Author results

1TOZ
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NMR STRUCTURE OF THE HUMAN NOTCH-1 LIGAND BINDING REGION
Descriptor:Neurogenic locus notch homolog protein 1
Authors:Hambleton, S., Valeyev, N.Y., Muranyi, A., Knott, V., Werner, J.M., Mcmichael, A.J., Handford, P.A., Downing, A.K.
Deposit date:2004-06-15
Release date:2004-10-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural and functional properties of the human notch-1 ligand binding region
STRUCTURE, 12, 2004
2BO2
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EGF DOMAINS 1,2,5 OF HUMAN EMR2, A 7-TM IMMUNE SYSTEM MOLECULE, IN COMPLEX WITH CALCIUM.
Descriptor:EGF-LIKE MODULE CONTAINING MUCIN-LIKE HORMONE RECEPTOR-LIKE 2 PRECURSOR, CALCIUM ION, CACODYLATE ION
Authors:Abbott, R.J.M., Spendlove, I., Roversi, P., Teriete, P., Knott, V., Handford, P.A., McDonnell, J.M., Lea, S.M.
Deposit date:2005-04-07
Release date:2006-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and Functional Characterization of a Novel T Cell Receptor Co-Regulatory Protein Complex, Cd97-Cd55.
J.Biol.Chem., 282, 2007
2BOU
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EGF DOMAINS 1,2,5 OF HUMAN EMR2, A 7-TM IMMUNE SYSTEM MOLECULE, IN COMPLEX WITH BARIUM.
Descriptor:EGF-LIKE MODULE CONTAINING MUCIN-LIKE HORMONE RECEPTOR-LIKE 2 PRECURSOR, BARIUM ION, CALCIUM ION, ...
Authors:Abbott, R.J.M., Spendlove, I., Roversi, P., Teriete, P., Knott, V., Handford, P.A., McDonnell, J.M., Lea, S.M.
Deposit date:2005-04-14
Release date:2006-10-18
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Characterization of a Novel T Cell Receptor Co-Regulatory Protein Complex, Cd97-Cd55.
J.Biol.Chem., 282, 2007
2BOX
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EGF DOMAINS 1,2,5 OF HUMAN EMR2, A 7-TM IMMUNE SYSTEM MOLECULE, IN COMPLEX WITH STRONTIUM.
Descriptor:EGF-LIKE MODULE CONTAINING MUCIN-LIKE HORMONE RECEPTOR-LIKE 2 PRECURSOR, STRONTIUM ION, CHLORIDE ION, ...
Authors:Abbott, R.J.M., Spendlove, I., Roversi, P., Teriete, P., Knott, V., Handford, P.A., McDonnell, J.M., Lea, S.M.
Deposit date:2005-04-14
Release date:2006-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Functional Characterization of a Novel T Cell Receptor Co-Regulatory Protein Complex, Cd97-Cd55.
J.Biol.Chem., 282, 2007
5MS9
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SOLUTION STRUCTURE OF HUMAN FIBRILLIN-1 EGF2-EGF3-HYBRID1-CBEGF1 FOUR DOMAIN FRAGMENT
Descriptor:Fibrillin-1, CALCIUM ION
Authors:Robertson, I.B., Redfield, C., Handford, P.A.
Deposit date:2017-01-01
Release date:2017-08-09
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:The N-Terminal Region of Fibrillin-1 Mediates a Bipartite Interaction with LTBP1.
Structure, 25, 2017
1EMN
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NMR STUDY OF A PAIR OF FIBRILLIN CA2+ BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAINS, MINIMIZED AVERAGE STRUCTURE
Descriptor:FIBRILLIN, CALCIUM ION
Authors:Downing, A.K., Campbell, I.D., Handford, P.A.
Deposit date:1996-08-05
Release date:1996-12-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders.
Cell(Cambridge,Mass.), 85, 1996
1EMO
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NMR STUDY OF A PAIR OF FIBRILLIN CA2+ BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAINS, 22 STRUCTURES
Descriptor:FIBRILLIN, CALCIUM ION
Authors:Downing, A.K., Campbell, I.D., Handford, P.A.
Deposit date:1996-08-05
Release date:1996-12-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders.
Cell(Cambridge,Mass.), 85, 1996
1APJ
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NMR STUDY OF THE TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN-LIKE DOMAIN (TB MODULE/8-CYS DOMAIN), NMR, 21 STRUCTURES
Descriptor:FIBRILLIN
Authors:Yuan, X., Downing, A.K., Knott, V., Handford, P.A.
Deposit date:1997-07-22
Release date:1998-01-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the transforming growth factor beta-binding protein-like module, a domain associated with matrix fibrils.
EMBO J., 16, 1997
1HJ7
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NMR STUDY OF A PAIR OF LDL RECEPTOR CA2+ BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAINS, 20 STRUCTURES
Descriptor:LDL RECEPTOR, CALCIUM ION
Authors:Saha, S., Handford, P.A., Campbell, I.D., Downing, A.K.
Deposit date:2001-01-09
Release date:2001-07-11
Last modified:2018-02-14
Method:SOLUTION NMR
Cite:Solution Structure of the Ldl Receptor Egf-Ab Pair: A Paradigm for the Assembly of Tandem Calcium Binding Egf Domains
Structure, 9, 2001
1KSQ
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NMR STUDY OF THE THIRD TB DOMAIN FROM LATENT TRANSFORMING GROWTH FACTOR-BETA BINDING PROTEIN-1
Descriptor:LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN 1
Authors:Lack, J., O'leary, J.M., Knott, V., Yuan, X., Rifkin, D.B., Handford, P.A., Downing, A.K.
Deposit date:2002-01-14
Release date:2003-08-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of the Third TB Domain from LTBP1 Provides Insight into Assembly of the Large Latent Complex that Sequesters Latent TGF-beta.
J.Mol.Biol., 334, 2003
1LMJ
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NMR STUDY OF THE FIBRILLIN-1 CBEGF12-13 PAIR OF CA2+ BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAINS
Descriptor:fibrillin 1, CALCIUM ION
Authors:Smallridge, R.S., Whiteman, P., Werner, J.M., Campbell, I.D., Handford, P.A., Downing, A.K.
Deposit date:2002-05-02
Release date:2003-04-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure and Dynamics of a Calcium Binding Epidermal Growth Factor-like Domain Pair from the Neonatal Region of Human Fibrillin-1.
J.Biol.Chem., 278, 2003
1UZJ
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INTEGRIN BINDING CBEGF22-TB4-CBEGF33 FRAGMENT OF HUMAN FIBRILLIN-1, HOLO FORM.
Descriptor:FIBRILLIN-1, CALCIUM ION
Authors:Lee, S.S.J., Knott, V., Harlos, K., Handford, P.A., Stuart, D.I.
Deposit date:2004-03-12
Release date:2004-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights Into Microfibril Organization
Structure, 12, 2004
1UZK
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INTEGRIN BINDING CBEGF22-TB4-CBEGF33 FRAGMENT OF HUMAN FIBRILLIN-1, CA BOUND TO CBEGF23 DOMAIN ONLY
Descriptor:FIBRILLIN-1, CALCIUM ION
Authors:Lee, S.S.J., Knott, V., Harlos, K., Handford, P.A., Stuart, D.I.
Deposit date:2004-03-13
Release date:2006-05-24
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights Into Microfibril Organization
Structure, 12, 2004
1UZP
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INTEGRIN BINDING CBEGF22-TB4-CBEGF33 FRAGMENT OF HUMAN FIBRILLIN-1, SM BOUND FORM CBEGF23 DOMAIN ONLY.
Descriptor:FIBRILLIN-1, SAMARIUM (III) ION
Authors:Lee, S.S.J., Knott, V., Harlos, K., Handford, P.A., Stuart, D.I.
Deposit date:2004-03-15
Release date:2004-04-08
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights Into Microfibril Organization
Structure, 12, 2004
1UZQ
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INTEGRIN BINDING CBEGF22-TB4-CBEGF33 FRAGMENT OF HUMAN FIBRILLIN-1, APO FORM CBEGF23 DOMAIN ONLY.
Descriptor:FIBRILLIN-1
Authors:Lee, S.S.J., Knott, V., Harlos, K., Handford, P.A., Stuart, D.I.
Deposit date:2004-03-15
Release date:2004-04-08
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights Into Microfibril Organization
Structure, 12, 2004
2M74
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1H, 13C AND 15N ASSIGNMENTS OF THE FOUR N-TERMINAL DOMAINS OF HUMAN FIBRILLIN-1
Descriptor:Fibrillin-1
Authors:Yadin, D.A., Robertson, I.B., Jensen, S.A., Handford, P.A., Redfield, C.
Deposit date:2013-04-17
Release date:2013-09-25
Last modified:2013-11-20
Method:SOLUTION NMR
Cite:Structure of the Fibrillin-1 N-Terminal Domains Suggests that Heparan Sulfate Regulates the Early Stages of Microfibril Assembly.
Structure, 21, 2013
2VJ2
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HUMAN JAGGED-1, DOMAINS DSL AND EGFS1-3
Descriptor:JAGGED-1, D-MALATE
Authors:Johnson, S., Cordle, J., Tay, J.Z., Roversi, P., Handford, P.A., Lea, S.M.
Deposit date:2007-12-06
Release date:2008-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Conserved Face of the Jagged/Serrate Dsl Domain is Involved in Notch Trans-Activation and Cis-Inhibition.
Nat.Struct.Mol.Biol., 15, 2008
2W86
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CRYSTAL STRUCTURE OF FIBRILLIN-1 DOMAINS CBEGF9HYB2CBEGF10, CALCIUM SATURATED FORM
Descriptor:FIBRILLIN-1, CALCIUM ION, IODIDE ION
Authors:Jensen, S.A., Iqbal, S., Lowe, E.D., Redfield, C., Handford, P.A.
Deposit date:2009-01-09
Release date:2009-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and Interdomain Interactions of a Hybrid Domain: A Disulphide-Rich Module of the Fibrillin/Ltbp Superfamily of Matrix Proteins.
Structure, 17, 2009
4CBZ
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NOTCH LIGAND, JAGGED-1, CONTAINS AN N-TERMINAL C2 DOMAIN
Descriptor:PROTEIN JAGGED-1, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE
Authors:Chilakuri, C.R., Sheppard, D., Ilagan, M.X.G., Holt, L.R., Abbott, F., Liang, S., Kopan, R., Handford, P.A., Lea, S.M.
Deposit date:2013-10-17
Release date:2013-11-27
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands
Cell Rep., 5, 2013
4CC0
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NOTCH LIGAND, JAGGED-1, CONTAINS AN N-TERMINAL C2 DOMAIN
Descriptor:PROTEIN JAGGED-1, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Chilakuri, C.R., Sheppard, D., Ilagan, M.X.G., Holt, L.R., Abbott, F., Liang, S., Kopan, R., Handford, P.A., Lea, S.M.
Deposit date:2013-10-17
Release date:2013-11-27
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands
Cell Rep., 5, 2013
4CC1
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NOTCH LIGAND, JAGGED-1, CONTAINS AN N-TERMINAL C2 DOMAIN
Descriptor:PROTEIN JAGGED-1, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Chilakuri, C.R., Sheppard, D., Ilagan, M.X.G., Holt, L.R., Abbott, F., Liang, S., Kopan, R., Handford, P.A., Lea, S.M.
Deposit date:2013-10-17
Release date:2013-11-27
Last modified:2013-12-25
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands
Cell Rep., 5, 2013
4CUD
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HUMAN NOTCH1 EGF DOMAINS 11-13 MUTANT FUCOSYLATED AT T466
Descriptor:NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1, ALPHA-L-FUCOSE, CALCIUM ION
Authors:Taylor, P., Takeuchi, H., Sheppard, D., Chillakuri, C., Lea, S.M., Haltiwanger, R.S., Handford, P.A.
Deposit date:2014-03-18
Release date:2014-05-21
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Proc.Natl.Acad.Sci.USA, 111, 2014
4CUE
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HUMAN NOTCH1 EGF DOMAINS 11-13 MUTANT T466V
Descriptor:NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1, CALCIUM ION
Authors:Taylor, P., Takeuchi, H., Sheppard, D., Chillakuri, C., Lea, S.M., Haltiwanger, R.S., Handford, P.A.
Deposit date:2014-03-18
Release date:2014-05-21
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Proc.Natl.Acad.Sci.USA, 111, 2014
4CUF
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HUMAN NOTCH1 EGF DOMAINS 11-13 MUTANT T466S
Descriptor:NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1, CALCIUM ION, 1,2-ETHANEDIOL
Authors:Taylor, P., Takeuchi, H., Sheppard, D., Chillakuri, C., Lea, S.M., Haltiwanger, R.S., Handford, P.A.
Deposit date:2014-03-18
Release date:2014-05-14
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Proc.Natl.Acad.Sci.USA, 111, 2014
4D0E
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HUMAN NOTCH1 EGF DOMAINS 11-13 MUTANT GLCNAC-FUCOSE DISACCHARIDE MODIFIED AT T466
Descriptor:NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Taylor, P., Takeuchi, H., Sheppard, D., Chillakuri, C., Lea, S.M., Haltiwanger, R.S., Handford, P.A.
Deposit date:2014-04-25
Release date:2014-05-21
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Proc.Natl.Acad.Sci.USA, 111, 2014
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