Author results

6U8A
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CBD-BOUND FULL-LENGTH RAT TRPV2 IN NANODISCS, STATE 1
分子名称:Transient receptor potential cation channel subfamily V member 2, cannabidiol
著者Pumroy, R.A., Moiseenkova-Bell, V.Y.
登録日2019-09-04
公開日2019-10-16
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Molecular mechanism of TRPV2 channel modulation by cannabidiol.
Elife, 8, 2019
6U88
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CBD-BOUND FULL-LENGTH RAT TRPV2 IN NANODISCS, STATE 2
分子名称:Transient receptor potential cation channel subfamily V member 2, cannabidiol
著者Pumroy, R.A., Moiseenkova-Bell, V.Y.
登録日2019-09-04
公開日2019-10-16
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Molecular mechanism of TRPV2 channel modulation by cannabidiol.
Elife, 8, 2019
6U86
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APO FULL-LENGTH RAT TRPV2 IN NANODISCS, STATE 2
分子名称:Transient receptor potential cation channel subfamily V member 2
著者Pumroy, R.A., Moiseenkova-Bell, V.Y.
登録日2019-09-04
公開日2019-10-16
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Molecular mechanism of TRPV2 channel modulation by cannabidiol.
Elife, 8, 2019
6U84
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APO FULL-LENGTH RAT TRPV2 IN NANODISCS, STATE 1
分子名称:Transient receptor potential cation channel subfamily V member 2
著者Pumroy, R.A., Moiseenkova-Bell, V.Y.
登録日2019-09-04
公開日2019-10-16
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Molecular mechanism of TRPV2 channel modulation by cannabidiol.
Elife, 8, 2019
6NZU
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STRUCTURE OF THE HUMAN FRATAXIN-BOUND IRON-SULFUR CLUSTER ASSEMBLY COMPLEX
分子名称:Cysteine desulfurase, mitochondrial, LYR motif-containing protein 4, ...
著者Fox, N.G., Yu, X., Xidong, F., Alain, M., Joseph, N., Claire, S.D., Christine, B., Han, S., Yue, W.W.
登録日2019-02-14
公開日2019-05-22
最終更新日2019-07-10
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism.
Nat Commun, 10, 2019
6MPB
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CRYO-EM STRUCTURE OF THE HUMAN NEUTRAL AMINO ACID TRANSPORTER ASCT2
分子名称:Neutral amino acid transporter B(0), GLUTAMINE, N-ACETYL-D-GLUCOSAMINE
著者Yu, X., Han, S.
登録日2018-10-05
公開日2019-11-06
最終更新日2019-11-27
実験手法ELECTRON MICROSCOPY (3.84 Å)
主引用文献Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation.
Elife, 8, 2019
6MP6
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CRYO-EM STRUCTURE OF THE HUMAN NEUTRAL AMINO ACID TRANSPORTER ASCT2
分子名称:Neutral amino acid transporter B(0), N-ACETYL-D-GLUCOSAMINE
著者Yu, X., Han, S.
登録日2018-10-05
公開日2019-11-06
最終更新日2019-11-27
実験手法ELECTRON MICROSCOPY (3.54 Å)
主引用文献Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation.
Elife, 8, 2019
6MNY
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CRYSTAL STRUCTURE OF MOUSE BTK KINASE DOMAIN IN COMPLEX WITH COMPOUND 9A
分子名称:Tyrosine-protein kinase, 5-amino-1-[(3R)-1-cyanopiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazole-4-carboxamide
著者Han, S., Caspers, N., Ohren, J.O.
登録日2018-10-03
公開日2019-01-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.
ACS Med Chem Lett, 10, 2019
6J0L
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CRYSTAL STRUCTURE OF INTRACELLULAR B30.2 DOMAIN OF BTN3A3 MUTANT IN COMPLEX WITH SULFATE ION
分子名称:Butyrophilin subfamily 3 member A3, SULFATE ION
著者Yang, Y.Y., Liu, W.D., Cai, N.N., Chen, C.C., Guo, R.T., Zhang, Y.H.
登録日2018-12-24
公開日2019-04-03
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation.
Immunity, 50, 2019
6J0K
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CRYSTAL STRUCTURE OF INTRACELLULAR B30.2 DOMAIN OF BTN3A3 MUTANT IN COMPLEX WITH HMBPP
分子名称:Butyrophilin subfamily 3 member A3, (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate
著者Yang, Y.Y., Liu, W.D., Cai, N.N., Chen, C.C., Guo, R.T., Zhang, Y.H.
登録日2018-12-24
公開日2019-04-03
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation.
Immunity, 50, 2019
6J0G
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CRYSTAL STRUCTURE OF INTRACELLULAR B30.2 DOMAIN OF BTN3A3 MUTANT IN COMPLEX WITH HMBPP
分子名称:Butyrophilin subfamily 3 member A3, (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate
著者Yang, Y.Y., Liu, W.D., Cai, N.N., Chen, C.C., Guo, R.T., Zhang, Y.H.
登録日2018-12-24
公開日2019-04-03
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation.
Immunity, 50, 2019
6J06
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CRYSTAL STRUCTURE OF INTRACELLULAR B30.2 DOMAIN OF BTN3A1 IN COMPLEX WITH HMBPP-08
分子名称:Butyrophilin subfamily 3 member A1, (2E)-3-(hydroxymethyl)-4-(4-methylphenyl)but-2-en-1-yl trihydrogen diphosphate, SULFATE ION, ...
著者Yang, Y.Y., Liu, W.D., Cai, N.N., Chen, C.C., Guo, R.T., Zhang, Y.H.
登録日2018-12-21
公開日2019-04-03
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation.
Immunity, 50, 2019
6ITA
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CRYSTAL STRUCTURE OF INTRACELLULAR B30.2 DOMAIN OF BTN3A1 MUTANT
分子名称:Butyrophilin subfamily 3 member A1
著者Yang, Y.Y., Liu, W.D., Cai, N.N., Chen, C.C., Guo, R.T., Zhang, Y.H.
登録日2018-11-20
公開日2019-04-03
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation.
Immunity, 50, 2019
6ISM
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CRYSTAL STRUCTURE OF INTRACELLULAR B30.2 DOMAIN OF BTN3A1 MUTANT
分子名称:Butyrophilin subfamily 3 member A1
著者Yang, Y.Y., Liu, W.D., Cai, N.N., Chen, C.C., Guo, R.T., Zhang, Y.H.
登録日2018-11-16
公開日2019-04-03
最終更新日2019-05-01
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation.
Immunity, 50, 2019
6IIV
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CRYSTAL STRUCTURE OF THE HUMAN THROMBOXANE A2 RECEPTOR BOUND TO DALTROBAN
分子名称:Soluble cytochrome b562,Thromboxane A2 receptor,Rubredoxin,Thromboxane A2 receptor, 2-[4-[2-[(4-chlorophenyl)sulfonylamino]ethyl]phenyl]ethanoic acid, ZINC ION, ...
著者Fan, H., Zhao, Q., Wu, B.
登録日2018-10-07
公開日2018-12-19
最終更新日2018-12-26
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural basis for ligand recognition of the human thromboxane A2receptor.
Nat. Chem. Biol., 15, 2019
6IIU
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CRYSTAL STRUCTURE OF THE HUMAN THROMBOXANE A2 RECEPTOR BOUND TO RAMATROBAN
分子名称:Soluble cytochrome b562,Thromboxane A2 receptor,Rubredoxin,Thromboxane A2 receptor, 3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid, ZINC ION, ...
著者Fan, H., Zhao, Q., Wu, B.
登録日2018-10-07
公開日2018-12-19
最終更新日2018-12-26
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for ligand recognition of the human thromboxane A2receptor.
Nat. Chem. Biol., 15, 2019
6BY9
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CRYSTAL STRUCTURE OF EHMT1
分子名称:Histone-lysine N-methyltransferase EHMT1, UNKNOWN ATOM OR ION
著者Dong, A., Wei, Y., Li, A., Tempel, W., Han, S., Sunnerhagen, M., Penn, L., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
登録日2017-12-20
公開日2018-01-31
最終更新日2018-10-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of EHMT1
to be published
6BBV
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CRYSTAL STRUCTURE OF JAK2 IN COMPLEX WITH COMPOUND 25
分子名称:Tyrosine-protein kinase JAK2, N-{cis-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide
著者Han, S.
登録日2017-10-19
公開日2018-01-17
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.
J. Med. Chem., 61, 2018
6BBU
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CRYSTAL STRUCTURE OF JAK1 IN COMPLEX WITH COMPOUND 25
分子名称:Tyrosine-protein kinase JAK1, N-{cis-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide
著者Han, S.
登録日2017-10-19
公開日2018-01-17
最終更新日2018-02-21
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.
J. Med. Chem., 61, 2018
6B5V
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STRUCTURE OF TRPV5 IN COMPLEX WITH ECONAZOLE
分子名称:Transient receptor potential cation channel subfamily V member 5, 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, CALCIUM ION
著者Hughes, T.E.T., Lodowski, D.T., Huynh, K.W., Yazici, A., del Rosario, J., Kapoor, A., Basak, S., Samanta, A., Chakrapani, S., Zhou, Z.H., Filizola, M., Rohacs, T., Han, S., Moiseenkova-Bell, V.Y.
登録日2017-09-29
公開日2017-12-27
最終更新日2018-01-31
実験手法ELECTRON MICROSCOPY (4.8 Å)
主引用文献Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM.
Nat. Struct. Mol. Biol., 25, 2018
6A9F
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CRYSTAL STRUCTURE OF A CYCLASE FROM FISCHERELLA SP. TAU IN COMPLEX WITH 4-(1H-INDOL-3-YL)BUTAN-2-ONE
分子名称:aromatic prenyltransferase, MAGNESIUM ION, CALCIUM ION, ...
著者Hu, X.Y., Liu, W.D., Chen, C.C., Guo, R.T.
登録日2018-07-13
公開日2018-12-19
最終更新日2018-12-26
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement
Angew. Chem. Int. Ed. Engl., 57, 2018
6A99
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CRYSTAL STRUCTURE OF A STIG CYCLASES FISC FROM FISCHERELLA SP. TAU IN COMPLEX WITH (3Z)-3-(1-METHYL-2-PYRROLIDINYLIDENE)-3H-INDOLE
分子名称:aromatic prenyltransferase, (3~{Z})-3-(1-methylpyrrolidin-2-ylidene)indole, CALCIUM ION, ...
著者Hu, X.Y., Liu, W.D., Chen, C.C., Guo, R.T.
登録日2018-07-12
公開日2018-12-19
最終更新日2018-12-26
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement
Angew. Chem. Int. Ed. Engl., 57, 2018
6A98
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CRYSTAL STRUCTURE OF A CYCLASE FROM FISCHERELLA SP. TAU
分子名称:aromatic prenyltransferase, B-OCTYLGLUCOSIDE, CALCIUM ION, ...
著者Hu, X.Y., Liu, W.D., Chen, C.C., Guo, R.T.
登録日2018-07-12
公開日2018-12-19
最終更新日2018-12-26
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement
Angew. Chem. Int. Ed. Engl., 57, 2018
6A92
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CRYSTAL STRUCTURE OF A CYCLASE FILC1 FROM FISCHERELLA SP.
分子名称:acyclase, CALCIUM ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
著者Hu, X.Y., Liu, W.D., Chen, C.C., Guo, R.T.
登録日2018-07-11
公開日2018-12-19
最終更新日2018-12-26
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement
Angew. Chem. Int. Ed. Engl., 57, 2018
6A8X
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CRYSTAL STRUCTURE OF A APO FORM CYCLASE FROM FISCHERELLA SP.
分子名称:aromatic prenyltransferase, CALCIUM ION
著者Hu, X.Y., Liu, W.D., Chen, C.C., Guo, R.T.
登録日2018-07-11
公開日2018-12-19
最終更新日2018-12-26
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement
Angew. Chem. Int. Ed. Engl., 57, 2018