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2QGH
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CRYSTAL STRUCTURE OF DIAMINOPIMELATE DECARBOXYLASE FROM HELICOBACTER PYLORI COMPLEXED WITH L-LYSINE
Descriptor:Diaminopimelate decarboxylase, PYRIDOXAL-5'-PHOSPHATE, LYSINE, ...
Authors:Hu, T., Wu, D., Jiang, H., Shen, X.
Deposit date:2007-06-28
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of diaminopimelate decarboxylase from Helicobacter pylori complexed with L-lysine
TO BE PUBLISHED
3C5Q
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CRYSTAL STRUCTURE OF DIAMINOPIMELATE DECARBOXYLASE (I148L MUTANT) FROM HELICOBACTER PYLORI COMPLEXED WITH L-LYSINE
Descriptor:Diaminopimelate decarboxylase, PYRIDOXAL-5'-PHOSPHATE, LYSINE, ...
Authors:Hu, T., Wu, D., Jiang, H., Shen, X.
Deposit date:2008-02-01
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of diaminopimelate decarboxylase from Helicobacter pylori
To be Published
3F9E
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CRYSTAL STRUCTURE OF THE S139A MUTANT OF SARS-CORONOVIRUS 3C-LIKE PROTEASE
Descriptor:3C-like proteinase
Authors:Hu, T., Li, L., Jiang, H., Shen, X.
Deposit date:2008-11-13
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure.
Virology, 388, 2009
3F9F
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CRYSTAL STRUCTURE OF THE F140A MUTANT OF SARS-CORONOVIRUS 3C-LIKE PROTEASE AT PH 6.0
Descriptor:3C-like proteinase
Authors:Hu, T., Li, L., Jiang, H., Shen, X.
Deposit date:2008-11-13
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure.
Virology, 388, 2009
3F9G
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CRYSTAL STRUCTURE OF THE F140A MUTANT OF SARS-CORONOVIRUS 3C-LIKE PROTEASE AT PH 6.5
Descriptor:3C-like proteinase
Authors:Hu, T., Li, L., Jiang, H., Shen, X.
Deposit date:2008-11-13
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure.
Virology, 388, 2009
3F9H
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CRYSTAL STRUCTURE OF THE F140A MUTANT OF SARS-CORONOVIRUS 3C-LIKE PROTEASE AT PH 7.6
Descriptor:3C-like proteinase
Authors:Hu, T., Li, L., Jiang, H., Shen, X.
Deposit date:2008-11-13
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure.
Virology, 388, 2009
3FXJ
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CRYSTAL STRUCTURE OF HUMAN PROTEIN PHOSPHATASE 1A (PPM1A) BOUND WITH PHOSPHATE AT 3 MM OF MN2+
Descriptor:Protein phosphatase 1A, MANGANESE (II) ION, PHOSPHATE ION
Authors:Hu, T., Wang, L., Wang, K., Jiang, H., Shen, X.
Deposit date:2009-01-21
Release date:2010-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the Mn2+-dependent activation of human PPM1A
To be published
3FXK
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CRYSTAL STRUCTURE OF HUMAN PROTEIN PHOSPHATASE 1A (PPM1A) BOUND WITH PHOSPHATE AT 10 MM OF MN2+
Descriptor:Protein phosphatase 1A, MANGANESE (II) ION, PHOSPHATE ION
Authors:Hu, T., Wang, L., Wang, K., Jiang, H., Shen, X.
Deposit date:2009-01-21
Release date:2010-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the Mn2+-dependent activation of human PPM1A
To be published
3FXL
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CRYSTAL STRUCTURE OF HUMAN PROTEIN PHOSPHATASE 1A (PPM1A) BOUND WITH CITRATE AT 1 MM OF MN2+
Descriptor:Protein phosphatase 1A, MANGANESE (II) ION, PHOSPHATE ION, ...
Authors:Hu, T., Wang, L., Wang, K., Jiang, H., Shen, X.
Deposit date:2009-01-21
Release date:2010-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the Mn2+-dependent activation of human PPM1A
To be published
3FXM
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CRYSTAL STRUCTURE OF HUMAN PROTEIN PHOSPHATASE 1A (PPM1A) BOUND WITH CITRATE AT 10 MM OF MN2+
Descriptor:Protein phosphatase 1A, MANGANESE (II) ION, PHOSPHATE ION, ...
Authors:Hu, T., Wang, L., Wang, K., Jiang, H., Shen, X.
Deposit date:2009-01-21
Release date:2010-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the Mn2+-dependent activation of human PPM1A
To be published
3FXO
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CRYSTAL STRUCTURE OF HUMAN PROTEIN PHOSPHATASE 1A (PPM1A) BOUND WITH PHOSPHATE AT 1 MM OF MN2+
Descriptor:Protein phosphatase 1A, MANGANESE (II) ION, PHOSPHATE ION
Authors:Hu, T., Wang, L., Wang, K., Jiang, H., Shen, X.
Deposit date:2009-01-21
Release date:2010-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the Mn2+-dependent activation of human PPM1A
To be published
4ZIA
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CRYSTAL STRUCTURE OF STAT3 N-TERMINAL DOMAIN
Descriptor:Signal transducer and activator of transcription 3, NICKEL (II) ION, FORMIC ACID, ...
Authors:Hu, T., Chopra, R.
Deposit date:2015-04-28
Release date:2015-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional Activity.
Mol.Cell.Biol., 35, 2015
5CZV
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CRYSTAL STRUCTURE OF NOTCH3 NRR IN COMPLEX WITH 20350 FAB
Descriptor:Neurogenic locus notch homolog protein 3, Fab 20350 heavy chain, Fab 20350 light chain, ...
Authors:Hu, T., Fryer, C., Chopra, R., Clark, K.
Deposit date:2015-08-01
Release date:2016-06-01
Last modified:2016-12-07
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies.
Oncogene, 35, 2016
5CZX
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CRYSTAL STRUCTURE OF NOTCH3 NRR IN COMPLEX WITH 20358 FAB
Descriptor:Neurogenic locus notch homolog protein 3, 20358 Fab heavy chain, 20358 Fab light chain, ...
Authors:Hu, T., Fryer, C., Chopra, R., Clark, K.
Deposit date:2015-08-01
Release date:2016-06-01
Last modified:2016-12-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies.
Oncogene, 35, 2016
6EG2
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CRYSTAL STRUCTURE OF HUMAN BRM IN COMPLEX WITH COMPOUND 16
Descriptor:Maltose/maltodextrin-binding periplasmic protein,Probable global transcription activator SNF2L2, N-(5-amino-2-chloropyridin-4-yl)-N'-(4-bromo-3-{[3-(hydroxymethyl)phenyl]ethynyl}-1,2-thiazol-5-yl)urea, ISOPROPYL ALCOHOL
Authors:Zhu, X., Kulathila, R., Hu, T., Xie, X.
Deposit date:2018-08-17
Release date:2018-10-31
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.
J. Med. Chem., 61, 2018
6EG3
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CRYSTAL STRUCTURE OF HUMAN BRM IN COMPLEX WITH COMPOUND 15
Descriptor:Maltose/maltodextrin-binding periplasmic protein,Probable global transcription activator SNF2L2, 3-[(4-{[(2-chloropyridin-4-yl)carbamoyl]amino}pyridin-2-yl)ethynyl]benzoic acid, ETHANOL
Authors:Zhu, X., Kulathila, R., Hu, T., Xie, X.
Deposit date:2018-08-17
Release date:2018-10-31
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.
J. Med. Chem., 61, 2018
5VEB
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CRYSTAL STRUCTURE OF A FAB BINDING TO EXTRACELLULAR DOMAIN 5 OF CADHERIN-6
Descriptor:anti-CDH6 Fab heavy chain, anti-CDH6 Fab light chain, Cadherin-6, ...
Authors:Zhu, X., Bialucha, C.U., London, A., Clark, K., Hu, T.
Deposit date:2017-04-04
Release date:2017-06-07
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers.
Cancer Discov, 7, 2017
2PWX
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CRYSTAL STRUCTURE OF G11A MUTANT OF SARS-COV 3C-LIKE PROTEASE
Descriptor:3C-like proteinase
Authors:Chen, S., Hu, T., Jiang, H., Shen, X.
Deposit date:2007-05-14
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease: crystal structure with molecular dynamics simulations.
J.Biol.Chem., 283, 2008
2RJG
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CRYSTAL STRUCTURE OF BIOSYNTHETIC ALAINE RACEMASE FROM ESCHERICHIA COLI
Descriptor:Alanine racemase, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Wu, D., Hu, T., Zhang, L., Jiang, H., Shen, X.
Deposit date:2007-10-15
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis
Protein Sci., 17, 2008
2RJH
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CRYSTAL STRUCTURE OF BIOSYNTHETIC ALAINE RACEMASE IN D-CYCLOSERINE-BOUND FORM FROM ESCHERICHIA COLI
Descriptor:Alanine racemase, SULFATE ION, D-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-N,O-CYCLOSERYLAMIDE
Authors:Wu, D., Hu, T., Zhang, L., Jiang, H., Shen, X.
Deposit date:2007-10-15
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis
Protein Sci., 17, 2008
3B8T
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI ALAINE RACEMASE MUTANT P219A
Descriptor:Alanine racemase, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Wu, D., Hu, T., Zhang, L., Jiang, H., Shen, X.
Deposit date:2007-11-02
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis
Protein Sci., 17, 2008
3B8U
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI ALAINE RACEMASE MUTANT E221A
Descriptor:Alanine racemase, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Wu, D., Hu, T., Zhang, L., Jiang, H., Shen, X.
Deposit date:2007-11-02
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis
Protein Sci., 17, 2008
3B8V
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI ALAINE RACEMASE MUTANT E221K
Descriptor:Alanine racemase, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Wu, D., Hu, T., Zhang, L., Jiang, H., Shen, X.
Deposit date:2007-11-02
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis
Protein Sci., 17, 2008
3B8W
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI ALAINE RACEMASE MUTANT E221P
Descriptor:Alanine racemase, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Wu, D., Hu, T., Zhang, L., Jiang, H., Shen, X.
Deposit date:2007-11-02
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis
Protein Sci., 17, 2008
3CVA
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HUMAN BCL-XL CONTAINING A TRP TO ALA MUTATION AT POSITION 137
Descriptor:Apoptosis regulator Bcl-X
Authors:Feng, Y., Zhang, L., Hu, T., Shen, X., Chen, K., Jiang, H., Liu, D.
Deposit date:2008-04-18
Release date:2009-03-24
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A conserved hydrophobic core at Bcl-x(L) mediates its structural stability and binding affinity with BH3-domain peptide of pro-apoptotic protein
Arch.Biochem.Biophys., 484, 2009
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