Author results

2MS7
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HIGH-RESOLUTION SOLID-STATE NMR STRUCTURE OF THE HELICAL SIGNAL TRANSDUCTION FILAMENT MAVS CARD
Descriptor:Mitochondrial antiviral-signaling protein
Authors:He, L., Bardiaux, B., Spehr, J., Luehrs, T., Ritter, C.
Deposit date:2014-07-25
Release date:2015-09-02
Last modified:2016-02-03
Method:SOLID-STATE NMR
Cite:Structure determination of helical filaments by solid-state NMR spectroscopy.
Proc.Natl.Acad.Sci.USA, 113, 2016
3DOY
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CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH COMPOUND 3I
Descriptor:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ...
Authors:Zhang, L., He, L., Liu, X., Liu, H., Shen, X., Jiang, H.
Deposit date:2008-07-07
Release date:2009-05-05
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J.Med.Chem., 52, 2009
3DOZ
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CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH COMPOUND 3K
Descriptor:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ...
Authors:Zhang, L., He, L., Liu, X., Liu, H., Shen, X., Jiang, H.
Deposit date:2008-07-07
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J.Med.Chem., 52, 2009
3DP0
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CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH COMPOUND 3M
Descriptor:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ...
Authors:Zhang, L., He, L., Liu, X., Liu, H., Shen, X., Jiang, H.
Deposit date:2008-07-07
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J.Med.Chem., 52, 2009
3DP1
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CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH COMPOUND 3N
Descriptor:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ...
Authors:Zhang, L., He, L., Liu, X., Liu, H., Shen, X., Jiang, H.
Deposit date:2008-07-07
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J.Med.Chem., 52, 2009
3DP2
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CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH COMPOUND 3J
Descriptor:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ...
Authors:Zhang, L., He, L., Liu, X., Liu, H., Shen, X., Jiang, H.
Deposit date:2008-07-07
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J.Med.Chem., 52, 2009
3DP3
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CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH COMPOUND 3Q
Descriptor:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ...
Authors:Zhang, L., He, L., Liu, X., Liu, H., Shen, X., Jiang, H.
Deposit date:2008-07-07
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J.Med.Chem., 52, 2009
2MS8
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SOLUTION NMR STRUCTURE OF MAVS CARD
Descriptor:Mitochondrial antiviral-signaling protein
Authors:Spehr, J., He, L., Luehrs, T., Ritter, C.
Deposit date:2014-07-25
Release date:2015-09-02
Last modified:2016-02-03
Method:SOLUTION NMR
Cite:Structure determination of helical filaments by solid-state NMR spectroscopy.
Proc.Natl.Acad.Sci.USA, 113, 2016
5YEI
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MECHANISTIC INSIGHT INTO THE REGULATION OF PSEUDOMONAS AERUGINOSA ASPARTATE KINASE
Descriptor:Aspartokinase, THREONINE, LYSINE, ...
Authors:Li, C., Yang, M., Liu, L., Peng, C., Li, T., He, L., Song, Y., Zhu, Y., Bao, R.
Deposit date:2017-09-17
Release date:2018-08-29
Last modified:2019-09-11
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Mechanistic insights into the allosteric regulation of Pseudomonas aeruginosa aspartate kinase.
Biochem.J., 475, 2018
5YQZ
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STRUCTURE OF THE GLUCAGON RECEPTOR IN COMPLEX WITH A GLUCAGON ANALOGUE
Descriptor:Glucagon receptor,Endolysin,Glucagon receptor, Glucagon analogue, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Zhang, H., Qiao, A., Yang, L., VAN EPS, N., Frederiksen, K., Yang, D., Dai, A., Cai, X., Zhang, H., Yi, C., Can, C., He, L., Yang, H., Lau, J., Ernst, O., Hanson, M., Stevens, R., Wang, M., Seedtz-Runge, S., Jiang, H., Zhao, Q., Wu, B.
Deposit date:2017-11-08
Release date:2018-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the glucagon receptor in complex with a glucagon analogue.
Nature, 553, 2018
1QES
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TANDEM GU MISMATCHES IN RNA, NMR, 30 STRUCTURES
Descriptor:RNA (5'-R(*GP*GP*AP*GP*UP*UP*CP*C)-3')
Authors:Mcdowell, J.A., He, L., Chen, X., Turner, D.H.
Deposit date:1997-03-04
Release date:1997-06-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Investigation of the structural basis for thermodynamic stabilities of tandem GU wobble pairs: NMR structures of (rGGAGUUCC)2 and (rGGAUGUCC)2.
Biochemistry, 36, 1997
1QET
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TANDEM GU MISMATCHES IN RNA, NMR, 30 STRUCTURES
Descriptor:RNA (5'-R(*GP*GP*AP*UP*GP*UP*CP*C)-3')
Authors:Mcdowell, J.A., He, L., Chen, X., Turner, D.H.
Deposit date:1997-03-04
Release date:1997-06-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Investigation of the structural basis for thermodynamic stabilities of tandem GU wobble pairs: NMR structures of (rGGAGUUCC)2 and (rGGAUGUCC)2.
Biochemistry, 36, 1997
6GJQ
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HUMAN NBD1 OF CFTR IN COMPLEX WITH NANOBODY T27
Descriptor:Cystic fibrosis transmembrane conductance regulator, Nanobody T27, ADENOSINE-5'-TRIPHOSPHATE
Authors:Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C.
Deposit date:2018-05-16
Release date:2019-06-19
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.
Nat Commun, 10, 2019
6GJS
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HUMAN NBD1 OF CFTR IN COMPLEX WITH NANOBODIES D12 AND T4
Descriptor:Cystic fibrosis transmembrane conductance regulator, Nanobody D12, Nanobody T4, ...
Authors:Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C.
Deposit date:2018-05-16
Release date:2019-06-26
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.
Nat Commun, 10, 2019
6GJU
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HUMAN NBD1 OF CFTR IN COMPLEX WITH NANOBODIES T2A AND T4
Descriptor:Cystic fibrosis transmembrane conductance regulator, Nanobody T4, Nanobody T2a, ...
Authors:Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C.
Deposit date:2018-05-17
Release date:2019-06-26
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.
Nat Commun, 10, 2019
6GK4
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HUMAN NBD1 OF CFTR IN COMPLEX WITH NANOBODIES D12 AND T8
Descriptor:Cystic fibrosis transmembrane conductance regulator, Nanobody D12, Nanobody T8, ...
Authors:Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C.
Deposit date:2018-05-18
Release date:2019-06-19
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.
Nat Commun, 10, 2019
6GKD
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HUMAN NBD1 OF CFTR IN COMPLEX WITH NANOBODIES D12 AND G3A
Descriptor:Cystic fibrosis transmembrane conductance regulator, Nanobody D12, Nanobody G3a, ...
Authors:Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J.R., Govaerts, C.
Deposit date:2018-05-18
Release date:2019-06-19
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.
Nat Commun, 10, 2019
2FET
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SYNTHESIS OF C-D-GLYCOPYRANOSYL-HYDROQUINONES AND-BENZOQUINONES. INHIBITION OF PTP1B. INHIBITION OF AND BINDING TO GLYCOGEN PHOSPHORYLASE IN THE CRYSTAL
Descriptor:Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Chrysina, E.D., Kosmopoulou, M.N., Leonidas, D.D., Oikonomakos, N.G.
Deposit date:2005-12-16
Release date:2006-12-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:In the Search of Glycogen Phosphorylase Inhibitors: Synthesis of C-D-Glycopyranosylbenzo(hydro)quinones Inhibition of and Binding to Glycogen Phosphorylase in the Crystal
Eur.J.Org.Chem., 4, 2007
2FF5
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SYNTHESIS OF C-D-GLYCOPYRANOSYL-HYDROQUINONES AND-BENZOQUINONES. INHIBITION OF PTP1B. INHIBITION OF AND BINDING TO GLYCOGEN PHOSPHORYLASE IN THE CRYSTAL
Descriptor:Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Chrysina, E.D., Kosmopoulou, M.N., Leonidas, D.D., Oikonomakos, N.G.
Deposit date:2005-12-19
Release date:2006-12-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:In the Search of Glycogen Phosphorylase Inhibitors: Synthesis of C-D-Glycopyranosylbenzo(hydro)quinones Inhibition of and Binding to Glycogen Phosphorylase in the Crystal
Eur.J.Org.Chem., 4, 2007
6CE0
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CRYSTAL STRUCTURE OF A HIV-1 CLADE B TIER-3 ISOLATE H078.14 UFO-BG ENV TRIMER IN COMPLEX WITH BROADLY NEUTRALIZING FABS PGT124 AND 35O22 AT 4.6 ANGSTROM
Descriptor:Envelope glycoprotein gp160, 35O22 Heavy chain, 35O22 Light chain, ...
Authors:Kumar, S., Sarkar, A., Wilson, I.A.
Deposit date:2018-02-09
Release date:2018-12-05
Method:X-RAY DIFFRACTION (4.602 Å)
Cite:HIV-1 vaccine design through minimizing envelope metastability.
Sci Adv, 4, 2018
5WYB
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STRUCTURE OF PSEUDOMONAS AERUGINOSA DSPI
Descriptor:Probable enoyl-CoA hydratase/isomerase, (4R)-2-METHYLPENTANE-2,4-DIOL, ACETATE ION
Authors:Liu, L., Peng, C., Li, T., Li, C., He, L., Song, Y., Zhu, Y., Shen, Y., Bao, R.
Deposit date:2017-01-12
Release date:2018-01-17
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural and functional studies on Pseudomonas aeruginosa DspI: implications for its role in DSF biosynthesis.
Sci Rep, 8, 2018
5ZGD
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HNRNPA1 REVERSIBLE AMYLOID CORE GFGGNDNFG (RESIDUES 209-217) DETERMINED BY X-RAY
Descriptor:GLY-PHE-GLY-GLY-ASN-ASP-ASN-PHE-GLY
Authors:Gui, X., Xie, M., Zhao, M., Luo, F., He, J., Li, D., Liu, C.
Deposit date:2018-03-08
Release date:2019-04-03
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly.
Nat Commun, 10, 2019
5ZGL
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HNRNP A1 SEGMENT GGGYGGS (RESIDUES 234-240)
Descriptor:7-mer peptide from Heterogeneous nuclear ribonucleoprotein A1
Authors:Xie, M., Luo, F., Gui, X., Zhao, M., He, J., Li, D., Liu, C.
Deposit date:2018-03-09
Release date:2019-04-03
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly.
Nat Commun, 10, 2019
5WYD
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STRUCTURAL OF PSEUDOMONAS AERUGINOSA DSPI
Descriptor:Probable enoyl-CoA hydratase/isomerase, PENTANEDIAL, ISOPROPYL ALCOHOL, ...
Authors:Liu, L., Peng, C., Li, T., Li, C., He, L., Song, Y., Zhu, Y., Shen, Y., Bao, R.
Deposit date:2017-01-12
Release date:2018-01-31
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Structural and functional studies on Pseudomonas aeruginosa DspI: implications for its role in DSF biosynthesis.
Sci Rep, 8, 2018
5YFE
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ENZYMATIC AND STRUCTURAL CHARACTERIZATION OF THE POLY (ETHYLENE TEREPHTHALATE) HYDROLASE PETASE FROM I. SAKAIENSIS
Descriptor:Poly(ethylene terephthalate) hydrolase, SULFATE ION, GLYCEROL
Authors:Bao, R., He, L.H., Liu, B.
Deposit date:2017-09-21
Release date:2018-09-26
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Protein Crystallography and Site-Direct Mutagenesis Analysis of the Poly(ethylene terephthalate) Hydrolase PETase from Ideonella sakaiensis.
Chembiochem, 2018
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