Author results

4INR
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YEAST 20S PROTEASOME IN COMPLEX WITH THE VINYL SULFONE LU102
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Geurink, P.P., van der Linden, W.A., Mirabella, A.C., Gallastegui, N., de Bruin, G., Blom, A.E.M., Voges, M.J., Mock, E.D., Florea, B.I., van der Marel, G.A., Driessen, C., van der Stelt, M., Groll, M., Overkleeft, H.S., Kisselev, A.F.
Deposit date:2013-01-06
Release date:2013-01-30
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites.
J.Med.Chem., 56, 2013
4INT
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YEAST 20S PROTEASOME IN COMPLEX WITH THE VINYL SULFONE LU122
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Geurink, P.P., van der Linden, W.A., Mirabella, A.C., Gallastegui, N., de Bruin, G., Blom, A.E.M., Voges, M.J., Mock, E.D., Florea, B.I., van der Marel, G.A., Driessen, C., van der Stelt, M., Groll, M., Overkleeft, H.S., Kisselev, A.F.
Deposit date:2013-01-06
Release date:2013-01-30
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites.
J.Med.Chem., 56, 2013
4INU
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YEAST 20S PROTEASOME IN COMPLEX WITH THE VINYL SULFONE LU112
Descriptor:Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ...
Authors:Geurink, P.P., van der Linden, W.A., Mirabella, A.C., Gallastegui, N., de Bruin, G., Blom, A.E.M., Voges, M.J., Mock, E.D., Florea, B.I., van der Marel, G.A., Driessen, C., van der Stelt, M., Groll, M., Overkleeft, H.S., Kisselev, A.F.
Deposit date:2013-01-06
Release date:2013-01-30
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites.
J.Med.Chem., 56, 2013
4BOP
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STRUCTURE OF OTUD1 OTU DOMAIN
Descriptor:OTU DOMAIN-CONTAINING PROTEIN 1, PHOSPHATE ION
Authors:Mevissen, T.E.T., Hospenthal, M.K., Geurink, P.P., Elliott, P.R., Akutsu, M., Arnaudo, N., Ekkebus, R., Kulathu, Y., Wauer, T., El Oualid, F., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2013-05-22
Release date:2013-07-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Otu Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis.
Cell(Cambridge,Mass.), 154, 2013
4BOQ
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STRUCTURE OF OTUD2 OTU DOMAIN
Descriptor:UBIQUITIN THIOESTERASE OTU1, GLYCEROL
Authors:Mevissen, T.E.T., Hospenthal, M.K., Geurink, P.P., Elliott, P.R., Akutsu, M., Arnaudo, N., Ekkebus, R., Kulathu, Y., Wauer, T., El Oualid, F., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2013-05-22
Release date:2013-07-17
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Otu Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis.
Cell(Cambridge,Mass.), 154, 2013
4BOS
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STRUCTURE OF OTUD2 OTU DOMAIN IN COMPLEX WITH UBIQUITIN K11-LINKED PEPTIDE
Descriptor:UBIQUITIN THIOESTERASE OTU1, POLYUBIQUITIN-C, OTUD2, ...
Authors:Mevissen, T.E.T., Hospenthal, M.K., Geurink, P.P., Elliott, P.R., Akutsu, M., Arnaudo, N., Ekkebus, R., Kulathu, Y., Wauer, T., El Oualid, F., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2013-05-22
Release date:2013-07-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Otu Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis.
Cell(Cambridge,Mass.), 154, 2013
4BOU
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STRUCTURE OF OTUD3 OTU DOMAIN
Descriptor:OTU DOMAIN-CONTAINING PROTEIN 3
Authors:Mevissen, T.E.T., Hospenthal, M.K., Geurink, P.P., Elliott, P.R., Akutsu, M., Arnaudo, N., Ekkebus, R., Kulathu, Y., Wauer, T., El Oualid, F., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2013-05-22
Release date:2013-07-17
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Otu Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis.
Cell(Cambridge,Mass.), 154, 2013
4BOZ
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STRUCTURE OF OTUD2 OTU DOMAIN IN COMPLEX WITH K11-LINKED DI UBIQUITIN
Descriptor:UBIQUITIN THIOESTERASE OTU1, UBIQUITIN-C, GLYCEROL
Authors:Mevissen, T.E.T., Hospenthal, M.K., Geurink, P.P., Elliott, P.R., Akutsu, M., Arnaudo, N., Ekkebus, R., Kulathu, Y., Wauer, T., El Oualid, F., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2013-05-22
Release date:2013-07-17
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Otu Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis.
Cell(Cambridge,Mass.), 154, 2013
5LRU
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STRUCTURE OF CEZANNE/OTUD7B OTU DOMAIN
Descriptor:OTU domain-containing protein 7B
Authors:Mevissen, T.E.T., Kulathu, Y., Mulder, M.P.C., Geurink, P.P., Maslen, S.L., Gersch, M., Elliott, P.R., Burke, J.E., van Tol, B.D.M., Akutsu, M., El Oualid, F., Kawasaki, M., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRV
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STRUCTURE OF CEZANNE/OTUD7B OTU DOMAIN BOUND TO LYS11-LINKED DIUBIQUITIN
Descriptor:OTU domain-containing protein 7B, Polyubiquitin-B, PHOSPHATE ION, ...
Authors:Mevissen, T.E.T., Kulathu, Y., Mulder, M.P.C., Geurink, P.P., Maslen, S.L., Gersch, M., Elliott, P.R., Burke, J.E., van Tol, B.D.M., Akutsu, M., El Oualid, F., Kawasaki, M., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRW
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STRUCTURE OF CEZANNE/OTUD7B OTU DOMAIN BOUND TO UBIQUITIN
Descriptor:OTU domain-containing protein 7B, Polyubiquitin-B, GLYCEROL
Authors:Mevissen, T.E.T., Kulathu, Y., Mulder, M.P.C., Geurink, P.P., Maslen, S.L., Gersch, M., Elliott, P.R., Burke, J.E., van Tol, B.D.M., Akutsu, M., El Oualid, F., Kawasaki, M., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRX
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STRUCTURE OF A20 OTU DOMAIN BOUND TO UBIQUITIN
Descriptor:Tumor necrosis factor alpha-induced protein 3, Polyubiquitin-B
Authors:Mevissen, T.E.T., Kulathu, Y., Mulder, M.P.C., Geurink, P.P., Maslen, S.L., Gersch, M., Elliott, P.R., Burke, J.E., van Tol, B.D.M., Akutsu, M., El Oualid, F., Kawasaki, M., Freund, S.M.V., Ovaa, H., Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
3ZNH
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CRIMEAN CONGO HEMORRHAGIC FEVER VIRUS OTU DOMAIN IN COMPLEX WITH UBIQUITIN-PROPARGYL.
Descriptor:UBIQUITIN THIOESTERASE, POLYUBIQUITIN-B
Authors:Ekkebus, R., vanKasteren, S.I., Kulathu, Y., Scholten, A., Berlin, I., deJong, A., Goerdayal, G., Neefjes, J., Heck, A.J.R., Komander, D., Ovaa, H.
Deposit date:2013-02-14
Release date:2013-02-27
Last modified:2013-03-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:On Terminal Alkynes that Can React with Active-Site Cysteine Nucleophiles in Proteases.
J.Am.Chem.Soc., 135, 2013
5CHT
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CRYSTAL STRUCTURE OF USP18
Descriptor:Ubl carboxyl-terminal hydrolase 18, ZINC ION
Authors:Fritz, G., Basters, A.
Deposit date:2015-07-10
Release date:2016-06-29
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of the specificity of USP18 toward ISG15.
Nat. Struct. Mol. Biol., 24, 2017
5CHV
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CRYSTAL STRUCTURE OF USP18-ISG15 COMPLEX
Descriptor:Ubl carboxyl-terminal hydrolase 18, Ubiquitin-like protein ISG15, ZINC ION, ...
Authors:Fritz, G., Basters, A.
Deposit date:2015-07-10
Release date:2016-09-28
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (3.005 Å)
Cite:Structural basis of the specificity of USP18 toward ISG15.
Nat. Struct. Mol. Biol., 24, 2017
5HAF
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STRUCTURE OF SALMONELLA ENTERICA EFFECTOR PROTEIN SSEL
Descriptor:Deubiquitinase SseL, POTASSIUM ION
Authors:Pruneda, J.N., Komander, D.
Deposit date:2015-12-30
Release date:2016-07-27
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.
Mol.Cell, 63, 2016
5HAG
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STRUCTURE OF CHLAMYDIA TRACHOMATIS EFFECTOR PROTEIN CHLADUB1
Descriptor:Deubiquitinase and deneddylase Dub1, GLYCEROL
Authors:Pruneda, J.N., Komander, D.
Deposit date:2015-12-30
Release date:2016-07-27
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.
Mol.Cell, 63, 2016
5HAM
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STRUCTURE OF RICKETTSIA BELLII EFFECTOR PROTEIN RICKCE
Descriptor:RickCE
Authors:Pruneda, J.N., Komander, D.
Deposit date:2015-12-30
Release date:2016-07-27
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.
Mol.Cell, 63, 2016
5JP1
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STRUCTURE OF XANTHOMONAS CAMPESTRIS EFFECTOR PROTEIN XOPD BOUND TO TOMATO SUMO
Descriptor:Xanthomonas outer protein D, Small ubiquitin-related modifier, MALONATE ION, ...
Authors:Pruneda, J.N., Komander, D.
Deposit date:2016-05-03
Release date:2016-07-27
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.
Mol.Cell, 63, 2016
5JP3
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STRUCTURE OF XANTHOMONAS CAMPESTRIS EFFECTOR PROTEIN XOPD BOUND TO UBIQUITIN
Descriptor:Xanthomonas outer protein D, Polyubiquitin-B
Authors:Pruneda, J.N., Komander, D.
Deposit date:2016-05-03
Release date:2016-07-27
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.
Mol.Cell, 63, 2016
5NCX
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CRYSTAL STRUCTURE OF THERMOANAEROBACTERIUM XYLOLYTICUM GH116 BETA-GLUCOSIDASE WITH AN COVALENT INHIBITOR
Descriptor:Glucosylceramidase, ~{N}-[(1~{R},2~{R},3~{R},4~{S},5~{S},6~{S})-2-(hydroxymethyl)-3,4,5,6-tetrakis(oxidanyl)cyclohexyl]pentanamide, CALCIUM ION, ...
Authors:Davies, G.J., Breen, I.Z.
Deposit date:2017-03-06
Release date:2017-10-04
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase.
J. Am. Chem. Soc., 139, 2017
6FFA
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FMDV LEADER PROTEASE BOUND TO SUBSTRATE ISG15
Descriptor:Lbpro, Ubiquitin-like protein ISG15, GLYCEROL, ...
Authors:Swatek, K.N., Pruneda, J.N., Komander, D.
Deposit date:2018-01-05
Release date:2018-02-21
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018