor:Adhesin, IODIDE ION
Authors:Klein, R.D., Spaulding, C.N., Dodson, K.W., Pinkner, J.S., Hultgren, S.J., Fremont, D.
Deposit date:2017-05-08
Release date:2017-05-24
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.
Nature, 546, 2017
5JQI
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CRYSTAL STRUCTURE OF FIMH A62S FROM E. COLI UTI89 BOUND TO FIMG N-TERMINAL EXTENSION
Descriptor:FimG N-terminal extension, Type 1 fimbiral adhesin FimH, GLYCEROL
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2016-05-05
Release date:2017-02-22
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.962 Å)
Cite:Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions.
Sci Adv, 3, 2017
5JR4
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CRYSTAL STRUCTURE OF FIMH A27V/V163A FROM E. COLI UTI89 BOUND TO FIMG N-TERMINAL EXTENSION
Descriptor:Type 1 fimbiral adhesin FimH, FimG N-terminal extension, GLYCEROL, ...
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2016-05-05
Release date:2017-02-22
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.596 Å)
Cite:Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions.
Sci Adv, 3, 2017
5F3F
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CRYSTAL STRUCTURE OF PARA-BIPHENYL-2-METHYL-3'-METHYL AMIDE MANNOSIDE BOUND TO FIMH LECTIN DOMAIN
Descriptor:Protein FimH, 3-[4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-methyl-phenyl]-~{N}-methyl-benzamide
Authors:Klein, R.D., Hultgren, S.J.
Deposit date:2015-12-02
Release date:2016-12-07
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Antibiotic-sparing therapy against gram-negative UPEC bacteria: Potent anti-virulence activity of FimH C-mannoside antagonists
To Be Published
5LNE
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E. COLI F9 PILUS ADHESIN FMLH BOUND TO THE THOMSEN-FRIEDENREICH (TF) ANTIGEN
Descriptor:Putative Fml fimbrial adhesin FmlD, N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE, BETA-D-GALACTOSE, ...
Authors:Ruer, S., Conover, M.S., Kalas, V., Taganna, J., De Greve, H., Pinkner, J.S., Dodson, K.W., Hultgren, S.J., Remaut, H.
Deposit date:2016-08-04
Release date:2016-10-05
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection.
Cell Host Microbe, 20, 2016
5LNG
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LECTIN DOMAIN OF E. COLI F9 PILUS ADHESIN FMLH
Descriptor:Putative Fml fimbrial adhesin FmlD, SULFATE ION
Authors:Ruer, S., Conover, M.S., Kalas, V., Taganna, J., De Greve, H., Pinkner, J.S., Dodson, K.W., Hultgren, S.J., Remaut, H.
Deposit date:2016-08-04
Release date:2016-10-05
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection.
Cell Host Microbe, 20, 2016
2NA4
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CURLI SECRETION SPECIFICITY FACTOR CSGE W48A/F79A MUTANT
Descriptor:Curli production assembly/transport component CsgE
Authors:Shu, Q., Krezel, A.M., Frieden, C.
Deposit date:2015-12-21
Release date:2016-06-15
Last modified:2016-08-31
Method:SOLUTION NMR
Cite:Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation.
Proc.Natl.Acad.Sci.USA, 113, 2016
5F2F
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CRYSTAL STRUCTURE OF PARA-BIPHENYL-2-METHYL-3', 5' DI-METHYL AMIDE MANNOSIDE BOUND TO FIMH LECTIN DOMAIN
Descriptor:Protein FimH, 5-[4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-methyl-phenyl]-~{N}1,~{N}3-dimethyl-benzene-1,3-dicarboxamide, GLYCEROL
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2015-12-01
Release date:2016-05-04
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.665 Å)
Cite:Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI.
Chemmedchem, 11, 2016
5FLU
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STRUCTURE OF A CHAPERONE-USHER PILUS REVEALS THE MOLECULAR BASIS OF ROD UNCOILIN
Descriptor:PAP FIMBRIAL MAJOR PILIN PROTEIN
Authors:Hospenthal, M.K., Redzej, A., Dodson, K., Ukleja, M., Frenz, B., Hultgren, S.J., DiMaio, F., Egelman, E.H., Waksman, G.
Deposit date:2015-10-28
Release date:2016-01-13
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling.
Cell(Cambridge,Mass.), 164, 2016
4UV2
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STRUCTURE OF THE CURLI TRANSPORT LIPOPROTEIN CSGG IN A NON-LIPIDATED, PRE-PORE CONFORMATION
Descriptor:CURLI PRODUCTION TRANSPORT COMPONENT CSGG
Authors:Goyal, P., Krasteva, P.V., Gerven, N.V., Gubellini, F., Broeck, I.V.D., Troupiotis-Tsailaki, A., Jonckheere, W., Pehau-Arnaudet, G., Pinkner, J.S., Chapman, M.R., Hultgren, S.J., Howorka, S., Fronzes, R., Remaut, H.
Deposit date:2014-08-04
Release date:2014-09-24
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and Mechanistic Insights Into the Bacterial Amyloid Secretion Channel Csgg.
Nature, 516, 2014
4UV3
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STRUCTURE OF THE CURLI TRANSPORT LIPOPROTEIN CSGG IN ITS MEMBRANE- BOUND CONFORMATION
Descriptor:CURLI PRODUCTION ASSEMBLY/TRANSPORT COMPONENT CSGG
Authors:Goyal, P., Krasteva, P.V., Gerven, N.V., Gubellini, F., Broeck, I.V.D., Troupiotis-Tsailaki, A., Jonckheere, W., Pehau-Arnaudet, G., Pinkner, J.S., Chapman, M.R., Hultgren, S.J., Howorka, S., Fronzes, R., Remaut, H.
Deposit date:2014-08-04
Release date:2014-09-24
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (3.59 Å)
Cite:Structural and Mechanistic Insights Into the Bacterial Amyloid Secretion Channel Csgg.
Nature, 516, 2014
4J3O
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CRYSTAL STRUCTURE OF THE FIMD USHER TRAVERSED BY THE PILUS TIP COMPLEX ASSEMBLY COMPOSED OF FIMC:FIMF:FIMG:FIMH
Descriptor:Protein FimG, Protein FimH, Chaperone protein FimC, ...
Authors:Geibel, S., Waksman, G.
Deposit date:2013-02-06
Release date:2013-04-10
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural and energetic basis of folded-protein transport by the FimD usher.
Nature, 496, 2013
3OHN
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CRYSTAL STRUCTURE OF THE FIMD TRANSLOCATION DOMAIN
Descriptor:Outer membrane usher protein FimD
Authors:Wang, T., Li, H.
Deposit date:2010-08-17
Release date:2011-06-01
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (3.011 Å)
Cite:Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate.
Nature, 474, 2011
3RFZ
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CRYSTAL STRUCTURE OF THE FIMD USHER BOUND TO ITS COGNATE FIMC:FIMH SUBSTRATE
Descriptor:Type 1 fimbrial adhesin, Outer membrane usher protein, type 1 fimbrial synthesis, ...
Authors:Phan, G., Remaut, H., Lebedev, A., Geibel, S., Waksman, G.
Deposit date:2011-04-07
Release date:2011-06-01
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate.
Nature, 474, 2011
3ME0
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STRUCTURE OF THE E. COLI CHAPERONE PAPD IN COMPLEX WITH THE PILIN DOMAIN OF THE PAPGII ADHESIN
Descriptor:Chaperone protein papD, PapG protein
Authors:Ford, B.A., Elam, J.S., Dodson, K.W., Pinkner, J.S., Hultgren, S.J.
Deposit date:2010-03-31
Release date:2011-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structure of the E. Coli Chaperone PapD in Complex with the Pilin Domain of the PapGII Adhesin
To be Published
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