8CMS

OTUB2 in covalent complex with LN5P45

This is a non-PDB format compatible entry.

Summary for 8CMS

• Entry DOI: 10.2210/pdb8cms/pdb
• Descriptor: Ubiquitin thioesterase OTUB2, (1~{S},2~{S})-~{N}'-ethanoyl-2-(3-methylphenyl)cyclopropane-1-carbohydrazide (3 entities in total)
• Functional Keywords: chemical modification, ubiquitin, deubiquitinase, inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 27637.37

Authors

Gan, J.,de Vries, J. (deposition date: 2023-02-21, release date: 2023-11-15)

• Primary citation: Gan, J.,de Vries, J.,Akkermans, J.J.L.L.,Mohammed, Y.,Tjokrodirijo, R.T.N.,de Ru, A.H.,Kim, R.Q.,Vargas, D.A.,Pol, V.,Fasan, R.,van Veelen, P.A.,Neefjes, J.,van Dam, H.,Ovaa, H.,Sapmaz, A.,Geurink, P.P.; Cellular Validation of a Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2.; Acs Chem.Biol., 18:2003-2013, 2023; PubMed: 37642399; DOI: 10.1021/acschembio.3c00227

Experimental method

X-RAY DIFFRACTION (1.77 Å)