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5N81
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CRYSTAL STRUCTURE OF AN ENGINEERED TYCA VARIANT IN COMPLEX WITH AN O-PROPARGYL-BETA-TYR-AMP ANALOG
Descriptor:Tyrocidine synthase 1, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(3~{S})-3-azanyl-3-(4-prop-2-ynoxyphenyl)propanoyl]sulfamate, SULFATE ION, ...
Authors:Niquille, D.L., Hansen, D.A., Mori, T., Fercher, D., Kries, H., Hilvert, D.
Deposit date:2017-02-22
Release date:2017-12-13
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Nonribosomal biosynthesis of backbone-modified peptides.
Nat Chem, 10, 2018
5WIS
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH METHYMYCIN AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.7A RESOLUTION
Descriptor:23S ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Almutairi, M.M., Svetlov, M.S., Hansen, D.A., Khabibullina, N.F., Klepacki, D., Kang, H.Y., Sherman, D.H., Vazquez-Laslop, N., Polikanov, Y.S., Mankin, A.S.
Deposit date:2017-07-20
Release date:2018-02-14
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.
Nucleic Acids Res., 45, 2017
5WIT
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PIKROMYCIN AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.6A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Almutairi, M.M., Svetlov, M.S., Hansen, D.A., Khabibullina, N.F., Klepacki, D., Kang, H.Y., Sherman, D.H., Vazquez-Laslop, N., Polikanov, Y.S., Mankin, A.S.
Deposit date:2017-07-20
Release date:2018-02-14
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.
Nucleic Acids Res., 45, 2017
5N82
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CRYSTAL STRUCTURE OF AN ENGINEERED TYCA VARIANT IN COMPLEX WITH AN BETA-PHE-AMP ANALOG
Descriptor:Tyrocidine synthase 1, SULFATE ION, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Niquille, D.L., Hansen, D.L., Mori, T., Fercher, D., Kries, H., Hilvert, D.
Deposit date:2017-02-22
Release date:2017-12-13
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.708 Å)
Cite:Nonribosomal biosynthesis of backbone-modified peptides.
Nat Chem, 10, 2018
3ZK5
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PIKC D50N MUTANT BOUND TO THE 10-DML ANALOG WITH THE 3-(N,N-DIMETHYLAMINO)ETHANOATE ANCHORING GROUP
Descriptor:CYTOCHROME P450 HYDROXYLASE PIKC, PROTOPORPHYRIN IX CONTAINING FE, (3R,4S,5S,7R,9E,11R,12R)-12-ethyl-3,5,7,11-tetramethyl-2,8-dioxooxacyclododec-9-en-4-yl N,N-dimethylglycinate
Authors:Podust, L.M.
Deposit date:2013-01-21
Release date:2014-01-29
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Directing Group-Controlled Regioselectivity in an Enzymatic C-H Bond Oxygenation.
J.Am.Chem.Soc., 136, 2014
4B7S
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PIKC D50N MUTANT BOUND TO THE 10-DML ANALOG WITH THE 3-(N,N- DIMETHYLAMINO)PROPANOATE ANCHORING GROUP
Descriptor:CYTOCHROME P450 HYDROXYLASE PIKC, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ...
Authors:Podust, L.M.
Deposit date:2012-08-21
Release date:2013-08-28
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Directing Group-Controlled Regioselectivity in an Enzymatic C-H Bond Oxygenation.
J.Am.Chem.Soc., 136, 2014
4MYY
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STRUCTURE OF A CLASS 2 DOCKING DOMAIN COMPLEX FROM MODULES CURG AND CURH OF THE CURACIN A POLYKETIDE SYNTHASE
Descriptor:CurG, CurH fusion protein, SULFATE ION
Authors:Whicher, J.R., Smaga, S.S., Smith, J.L.
Deposit date:2013-09-28
Release date:2014-01-29
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis.
Chem.Biol., 20, 2013
4MYZ
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STRUCTURE OF A CLASS 2 DOCKING DOMAIN COMPLEX FROM MODULES CURK AND CURL OF THE CURACIN A POLYKETIDE SYNTHASE
Descriptor:CurK, CurL fusion protein
Authors:Whicher, J.R., Smaga, S.S., Smith, J.L.
Deposit date:2013-09-28
Release date:2014-01-29
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis.
Chem.Biol., 20, 2013
4MZ0
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STRUCTURE OF A KETOSYNTHASE-ACYLTRANSFERASE DI-DOMAIN FROM MODULE CURL OF THE CURACIN A POLYKETIDE SYNTHASE
Descriptor:CurL, CALCIUM ION
Authors:Whicher, J.R., Smaga, S.S., Smith, J.L.
Deposit date:2013-09-28
Release date:2014-01-29
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis.
Chem.Biol., 20, 2013
5OD1
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STRUCTURE OF THE ENGINEERED METALLOESTERASE MID1SC10 COMPLEXED WITH A PHOSPHONATE TRANSITION STATE ANALOGUE
Descriptor:MID1sc10, ZINC ION, [2-oxidanylidene-7-[oxidanyl-[(1~{S})-1-phenylethyl]phosphoryl]oxy-chromen-4-yl]methanesulfonic acid, ...
Authors:Mittl, P.R.E., Studer, S., Hansen, D.A., Hilvert, D.
Deposit date:2017-07-04
Release date:2018-12-12
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:engineered metalloenzyme
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