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4WUY
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BU of 4wuy by Molmil
Crystal Structure of Protein Lysine Methyltransferase SMYD2 in complex with LLY-507, a Cell-Active, Potent and Selective Inhibitor
Descriptor: 5-cyano-2'-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl}-N-[3-(pyrrolidin-1-yl)propyl]biphenyl-3-carboxamide, GLYCEROL, N-lysine methyltransferase SMYD2, ...
Authors:Nguyen, H, Allali-Hassani, A, Antonysamy, S, Chang, S, Chen, L.H, Curtis, C, Emtage, S, Fan, L, Gheyi, T, Li, F, Liu, S, Martin, J.R, Mendel, D, Olsen, J.B, Pelletier, L, Shatseva, T, Wu, S, Zhang, F.F, Arrowsmith, C.H, Brown, P.J, Campbell, R.M, Garcia, B.A, Barsyte-Lovejoy, D, Mader, M, Vedadi, M.
Deposit date:2014-11-04
Release date:2015-04-08
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2.
J.Biol.Chem., 290, 2015
6XKV
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BU of 6xkv by Molmil
R. capsulatus cyt bc1 with both FeS proteins in b position (CIII2 b-b)
Descriptor: Cytochrome b, Cytochrome c1, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Steimle, S, Van Eeuwen, T, Ozturk, Y, Kim, H.J, Braitbard, M, Selamoglu, N, Garcia, B.A, Schneidman-Duhovny, D, Murakami, K, Daldal, F.
Deposit date:2020-06-27
Release date:2020-12-30
Last modified:2021-07-14
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structures of engineered active bc 1 -cbb 3 type CIII 2 CIV super-complexes and electronic communication between the complexes.
Nat Commun, 12, 2021
6XKT
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BU of 6xkt by Molmil
R. capsulatus cyt bc1 with both FeS proteins in c position (CIII2 c-c)
Descriptor: Cytochrome b, Cytochrome c1, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Steimle, S, Van Eeuwen, T, Ozturk, Y, Kim, H.J, Braitbard, M, Selamoglu, N, Garcia, B.A, Schneidman-Duhovny, D, Murakami, K, Daldal, F.
Deposit date:2020-06-27
Release date:2020-12-30
Last modified:2021-03-03
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:Cryo-EM structures of engineered active bc 1 -cbb 3 type CIII 2 CIV super-complexes and electronic communication between the complexes.
Nat Commun, 12, 2021
6XI0
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BU of 6xi0 by Molmil
R. capsulatus cyt bc1 (CIII2) at 3.3A
Descriptor: Cytochrome b, Cytochrome c1, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Steimle, S, Van Eeuwen, T, Ozturk, Y, Kim, H.J, Braitbard, M, Selamoglu, N, Garcia, B.A, Schneidman-Duhovny, D, Murakami, K, Daldal, F.
Deposit date:2020-06-19
Release date:2020-12-30
Last modified:2021-03-03
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structures of engineered active bc 1 -cbb 3 type CIII 2 CIV super-complexes and electronic communication between the complexes.
Nat Commun, 12, 2021
6XKW
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BU of 6xkw by Molmil
R. capsulatus CIII2CIV bipartite super-complex (SC-2A) with CcoH/cy
Descriptor: COPPER (II) ION, Cbb3-type cytochrome c oxidase subunit CcoP, Cytochrome b, ...
Authors:Steimle, S, Van Eeuwen, T, Ozturk, Y, Kim, H.J, Braitbard, M, Selamoglu, N, Garcia, B.A, Schneidman-Duhovny, D, Murakami, K, Daldal, F.
Deposit date:2020-06-27
Release date:2020-12-30
Last modified:2021-03-03
Method:ELECTRON MICROSCOPY (5.2 Å)
Cite:Cryo-EM structures of engineered active bc 1 -cbb 3 type CIII 2 CIV super-complexes and electronic communication between the complexes.
Nat Commun, 12, 2021
6XKX
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BU of 6xkx by Molmil
R. capsulatus CIII2CIV tripartite super-complex, conformation A (SC-1A)
Descriptor: COPPER (II) ION, Cbb3-type cytochrome c oxidase subunit CcoP,Cytochrome c-type cyt cy, Cytochrome b, ...
Authors:Steimle, S, Van Eeuwen, T, Ozturk, Y, Kim, H.J, Braitbard, M, Selamoglu, N, Garcia, B.A, Schneidman-Duhovny, D, Murakami, K, Daldal, F.
Deposit date:2020-06-27
Release date:2020-12-30
Last modified:2021-03-03
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Cryo-EM structures of engineered active bc 1 -cbb 3 type CIII 2 CIV super-complexes and electronic communication between the complexes.
Nat Commun, 12, 2021
6XKU
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BU of 6xku by Molmil
R. capsulatus cyt bc1 with one FeS protein in b position and one in c position (CIII2 b-c)
Descriptor: Cytochrome b, Cytochrome c1, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Steimle, S, Van Eeuwen, T, Ozturk, Y, Kim, H.J, Braitbard, M, Selamoglu, N, Garcia, B.A, Schneidman-Duhovny, D, Murakami, K, Daldal, F.
Deposit date:2020-06-27
Release date:2020-12-30
Last modified:2021-03-03
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Cryo-EM structures of engineered active bc 1 -cbb 3 type CIII 2 CIV super-complexes and electronic communication between the complexes.
Nat Commun, 12, 2021
6XKZ
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BU of 6xkz by Molmil
R. capsulatus CIII2CIV tripartite super-complex, conformation B (SC-1B)
Descriptor: COPPER (II) ION, Cbb3-type cytochrome c oxidase subunit CcoP,Cytochrome c-type cyt cy, Cytochrome b, ...
Authors:Steimle, S, Van Eeuwen, T, Ozturk, Y, Kim, H.J, Braitbard, M, Selamoglu, N, Garcia, B.A, Schneidman-Duhovny, D, Murakami, K, Daldal, F.
Deposit date:2020-06-27
Release date:2020-12-30
Last modified:2021-03-03
Method:ELECTRON MICROSCOPY (7.2 Å)
Cite:Cryo-EM structures of engineered active bc 1 -cbb 3 type CIII 2 CIV super-complexes and electronic communication between the complexes.
Nat Commun, 12, 2021
7KPX
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BU of 7kpx by Molmil
Structure of the yeast CKM
Descriptor: Mediator of RNA polymerase II transcription subunit 12, Mediator of RNA polymerase II transcription subunit 13, Meiotic mRNA stability protein kinase SSN3, ...
Authors:Li, Y.C, Chao, T.C, Kim, H.J, Cholko, T, Chen, S.F, Nakanishi, K, Chang, C.E, Murakami, K, Garcia, B.A, Boyer, T.G, Tsai, K.L.
Deposit date:2020-11-12
Release date:2021-01-27
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module.
Sci Adv, 7, 2021
7KPV
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BU of 7kpv by Molmil
Structure of kinase and Central lobes of yeast CKM
Descriptor: Mediator of RNA polymerase II transcription subunit 12, Mediator of RNA polymerase II transcription subunit 13, Meiotic mRNA stability protein kinase SSN3, ...
Authors:Li, Y.C, Chao, T.C, Kim, H.J, Cholko, T, Chen, S.F, Nakanishi, K, Chang, C.E, Murakami, K, Garcia, B.A, Boyer, T.G, Tsai, K.L.
Deposit date:2020-11-12
Release date:2021-01-27
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module.
Sci Adv, 7, 2021
7ML0
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BU of 7ml0 by Molmil
RNA polymerase II pre-initiation complex (PIC1)
Descriptor: BJ4_G0050160.mRNA.1.CDS.1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB3, ...
Authors:Yang, C, Fujiwara, R, Kim, H.J, Gorbea Colon, J.J, Steimle, S, Garcia, B.A, Murakami, K.
Deposit date:2021-04-27
Release date:2022-02-02
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II.
Mol.Cell, 82, 2022
7ML1
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BU of 7ml1 by Molmil
RNA polymerase II pre-initiation complex (PIC2)
Descriptor: BJ4_G0050160.mRNA.1.CDS.1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB3, ...
Authors:Yang, C, Fujiwara, R, Kim, H.J, Gorbea Colon, J.J, Steimle, S, Garcia, B.A, Murakami, K.
Deposit date:2021-04-27
Release date:2022-02-02
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II.
Mol.Cell, 82, 2022
7ML4
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BU of 7ml4 by Molmil
RNA polymerase II initially transcribing complex (ITC)
Descriptor: BJ4_G0050160.mRNA.1.CDS.1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB3, ...
Authors:Yang, C, Fujiwara, R, Kim, H.J, Gorbea Colon, J.J, Steimle, S, Garcia, B.A, Murakami, K.
Deposit date:2021-04-27
Release date:2022-02-02
Last modified:2022-03-09
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II.
Mol.Cell, 82, 2022
7ML3
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BU of 7ml3 by Molmil
General transcription factor TFIIH (weak binding)
Descriptor: BJ4_G0050160.mRNA.1.CDS.1, General transcription and DNA repair factor IIH, General transcription and DNA repair factor IIH helicase subunit XPB, ...
Authors:Yang, C, Fujiwara, R, Kim, H.J, Gorbea Colon, J.J, Steimle, S, Garcia, B.A, Murakami, K.
Deposit date:2021-04-27
Release date:2022-02-02
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (7.6 Å)
Cite:Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II.
Mol.Cell, 82, 2022
7ML2
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BU of 7ml2 by Molmil
RNA polymerase II pre-initiation complex (PIC3)
Descriptor: BJ4_G0004860.mRNA.1.CDS.1, BJ4_G0050160.mRNA.1.CDS.1, DNA-directed RNA polymerase II subunit RPB11, ...
Authors:Yang, C, Fujiwara, R, Kim, H.J, Gorbea Colon, J.J, Steimle, S, Garcia, B.A, Murakami, K.
Deposit date:2021-04-27
Release date:2022-02-02
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II.
Mol.Cell, 82, 2022
7KPW
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BU of 7kpw by Molmil
Structure of the H-lobe of yeast CKM
Descriptor: Mediator of RNA polymerase II transcription subunit 12
Authors:Li, Y.C, Chao, T.C, Kim, H.J, Cholko, T, Chen, S.F, Nakanishi, K, Chang, C.E, Murakami, K, Garcia, B.A, Boyer, T.G, Tsai, K.L.
Deposit date:2020-11-12
Release date:2021-01-27
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module.
Sci Adv, 7, 2021
6J9J
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BU of 6j9j by Molmil
crystal structure of SESTD2 in complex with H3.3S31phK36M peptide
Descriptor: H3.3S31phK36M(29-42), Histone-lysine N-methyltransferase SETD2, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Yang, S, Li, H.T.
Deposit date:2019-01-23
Release date:2020-02-26
Last modified:2020-08-12
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Histone H3.3 phosphorylation amplifies stimulation-induced transcription.
Nature, 583, 2020
8GHL
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BU of 8ghl by Molmil
the Hir complex core
Descriptor: Histone transcription regulator 3, Protein HIR1, Protein HIR2
Authors:Kim, H.J, Murakami, K.
Deposit date:2023-03-10
Release date:2024-07-17
Last modified:2024-08-07
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Structure of the Hir histone chaperone complex.
Mol.Cell, 84, 2024
8GHN
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BU of 8ghn by Molmil
Composite model of the yeast Hir Complex with Asf1/H3/H4
Descriptor: Histone H3, Histone H4, Histone chaperone, ...
Authors:Kim, H.J, Murakami, K.
Deposit date:2023-03-10
Release date:2024-07-17
Last modified:2024-08-07
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Structure of the Hir histone chaperone complex.
Mol.Cell, 84, 2024
8GHA
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BU of 8gha by Molmil
Hir3 Arm/Tail, Hir2 WD40, C-terminal Hpc2
Descriptor: Histone promoter control protein 2, Histone transcription regulator 3, Protein HIR2
Authors:Kim, H.J, Murakami, K.
Deposit date:2023-03-09
Release date:2024-07-10
Last modified:2024-08-07
Method:ELECTRON MICROSCOPY (6.8 Å)
Cite:Structure of the Hir histone chaperone complex.
Mol.Cell, 84, 2024
8GHM
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BU of 8ghm by Molmil
Hir1 WD40 domains and Asf1/H3/H4
Descriptor: Histone H3, Histone H4, Histone chaperone, ...
Authors:Kim, H.J, Murakami, K.
Deposit date:2023-03-10
Release date:2024-07-10
Last modified:2024-08-07
Method:ELECTRON MICROSCOPY (12 Å)
Cite:Structure of the Hir histone chaperone complex.
Mol.Cell, 84, 2024
8GIX
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BU of 8gix by Molmil
Chaetomium thermophilum Hir3
Descriptor: 3,3',3''-phosphanetriyltripropanoic acid, Histone transcription regulator 3 homolog
Authors:Szurgot, M.R, van Eeuwen, T, Kim, H.J, Marmorstein, R.
Deposit date:2023-03-14
Release date:2024-07-10
Last modified:2024-08-07
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure of the Hir histone chaperone complex.
Mol.Cell, 84, 2024
8SB6
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BU of 8sb6 by Molmil
Structure of human BRD2-BD1 bound to a histone H4 acetyl-methyllysine peptide
Descriptor: Bromodomain containing 2, Histone H4
Authors:Connor, L.J, Ekundayo, B.E, Lu-Culligan, W.J, Simon, M.D, Bleichert, F.
Deposit date:2023-04-02
Release date:2023-07-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Acetyl-methyllysine marks chromatin at active transcription start sites.
Nature, 622, 2023
6OIE
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BU of 6oie by Molmil
The double PHD finger (DPF) of MORF in complex with histone H3K14cr
Descriptor: Histone H3.1t peptide, Histone acetyltransferase KAT6B, ZINC ION
Authors:Klein, B.J, Kutateladze, T.G.
Deposit date:2019-04-09
Release date:2019-11-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.075 Å)
Cite:Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation.
Nat Commun, 10, 2019
7MEI
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BU of 7mei by Molmil
Composite structure of EC+EC
Descriptor: DNA (74-MER), DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB3, ...
Authors:Yang, C, Murakami, K.
Deposit date:2021-04-06
Release date:2022-03-02
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II.
Mol.Cell, 82, 2022

 

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