Author results

4L29
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STRUCTURE OF WTMHC CLASS I WITH NY-ESO1 DOUBLE MUTANT
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Halabelian, L., Giorgetti, S., Bellotti, V., Bolognesi, M., Ricagno, S.
Deposit date:2013-06-04
Release date:2013-12-25
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic beta 2-Microglobulin.
J.Biol.Chem., 289, 2014
4L3C
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STRUCTURE OF HLA-A2 IN COMPLEX WITH D76N B2M MUTANT AND NY-ESO1 DOUBLE MUTANT
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Halabelian, L., Giorgetti, S., Bellotti, V., Bolognesi, M., Ricagno, S.
Deposit date:2013-06-05
Release date:2013-12-25
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic beta 2-Microglobulin.
J.Biol.Chem., 289, 2014
5KO9
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CRYSTAL STRUCTURE OF THE SRAP DOMAIN OF HUMAN HMCES PROTEIN
Descriptor:Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, UNKNOWN ATOM OR ION
Authors:Halabelian, L., Li, Y., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2016-06-29
Release date:2016-08-24
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Basis of HMCES Interactions with Abasic DNA and Multivalent Substrate Recognition
Nat.Struct.Mol.Biol., 2019
6OE7
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CRYSTAL STRUCTURE OF HMCES CROSS-LINKED TO DNA ABASIC SITE
Descriptor:Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, DNA (5'-D(*GP*TP*CP*TP*GP*G)-3'), DNA (5'-D(*CP*CP*AP*GP*AP*CP*GP*TP*(DRZ)P*GP*TP*T)-3'), ...
Authors:Halabelian, L., Li, Y., Zeng, H., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2019-03-27
Release date:2019-04-24
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.
Nat.Struct.Mol.Biol., 26, 2019
6OEA
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CRYSTAL STRUCTURE OF HMCES SRAP DOMAIN IN COMPLEX WITH LONGER 3' OVERHANG DNA
Descriptor:Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, DNA (5'-D(*CP*CP*AP*GP*AP*CP*GP*TP*TP*GP*TP*T)-3'), DNA (5'-D(*GP*TP*CP*TP*GP*G)-3'), ...
Authors:Halabelian, L., Ravichandran, M., Li, Y., Zeng, H., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2019-03-27
Release date:2019-04-10
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.
Nat.Struct.Mol.Biol., 26, 2019
6OEB
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CRYSTAL STRUCTURE OF HMCES SRAP DOMAIN IN COMPLEX WITH 3' OVERHANG DNA
Descriptor:Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, DNA (5'-D(*CP*CP*AP*GP*AP*CP*GP*TP*T)-3'), DNA (5'-D(*GP*TP*CP*TP*GP*G)-3'), ...
Authors:Halabelian, L., Ravichandran, M., Li, Y., Zeng, H., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2019-03-27
Release date:2019-04-10
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.
Nat.Struct.Mol.Biol., 26, 2019
4R9H
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CRYSTAL STRUCTURE OF DIMERIC S33C BETA-2 MICROGLOBULIN MUTANT AT 1.9 ANGSTROM RESOLUTION
Descriptor:Beta-2-microglobulin
Authors:Halabelian, L., Bolognesi, M., Ricagno, S.
Deposit date:2014-09-05
Release date:2015-09-09
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A covalent homodimer probing early oligomers along amyloid aggregation.
Sci Rep, 5, 2015
4RA3
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CRYSTAL STRUCTURE OF DIMERIC S33C BETA-2 MICROGLOBULIN MUTANT IN COMPLEX WITH THIOFLAVIN (THT) AT 2.8 ANGSTROM RESOLUTION
Descriptor:Beta-2-microglobulin, 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium
Authors:Halabelian, L., Bolognesi, M., Ricagno, S.
Deposit date:2014-09-09
Release date:2015-09-09
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A covalent homodimer probing early oligomers along amyloid aggregation.
Sci Rep, 5, 2015
4RAH
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CRYSTAL STRUCTURE OF DIMERIC S33C BETA-2 MICROGLOBULIN MUTANT AT 1.4 ANGSTROM RESOLUTION
Descriptor:Beta-2-microglobulin
Authors:Halabelian, L., Bolognesi, M., Ricagno, S.
Deposit date:2014-09-10
Release date:2015-09-16
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A covalent homodimer probing early oligomers along amyloid aggregation.
Sci Rep, 5, 2015
5J3E
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CRYSTAL STRUCTURE OF HUMAN THYN1 PROTEIN IN COMPLEX WITH 5-METHYLCYTOSINE CONTAINING DNA
Descriptor:Thymocyte nuclear protein 1, 5-methylcytosine containing DNA, UNKNOWN ATOM OR ION
Authors:Halabelian, L., Tempel, W., Li, Y., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2016-03-30
Release date:2016-04-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Human THYN1 protein in complex with 5-methylcytosine containing DNA
To be published
5WBV
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CRYSTAL STRUCTURE OF THE SET DOMAIN OF HUMAN SUV420H1 IN COMPLEX WITH INHIBITOR
Descriptor:Histone-lysine N-methyltransferase KMT5B, ZINC ION, S-ADENOSYLMETHIONINE, ...
Authors:Halabelian, L., Tempel, W., Brown, P.J., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2017-06-29
Release date:2017-07-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of the SET Domain of Human SUV420H1 In Complex With Inhibitor
To be published
6MIW
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WWE DOMAIN OF HUMAN HUWE1
Descriptor:E3 ubiquitin-protein ligase HUWE1, UNKNOWN ATOM OR ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Halabelian, L., Loppnau, P., Tempel, W., Wong, F., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2018-09-20
Release date:2018-10-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:WWE domain of human HUWE1
To Be Published
6N31
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WD REPEATS OF HUMAN WDR12
Descriptor:Ribosome biogenesis protein WDR12, UNKNOWN ATOM OR ION
Authors:Halabelian, L., Zeng, H., Tempel, W., Li, Y., Seitova, A., Hutchinson, A., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2018-11-14
Release date:2018-12-12
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:WD repeats of human WDR12
To Be Published
6OGN
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CRYSTAL STRUCTURE OF MOUSE PROTEIN ARGININE METHYLTRANSFERASE 7 IN COMPLEX WITH SGC8158 CHEMICAL PROBE
Descriptor:Protein arginine N-methyltransferase 7, ZINC ION, 5'-S-(4-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}butyl)-5'-thioadenosine, ...
Authors:Halabelian, L., Dong, A., Zeng, H., Li, Y., Hutchinson, A., Seitova, A., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2019-04-03
Release date:2019-04-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of mouse protein arginine methyltransferase 7 in complex with SGC8158 chemical probe
To be Published
6OOV
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CRYSTAL STRUCTURE OF HMCES SRAP DOMAIN IN COMPLEX WITH PALINDROMIC 3' OVERHANG DNA
Descriptor:Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, DNA (5'-D(*CP*AP*AP*CP*GP*TP*TP*GP*TP*TP*TP*TP*T)-3'), UNKNOWN ATOM OR ION
Authors:Halabelian, L., Zeng, H., Li, Y., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2019-04-23
Release date:2019-05-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of HMCES SRAP domain in complex with palindromic 3' overhang DNA
To Be Published
6P0Q
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CRYSTAL STRUCTURE OF UBIQUITIN-LIKE DOMAIN OF HUMAN WDR12
Descriptor:Ribosome biogenesis protein WDR12, 1,2-ETHANEDIOL
Authors:Halabelian, L., Dong, A., Zeng, H., Li, Y., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2019-05-17
Release date:2019-05-29
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Crystal Structure of Ubiquitin-like Domain of Human WDR12
to be published
6P0R
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METHYLTRANSFERASE DOMAIN OF HUMAN SUPPRESSOR OF VARIEGATION 3-9 HOMOLOG 2 (SUV39H2) IN COMPLEX WITH OTS186935 INHIBITOR
Descriptor:Histone-lysine N-methyltransferase SUV39H2, (3S)-1-[2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl]-N-[(pyridin-4-yl)methyl]pyrrolidin-3-amine, ZINC ION, ...
Authors:Halabelian, L., Dong, A., Zeng, H., Loppnau, P., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2019-05-17
Release date:2019-05-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Methyltransferase domain of human suppressor of variegation 3-9 homolog 2 (SUV39H2) in complex with OTS186935 inhibitor
to be published
6P7I
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CRYSTAL STRUCTURE OF HUMAN PRMT6 IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE AND YS17-117 COMPOUND
Descriptor:Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, N-[3-(4-{[(2-aminoethyl)(methyl)amino]methyl}-1H-pyrrol-3-yl)phenyl]prop-2-enamide, ...
Authors:Halabelian, L., Dong, A., Zeng, H., Li, Y., Seitova, A., Hutchinson, A., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2019-06-05
Release date:2019-06-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of Human PRMT6 in complex with S-Adenosyl-L-Homocysteine and YS17-117 Comp ound
to be published
6PBG
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CRYSTAL STRUCTURE OF WD-REPEAT DOMAIN OF HUMAN COATOMER SUBUNIT ALPHA (COPA)
Descriptor:Coatomer subunit alpha, L(+)-TARTARIC ACID, UNKNOWN ATOM OR ION
Authors:Halabelian, L., Zeng, H., Dong, A., Loppnau, P., Seitova, A., Hutchinson, A., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2019-06-13
Release date:2019-06-26
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Crystal structure of W repeat domain of human coatomer subunit Alpha (COPA)
to be published
6PDM
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CRYSTAL STRUCTURE OF HUMAN PROTEIN ARGININE METHYLTRANSFERASE 9 (PRMT9)
Descriptor:Protein arginine N-methyltransferase 9, UNKNOWN ATOM OR ION
Authors:Halabelian, L., Tempel, W., Zeng, H., Li, Y., Seitova, A., Hutchinson, A., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2019-06-19
Release date:2019-07-31
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of Human Protein Arginine Methyltransferase 9 (PRMT9)
To Be Published
6PFL
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CRYSTAL STRUCTURE OF HUMAN HUWE1 WWE DOMAIN IN COMPLEX WITH ADPR
Descriptor:E3 ubiquitin-protein ligase HUWE1, ADENOSINE-5-DIPHOSPHORIBOSE, UNKNOWN ATOM OR ION
Authors:Halabelian, L., Zeng, H., Dong, A., Loppnau, P., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2019-06-21
Release date:2019-07-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of Human HUWE1 WWE domain in complex with ADPR
to be published
6UHD
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CRYSTAL STRUCTURE OF HUMAN HISTONE ACETYLTRANSFERASE 1 (HAT1) IN COMPLEX WITH ISOBUTYRYL-COA AND K12A MUTANT VARIANT OF HISTONE PEPTIDE H4
Descriptor:Histone acetyltransferase type B catalytic subunit, Histone H4, ACETATE ION, ...
Authors:Halabelian, L., Zeng, H., Dong, A., Loppnau, P., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2019-09-27
Release date:2019-10-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of human histone acetyltransferase 1 (HAT1) in complex with Isobutyryl-CoA and K12A mutant variant of histone peptide H4
to be published
5WCJ
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CRYSTAL STRUCTURE OF HUMAN METHYLTRANSFERASE-LIKE PROTEIN 13 IN COMPLEX WITH SAH
Descriptor:Methyltransferase-like protein 13, UNKNOWN ATOM OR ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Halabelian, L., Loppnau, P., Seitova, A., Hutchinson, A., Hunt, B., Dong, A., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2017-06-30
Release date:2017-07-19
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates.
Nat Commun, 9, 2018
5WAX
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CRYSTAL STRUCTURE OF SUGARCANE SAPK10 (SERINE/THREONINE-PROTEIN KINASE 10)
Descriptor:SAPK10 (serine/threonine-protein kinase 10), GLYCEROL
Authors:Righetto, G.L., Counago, R.M., Halabelian, L., Santiago, A.S., Massirer, K.B., Arruda, P., Gileadi, O., Menossi, M., Edwards, A.M., Elkins, J.M., Structural Genomics Consortium (SGC)
Deposit date:2017-06-27
Release date:2018-08-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Sugarcane SAPK10 (serine/threonine-protein kinase 10)
To Be Published
6BW3
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CRYSTAL STRUCTURE OF RBBP4 IN COMPLEX WITH PRDM3 N-TERMINAL PEPTIDE
Descriptor:Histone-binding protein RBBP4, MDS1 and EVI1 complex locus protein MDS1, UNKNOWN ATOM OR ION
Authors:Ivanochko, D., Halabelian, L., Hutchinson, A., Seitova, A., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2017-12-14
Release date:2017-12-27
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.
Nucleic Acids Res., 47, 2019
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