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3PDS
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IRREVERSIBLE AGONIST-BETA2 ADRENOCEPTOR COMPLEX
Descriptor:Fusion protein Beta-2 adrenergic receptor/Lysozyme, 8-hydroxy-5-[(1R)-1-hydroxy-2-({2-[3-methoxy-4-(3-sulfanylpropoxy)phenyl]ethyl}amino)ethyl]quinolin-2(1H)-one, CHOLESTEROL, ...
Authors:Rosenbaum, D.M., Zhang, C., Lyons, J.A., Holl, R., Aragao, D., Arlow, D.H., Rasmussen, S.G.F., Choi, H.-J., DeVree, B.T., Sunahara, R.K., Chae, P.S., Gellman, S.H., Dror, R.O., Shaw, D.E., Weis, W.I., Caffrey, M., Gmeiner, P., Kobilka, B.K.
Deposit date:2010-10-24
Release date:2011-01-12
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure and function of an irreversible agonist-beta(2) adrenoceptor complex
Nature, 469, 2011
6HQY
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CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 COMPLEXED WITH PCI-34051
Descriptor:Histone deacetylase, ZINC ION, POTASSIUM ION, ...
Authors:Marek, M., Shaik, T.B., Romier, C.
Deposit date:2018-09-25
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018
6HRQ
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CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 COMPLEXED WITH NCC-149
Descriptor:Histone deacetylase, ZINC ION, POTASSIUM ION, ...
Authors:Shaik, T.B., Marek, M., Romier, C.
Deposit date:2018-09-28
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.845 Å)
Cite:Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018
6HSF
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CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 MUTANT H292M COMPLEXED WITH PCI-34051
Descriptor:Histone deacetylase, ZINC ION, POTASSIUM ION, ...
Authors:Shaik, T.B., Marek, M., Romier, C.
Deposit date:2018-10-01
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018
6HSG
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CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 H292M MUTANT COMPLEXED WITH NCC-149
Descriptor:Histone deacetylase, ZINC ION, POTASSIUM ION, ...
Authors:Shaik, T.B., Marek, M., Romier, C.
Deposit date:2018-10-01
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.846 Å)
Cite:Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018
6HSH
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CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 COMPLEXED WITH QUISINOSTAT
Descriptor:Histone deacetylase, ZINC ION, POTASSIUM ION, ...
Authors:Shaik, T.B., Marek, M., Romier, C.
Deposit date:2018-10-01
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.545 Å)
Cite:Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018
6HSK
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CRYSTAL STRUCTURE OF A HUMAN HDAC8 L6 LOOP MUTANT COMPLEXED WITH QUISINOSTAT
Descriptor:Histone deacetylase 8, ZINC ION, POTASSIUM ION, ...
Authors:Marek, M., Shaik, T.B., Ramos-Morales, E., Romier, C.
Deposit date:2018-10-01
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.096 Å)
Cite:Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018
6HSZ
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CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 COMPLEXED WITH A BENZOHYDROXAMATE INHIBITOR 2
Descriptor:Histone deacetylase, ZINC ION, POTASSIUM ION, ...
Authors:Marek, M., Shaik, T.B., Romier, C.
Deposit date:2018-10-02
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.374 Å)
Cite:Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018
6HT8
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CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 COMPLEXED WITH A BENZOHYDROXAMATE INHIBITOR 3
Descriptor:Histone deacetylase, ZINC ION, POTASSIUM ION, ...
Authors:Marek, M., Shaik, T.B., Romier, C.
Deposit date:2018-10-03
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018
6HTG
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CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 COMPLEXED WITH A BENZOHYDROXAMATE INHIBITOR 4
Descriptor:Histone deacetylase, ZINC ION, POTASSIUM ION, ...
Authors:Shaik, T.B., Marek, M., Romier, C.
Deposit date:2018-10-04
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.939 Å)
Cite:Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018
6HTH
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CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 COMPLEXED WITH A BENZOHYDROXAMATE INHIBITOR 5
Descriptor:Histone deacetylase, ZINC ION, POTASSIUM ION, ...
Authors:Shaik, T.B., Marek, M., Romier, C.
Deposit date:2018-10-04
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018
6HTI
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CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 COMPLEXED WITH A BENZOHYDROXAMATE INHIBITOR 6
Descriptor:Histone deacetylase, ZINC ION, POTASSIUM ION, ...
Authors:Shaik, T.B., Marek, M., Romier, C.
Deposit date:2018-10-04
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.693 Å)
Cite:Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018
6HTT
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CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 COMPLEXED WITH A BENZOHYDROXAMATE INHIBITOR 7
Descriptor:Histone deacetylase, ZINC ION, POTASSIUM ION, ...
Authors:Shaik, T.B., Marek, M., Romier, C.
Deposit date:2018-10-04
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.748 Å)
Cite:Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018
6HTZ
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CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 COMPLEXED WITH A BENZOHYDROXAMATE INHIBITOR 8
Descriptor:Histone deacetylase, ZINC ION, POTASSIUM ION, ...
Authors:Shaik, T.B., Marek, M., Romier, C.
Deposit date:2018-10-05
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.841 Å)
Cite:Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018
6HU0
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CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 COMPLEXED WITH A BENZOHYDROXAMATE INHIBITOR 9
Descriptor:Histone deacetylase, ZINC ION, POTASSIUM ION, ...
Authors:Shaik, T.B., Marek, M., Romier, C.
Deposit date:2018-10-05
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.746 Å)
Cite:Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018
6HU1
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CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 COMPLEXED WITH A BENZOHYDROXAMATE INHIBITOR 10
Descriptor:Histone deacetylase, ZINC ION, POTASSIUM ION, ...
Authors:Shaik, T.B., Marek, M., Romier, C.
Deposit date:2018-10-05
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.996 Å)
Cite:Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018
6HU2
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CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 COMPLEXED WITH A BENZOHYDROXAMATE INHIBITOR 11
Descriptor:Histone deacetylase, ZINC ION, POTASSIUM ION, ...
Authors:Shaik, T.B., Marek, M., Romier, C.
Deposit date:2018-10-05
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.986 Å)
Cite:Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018
6HU3
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CRYSTAL STRUCTURE OF SCHISTOSOMA MANSONI HDAC8 COMPLEXED WITH A TRIAZOLE HYDROXAMATE INHIBITOR
Descriptor:Histone deacetylase, ZINC ION, POTASSIUM ION, ...
Authors:Shaik, T.B., Marek, M., Romier, C.
Deposit date:2018-10-05
Release date:2018-10-31
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.655 Å)
Cite:Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018