6HQY
Crystal structure of Schistosoma mansoni HDAC8 complexed with PCI-34051
Summary for 6HQY
Entry DOI | 10.2210/pdb6hqy/pdb |
Descriptor | Histone deacetylase, ZINC ION, POTASSIUM ION, ... (6 entities in total) |
Functional Keywords | epigenetics, histone deacetylase, hdac8, selective inhibitor, pathogen, hydrolase |
Biological source | Schistosoma mansoni (Blood fluke) |
Total number of polymer chains | 4 |
Total formula weight | 204644.38 |
Authors | Marek, M.,Shaik, T.B.,Romier, C. (deposition date: 2018-09-25, release date: 2018-10-31, Last modification date: 2024-01-24) |
Primary citation | Marek, M.,Shaik, T.B.,Heimburg, T.,Chakrabarti, A.,Lancelot, J.,Ramos-Morales, E.,Da Veiga, C.,Kalinin, D.,Melesina, J.,Robaa, D.,Schmidtkunz, K.,Suzuki, T.,Holl, R.,Ennifar, E.,Pierce, R.J.,Jung, M.,Sippl, W.,Romier, C. Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61:10000-10016, 2018 Cited by PubMed: 30347148DOI: 10.1021/acs.jmedchem.8b01087 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.501 Å) |
Structure validation
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