Author results

1VBA
  • Download 1vba
  • View 1vba
Molmil generated image of 1vba
POLIOVIRUS (TYPE 3, SABIN STRAIN) (P3/SABIN, P3/LEON/12A(1)B) COMPLEXED WITH R78206
Descriptor:POLIOVIRUS TYPE 3, (METHYLPYRIDAZINE PIPERIDINE PROPYLOXYPHENYL)ETHYLACETATE, MYRISTIC ACID
Authors:Grant, R.A., Hiremath, C.N., Filman, D.J., Syed, R., Andries, K., Hogle, J.M.
Deposit date:1996-01-02
Release date:1996-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of poliovirus complexes with anti-viral drugs: implications for viral stability and drug design.
Curr.Biol., 4, 1994
1VBB
  • Download 1vbb
  • View 1vbb
Molmil generated image of 1vbb
POLIOVIRUS (TYPE 3, SABIN STRAIN) (P3/SABIN, P3/LEON/12A(1)B) COMPLEXED WITH R80633
Descriptor:POLIOVIRUS TYPE 3, (METHYLPYRIDAZINE PIPERIDINE BUTYLOXYPHENYL)ETHYLACETATE, MYRISTIC ACID
Authors:Grant, R.A., Hiremath, C.N., Filman, D.J., Syed, R., Andries, K., Hogle, J.M.
Deposit date:1996-01-02
Release date:1996-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of poliovirus complexes with anti-viral drugs: implications for viral stability and drug design.
Curr.Biol., 4, 1994
1VBC
  • Download 1vbc
  • View 1vbc
Molmil generated image of 1vbc
POLIOVIRUS (TYPE 3, SABIN STRAIN) (P3/SABIN, P3/LEON/12A(1)B) COMPLEXED WITH R77975
Descriptor:POLIOVIRUS TYPE 3, (METHYLPYRIDAZINE PIPERIDINE ETHYLOXYPHENYL)ETHYLACETATE, MYRISTIC ACID
Authors:Grant, R.A., Hiremath, C.N., Filman, D.J., Syed, R., Andries, K., Hogle, J.M.
Deposit date:1996-01-02
Release date:1996-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of poliovirus complexes with anti-viral drugs: implications for viral stability and drug design.
Curr.Biol., 4, 1994
1VBD
  • Download 1vbd
  • View 1vbd
Molmil generated image of 1vbd
POLIOVIRUS (TYPE 1, MAHONEY STRAIN) COMPLEXED WITH R78206
Descriptor:POLIOVIRUS TYPE 1 MAHONEY, (METHYLPYRIDAZINE PIPERIDINE PROPYLOXYPHENYL)ETHYLACETATE, MYRISTIC ACID
Authors:Grant, R.A., Hiremath, C.N., Filman, D.J., Syed, R., Andries, K., Hogle, J.M.
Deposit date:1996-01-02
Release date:1996-07-11
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of poliovirus complexes with anti-viral drugs: implications for viral stability and drug design.
Curr.Biol., 4, 1994
1VBE
  • Download 1vbe
  • View 1vbe
Molmil generated image of 1vbe
POLIOVIRUS (TYPE 3, SABIN STRAIN, MUTANT 242-H2) COMPLEXED WITH R78206
Descriptor:POLIOVIRUS TYPE 3, (METHYLPYRIDAZINE PIPERIDINE PROPYLOXYPHENYL)ETHYLACETATE, MYRISTIC ACID
Authors:Grant, R.A., Hiremath, C.N., Filman, D.J., Syed, R., Andries, K., Hogle, J.M.
Deposit date:1996-01-02
Release date:1996-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of poliovirus complexes with anti-viral drugs: implications for viral stability and drug design.
Curr.Biol., 4, 1994
1DPS
  • Download 1dps
  • View 1dps
Molmil generated image of 1dps
THE CRYSTAL STRUCTURE OF DPS, A FERRITIN HOMOLOG THAT BINDS AND PROTECTS DNA
Descriptor:DPS, SODIUM ION
Authors:Grant, R.A., Filman, D.J., Finkel, S.E., Kolter, R., Hogle, J.M.
Deposit date:1998-02-23
Release date:1998-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The crystal structure of Dps, a ferritin homolog that binds and protects DNA.
Nat.Struct.Biol., 5, 1998
1DU0
  • Download 1du0
  • View 1du0
Molmil generated image of 1du0
ENGRAILED HOMEODOMAIN Q50A VARIANT DNA COMPLEX
Descriptor:DNA (5'-D(*TP*TP*TP*TP*GP*CP*CP*AP*TP*GP*TP*AP*AP*TP*TP*AP*CP*CP*TP*AP*A)-3'), DNA (5'-D(*AP*TP*TP*AP*GP*GP*TP*AP*AP*TP*TP*AP*CP*AP*TP*GP*GP*CP*AP*AP*A)-3'), ENGRAILED HOMEODOMAIN
Authors:Grant, R.A., Rould, M.A., Klemm, J.D., Pabo, C.O.
Deposit date:2000-01-13
Release date:2000-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Exploring the role of glutamine 50 in the homeodomain-DNA interface: crystal structure of engrailed (Gln50 --> ala) complex at 2.0 A.
Biochemistry, 39, 2000
1TME
  • Download 1tme
  • View 1tme
Molmil generated image of 1tme
THREE-DIMENSIONAL STRUCTURE OF THEILER VIRUS
Descriptor:THEILER'S MURINE ENCEPHALOMYELITIS VIRUS (SUBUNIT VP1), THEILER'S MURINE ENCEPHALOMYELITIS VIRUS (SUBUNIT VP2), THEILER'S MURINE ENCEPHALOMYELITIS VIRUS (SUBUNIT VP3), ...
Authors:Grant, R.A., Filman, D.J., Hogle, J.M.
Deposit date:1992-01-30
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Three-dimensional structure of Theiler virus.
Proc.Natl.Acad.Sci.USA, 89, 1992
3B8J
  • Download 3b8j
  • View 3b8j
Molmil generated image of 3b8j
Q191A MUTANT OF DEGS-DELTAPDZ
Descriptor:Protease degS
Authors:Grant, R.A., Sohn, J., Sauer, R.T.
Deposit date:2007-11-01
Release date:2008-09-16
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.507 Å)
Cite:biochemical characterization of DegS-deltaPDZ q191A mutant
To be Published
5JI2
  • Download 5ji2
  • View 5ji2
Molmil generated image of 5ji2
HSLU L199Q IN HSLUV COMPLEX
Descriptor:ATP-dependent protease subunit HslV, ATP-dependent protease ATPase subunit HslU, MAGNESIUM ION, ...
Authors:Grant, R.A., Sauer, R.T., Schmitz, K.R., Baytshtok, V.
Deposit date:2016-04-21
Release date:2016-11-30
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (3.307 Å)
Cite:A Structurally Dynamic Region of the HslU Intermediate Domain Controls Protein Degradation and ATP Hydrolysis.
Structure, 24, 2016
5JI3
  • Download 5ji3
  • View 5ji3
Molmil generated image of 5ji3
HSLUV COMPLEX
Descriptor:ATP-dependent protease subunit HslV, ATP-dependent protease ATPase subunit HslU, 2'-DEOXYADENOSINE-5'-DIPHOSPHATE
Authors:Grant, R.A., Sauer, R.T., Schmitz, K.R., Baytshtok, V.
Deposit date:2016-04-21
Release date:2016-12-07
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:A Structurally Dynamic Region of the HslU Intermediate Domain Controls Protein Degradation and ATP Hydrolysis.
Structure, 24, 2016
5TXV
  • Download 5txv
  • View 5txv
Molmil generated image of 5txv
HSLU P21 CELL WITH 4 HEXAMERS
Descriptor:ATP-dependent protease ATPase subunit HslU, ADENOSINE-5'-DIPHOSPHATE
Authors:Grant, R.A., Chen, J., Glynn, S.E., Sauer, R.T.
Deposit date:2016-11-17
Release date:2017-03-01
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (7.086 Å)
Cite:Covalently linked HslU hexamers support a probabilistic mechanism that links ATP hydrolysis to protein unfolding and translocation.
J. Biol. Chem., 292, 2017
6AX4
  • Download 6ax4
  • View 6ax4
Molmil generated image of 6ax4
PLK-1 POLO-BOX DOMAIN IN COMPLEX WITH HISTIDINE N(TAU)-CYCLIZED MACROCYCLE 5B.
Descriptor:Serine/threonine-protein kinase PLK1, histidine N(tau)-cyclized Macrocycle 5b, AMYLAMINE
Authors:Grant, R.A., Hymel, D., Yaffe, M.B., Burke, T.R.
Deposit date:2017-09-06
Release date:2018-09-12
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Histidine N( tau )-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
1PO1
  • Download 1po1
  • View 1po1
Molmil generated image of 1po1
POLIOVIRUS (TYPE 1, MAHONEY) IN COMPLEX WITH R80633, AN INHIBITOR OF VIRAL REPLICATION
Descriptor:POLIOVIRUS TYPE 1 MAHONEY, (METHYLPYRIDAZINE PIPERIDINE BUTYLOXYPHENYL)ETHYLACETATE, MYRISTIC ACID
Authors:Hiremath, C.N., Filman, D.J., Grant, R.A., Hogle, J.M.
Deposit date:1997-01-08
Release date:1997-12-03
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Ligand-induced conformational changes in poliovirus-antiviral drug complexes.
Acta Crystallogr.,Sect.D, 53, 1997
1PO2
  • Download 1po2
  • View 1po2
Molmil generated image of 1po2
POLIOVIRUS (TYPE 1, MAHONEY) IN COMPLEX WITH R77975, AN INHIBITOR OF VIRAL REPLICATION
Descriptor:POLIOVIRUS TYPE 1 MAHONEY, (METHYLPYRIDAZINE PIPERIDINE ETHYLOXYPHENYL)ETHYLACETATE, MYRISTIC ACID
Authors:Hiremath, C.N., Filman, D.J., Grant, R.A., Hogle, J.M.
Deposit date:1997-01-08
Release date:1997-12-03
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Ligand-induced conformational changes in poliovirus-antiviral drug complexes.
Acta Crystallogr.,Sect.D, 53, 1997
1PIV
  • Download 1piv
  • View 1piv
Molmil generated image of 1piv
BINDING OF THE ANTIVIRAL DRUG WIN51711 TO THE SABIN STRAIN OF TYPE 3 POLIOVIRUS: STRUCTURAL COMPARISON WITH DRUG BINDING IN RHINOVIRUS 14
Descriptor:POLIOVIRUS TYPE 3 (SUBUNIT VP1), POLIOVIRUS TYPE 3 (SUBUNIT VP2), POLIOVIRUS TYPE 3 (SUBUNIT VP3), ...
Authors:Hiremath, C.N., Grant, R.A., Filman, D.J., Hogle, J.M.
Deposit date:1995-02-02
Release date:1995-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Binding of the antiviral drug WIN51711 to the sabin strain of type 3 poliovirus: structural comparison with drug binding in rhinovirus 14.
Acta Crystallogr.,Sect.D, 51, 1995
1G2D
  • Download 1g2d
  • View 1g2d
Molmil generated image of 1g2d
STRUCTURE OF A CYS2HIS2 ZINC FINGER/TATA BOX COMPLEX (CLONE #2)
Descriptor:5'-D(*GP*AP*CP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*AP*G)-3', 5'-D(*TP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*GP*TP*CP*C)-3', TATA BOX ZINC FINGER PROTEIN, ...
Authors:Wolfe, S.A., Grant, R.A., Elrod-Erickson, M., Pabo, C.O.
Deposit date:2000-10-18
Release date:2001-09-07
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes.
Structure, 9, 2001
1F2I
  • Download 1f2i
  • View 1f2i
Molmil generated image of 1f2i
COCRYSTAL STRUCTURE OF SELECTED ZINC FINGER DIMER BOUND TO DNA
Descriptor:5'-D(*AP*TP*GP*GP*GP*CP*GP*CP*GP*CP*CP*CP*AP*T)-3', FUSION OF N-TERMINAL 17-MER PEPTIDE EXTENSION TO ZIF12, ZINC ION
Authors:Wang, B.S., Grant, R.A., Pabo, C.O.
Deposit date:2000-05-25
Release date:2001-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Selected peptide extension contacts hydrophobic patch on neighboring zinc finger and mediates dimerization on DNA.
Nat.Struct.Biol., 8, 2001
1G2F
  • Download 1g2f
  • View 1g2f
Molmil generated image of 1g2f
STRUCTURE OF A CYS2HIS2 ZINC FINGER/TATA BOX COMPLEX (TATAZF;CLONE #6)
Descriptor:5'-D(*GP*AP*CP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*AP*G)-3', 5'-D(*TP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*GP*TP*CP*C)-3', TATA BOX ZINC FINGER PROTEIN, ...
Authors:Wolfe, S.A., Grant, R.A., Elrod-Erickson, M., Pabo, C.O.
Deposit date:2000-10-18
Release date:2001-09-07
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Beyond the "recognition code": structures of two Cys2His2 zinc finger/TATA box complexes.
Structure, 9, 2001
1LLM
  • Download 1llm
  • View 1llm
Molmil generated image of 1llm
CRYSTAL STRUCTURE OF A ZIF23-GCN4 CHIMERA BOUND TO DNA
Descriptor:5'-D(*TP*CP*CP*CP*AP*CP*GP*CP*GP*TP*GP*GP*G)-3', chimera of Zif23-GCN4, ZINC ION
Authors:Wolfe, S.A., Grant, R.A., Pabo, C.O.
Deposit date:2002-04-29
Release date:2003-09-30
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of a designed dimeric zinc finger protein bound to DNA.
Biochemistry, 42, 2003
1OU8
  • Download 1ou8
  • View 1ou8
Molmil generated image of 1ou8
STRUCTURE OF AN AAA+ PROTEASE DELIVERY PROTEIN IN COMPLEX WITH A PEPTIDE DEGRADATION TAG
Descriptor:Stringent starvation protein B homolog, synthetic ssrA peptide, MAGNESIUM ION
Authors:Levchenko, I., Grant, R.A., Wah, D.A., Sauer, R.T., Baker, T.A.
Deposit date:2003-03-24
Release date:2003-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of a delivery protein for an AAA+ protease in complex with a peptide degradation tag
Mol.Cell, 12, 2003
1OU9
  • Download 1ou9
  • View 1ou9
Molmil generated image of 1ou9
STRUCTURE OF SSPB, A AAA+ PROTEASE DELIVERY PROTEIN
Descriptor:Stringent starvation protein B homolog, CALCIUM ION
Authors:Levchenko, I., Grant, R.A., Wah, D.A., Sauer, R.T., Baker, T.A.
Deposit date:2003-03-24
Release date:2003-09-23
Last modified:2014-04-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of a delivery protein for an AAA+ protease in complex with a peptide degradation tag
Mol.Cell, 12, 2003
1OUL
  • Download 1oul
  • View 1oul
Molmil generated image of 1oul
STRUCTURE OF THE AAA+ PROTEASE DELIVERY PROTEIN SSPB
Descriptor:Stringent starvation protein B homolog
Authors:Levchenko, I., Grant, R.A., Wah, D.A., Sauer, R.T., Baker, T.A.
Deposit date:2003-03-24
Release date:2003-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of a delivery protein for an AAA+ protease in complex with a peptide degradation tag
Mol.Cell, 12, 2003
1TWB
  • Download 1twb
  • View 1twb
Molmil generated image of 1twb
SSPB DISULFIDE CROSSLINKED TO AN SSRA DEGRADATION TAG
Descriptor:Stringent starvation protein B homolog, ssrA peptide
Authors:Bolon, D.N., Grant, R.A., Baker, T.A., Sauer, R.T.
Deposit date:2004-06-30
Release date:2004-11-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nucleotide-Dependent Substrate Handoff from the SspB Adaptor to the AAA+ ClpXP Protease.
Mol.Cell, 16, 2004
1U9P
  • Download 1u9p
  • View 1u9p
Molmil generated image of 1u9p
PERMUTED SINGLE-CHAIN ARC
Descriptor:pArc
Authors:Tabtiang, R.K., Cezairliyan, B.O., Grant, R.A., Cochrane, J.C., Sauer, R.T.
Deposit date:2004-08-10
Release date:2005-02-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Consolidating critical binding determinants by noncyclic rearrangement of protein secondary structure
Proc.Natl.Acad.Sci.Usa, 102, 2005