Author results

2JQC
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A L-AMINO ACID MUTANT OF A D-AMINO ACID CONTAINING CONOPEPTIDE
Descriptor:L-mr12
Authors:Huang, F., Du, W., Han, Y., Wang, C., Chi, C.
Deposit date:2007-05-31
Release date:2008-04-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Purification and structural characterization of a d-amino acid-containing conopeptide, conomarphin, from Conus marmoreus
Febs J., 275, 2008
2YYF
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PURIFICATION AND STRUCTURAL CHARACTERIZATION OF A D-AMINO ACID CONTAINING CONOPEPTIDE, MARMOPHINE, FROM CONUS MARMOREUS
Descriptor:M-conotoxin mr12
Authors:Huang, F., Du, W., Han, Y., Wang, C.
Deposit date:2007-04-29
Release date:2008-04-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Purification and structural characterization of a D-amino acid-containing conopeptide, conomarphin, from Conus marmoreus.
Febs J., 275, 2008
5DI8
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FC KNOB-HOLE HETERODIMER T366W + T366S/L368A/Y407V
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B.
Deposit date:2015-08-31
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJ0
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FC HETERODIMER DESIGN 11.2 Y349S/K370Y + E357D/S364Q
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-01
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJ2
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FC HETERODIMER DESIGN 7.4 Y407A + T366V/K409V
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-01
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJ6
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FC HETERODIMER DESIGN 6.1 F405W/Y407A + T366M
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-01
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJ8
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FC HETERODIMER DESIGN 7.7 D399M/Y407A + T366V/K409I
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-01
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJA
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FC HETERODIMER DESIGN 9.1 Y407M + T366I
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-01
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJC
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FC HETERODIMER DESIGN 8.1 L368V/Y407A + T366V/K409F
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Secrist, E., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-01
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJD
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FC HETERODIMER DESIGN 5.1 T366V + Y407F
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-02
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJX
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FC HETERODIMER DESIGN 2.9 L368M/K370E + E357A/S364G
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-02
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJY
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FC HETERODIMER DESIGN 20.8 Y349S/T366V/K370Y/K409V + E357D/S364Q/Y407A
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-02
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DJZ
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FC HETERODIMER DESIGN 7.8 D399M/Y407A + T366V/K409V
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-02
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DK0
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FC HETERODIMER DESIGN 20.8.34 Y349S/T366M/K370Y/K409V + E356G/E357D/S364Q/Y407A
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-02
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DK2
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FC HETERODIMER E356K/D399K + K392D/K409D
Descriptor:Ig gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-02
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DVK
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FC DESIGN 7.7 B CHAIN HOMODIMER T366V/K409I
Descriptor:Ig gamma-1 chain C region
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-21
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DVL
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FC DESIGN 20.8.37 A CHAIN HOMODIMER Y349S/T366M/K370Y/K409V
Descriptor:Ig gamma-1 chain C region, Fc-III peptide
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-21
Release date:2016-03-30
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DVM
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FC DESIGN 20.8.37 B CHAIN HOMODIMER E357D/S364R/Y407A
Descriptor:Ig gamma-1 chain C region, Fc-III peptide
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-21
Release date:2016-03-30
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DVN
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FC K392D/K409D HOMODIMER
Descriptor:Ig gamma-1 chain C region, Fc-III peptide
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-21
Release date:2016-03-30
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
5DVO
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FC K392D/K409D HOMODIMER
Descriptor:Ig gamma-1 chain C region, SULFATE ION
Authors:Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.
Deposit date:2015-09-21
Release date:2016-03-30
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24, 2016
1NL9
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POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR COMPOUND 12 USING A LINKED-FRAGMENT STRATEGY
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, 2-{[4-(2-ACETYLAMINO-2-PENTYLCARBAMOYL-ETHYL)-NAPHTHALEN-1-YL]-OXALYL-AMINO}-BENZOIC ACID
Authors:Szczepankiewicz, B.G., Liu, G., Hajduk, P.J., Abad-Zapatero, C., Pei, Z., Xin, Z., Lubben, T., Trevillyan, J.M., Stashko, M.A., Ballaron, S.J., Liang, H., Huang, F., Hutchins, C.W., Fesik, S.W., Jirousek, M.R.
Deposit date:2003-01-06
Release date:2003-04-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy
J.Am.Chem.Soc., 125, 2003
1NNY
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POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR COMPOUND 23 USING A LINKED-FRAGMENT STRATEGY
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, 3-({5-[(N-ACETYL-3-{4-[(CARBOXYCARBONYL)(2-CARBOXYPHENYL)AMINO]-1-NAPHTHYL}-L-ALANYL)AMINO]PENTYL}OXY)-2-NAPHTHOIC ACID
Authors:Szczepankiewicz, B.G., Liu, G., Hajduk, P.J., Abad-Zapatero, C., Pei, Z., Xin, Z., Lubben, T., Trevillyan, J.M., Stashko, M.A., Ballaron, S.J., Liang, H., Huang, F., Hutchins, C.W., Fesik, S.W., Jirousek, M.R.
Deposit date:2003-01-14
Release date:2003-04-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy
J.Am.Chem.Soc., 125, 2003
1NO6
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POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR COMPOUND 5 USING A LINKED-FRAGMENT STRATEGY
Descriptor:Protein-tyrosine phosphatase, non-receptor type 1, 2-[(CARBOXYCARBONYL)(1-NAPHTHYL)AMINO]BENZOIC ACID
Authors:Szczepankiewicz, B.G., Liu, G., Hajduk, P.J., Abad-Zapatero, C., Pei, Z., Xin, Z., Lubben, T., Trevillyan, J.M., Stashko, M.A., Ballaron, S.J., Liang, H., Huang, F., Hutchins, C.W., Fesik, S.W., Jirousek, M.R.
Deposit date:2003-01-15
Release date:2003-04-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy
J.Am.Chem.Soc., 125, 2003
1RQP
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CRYSTAL STRUCTURE AND MECHANISM OF A BACTERIAL FLUORINATING ENZYME
Descriptor:5'-fluoro-5'-deoxyadenosine synthase, S-ADENOSYLMETHIONINE
Authors:Dong, C., Huang, F., Deng, H., Schaffrath, C., Spencer, J.B., O'Hagan, D., Naismith, J.H.
Deposit date:2003-12-06
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure and mechanism of a bacterial fluorinating enzyme
Nature, 427, 2004
1RQR
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CRYSTAL STRUCTURE AND MECHANISM OF A BACTERIAL FLUORINATING ENZYME, PRODUCT COMPLEX
Descriptor:5'-fluoro-5'-deoxyadenosine synthase, 5'-FLUORO-5'-DEOXYADENOSINE, METHIONINE
Authors:Dong, C., Huang, F., Deng, H., Schaffrath, C., Spencer, J.B., O'Hagan, D., Naismith, J.H.
Deposit date:2003-12-07
Release date:2004-03-02
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Crystal structure and mechanism of a bacterial fluorinating enzyme
Nature, 427, 2004
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