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4I43
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BU of 4i43 by Molmil
Crystal structure of Prp8:Aar2 complex
Descriptor: A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8
Authors:Galej, W.P, Oubridge, C, Newman, A.J, Nagai, K.
Deposit date:2012-11-27
Release date:2013-01-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of Prp8 reveals active site cavity of the spliceosome.
Nature, 493, 2013
3ZEF
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BU of 3zef by Molmil
Crystal structure of Prp8:Aar2 complex: second crystal form at 3.1 Angstrom resolution
Descriptor: A1 CISTRON-SPLICING FACTOR AAR2, PRE-MRNA-SPLICING FACTOR 8
Authors:Galej, W.P, Oubridge, C, Newman, A.J, Nagai, K.
Deposit date:2012-12-05
Release date:2013-01-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal Structure of Prp8 Reveals Active Site Cavity of the Spliceosome
Nature, 493, 2013
5LJ3
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BU of 5lj3 by Molmil
Structure of the core of the yeast spliceosome immediately after branching
Descriptor: CEF1, CLF1, CWC15, ...
Authors:Galej, W.P, Wilkinson, M.F, Fica, S.M, Oubridge, C, Newman, A.J, Nagai, K.
Deposit date:2016-07-17
Release date:2016-08-03
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structure of the spliceosome immediately after branching.
Nature, 537, 2016
5LJ5
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BU of 5lj5 by Molmil
Overall structure of the yeast spliceosome immediately after branching.
Descriptor: CWC15, CWC22, Exon 1 (5' exon) of UBC4 pre-mRNA, ...
Authors:Galej, W.P, Wilkinson, M.F, Fica, S.M, Oubridge, C, Newman, A.J, Nagai, K.
Deposit date:2016-07-17
Release date:2016-08-31
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structure of the spliceosome immediately after branching.
Nature, 537, 2016
5MPS
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BU of 5mps by Molmil
Structure of a spliceosome remodeled for exon ligation
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ...
Authors:Fica, S.M, Oubridge, C, Galej, W.P, Wilkinson, M.E, Newman, A.J, Bai, X.-C, Nagai, K.
Deposit date:2016-12-18
Release date:2017-01-18
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (3.85 Å)
Cite:Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017
5MQ0
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BU of 5mq0 by Molmil
Structure of a spliceosome remodeled for exon ligation
Descriptor: 3'-EXON OF UBC4 PRE-MRNA, BOUND BY PRP22 HELICASE, 5'-EXON OF UBC4 PRE-MRNA, ...
Authors:Fica, S.M, Oubridge, C, Galej, W.P, Wilkinson, M.E, Newman, A.J, Bai, X.-C, Nagai, K.
Deposit date:2016-12-19
Release date:2017-01-18
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (4.17 Å)
Cite:Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017
6S5T
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BU of 6s5t by Molmil
Legionella pneumophila SidJ-Human calmodulin complex
Descriptor: Calmodulin-2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SidJ
Authors:Bhogaraju, S, Galej, W.P, Pfleiderer, M.M, Adams, M.
Deposit date:2019-07-02
Release date:2019-07-24
Last modified:2019-08-28
Method:ELECTRON MICROSCOPY (4.15 Å)
Cite:Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylation.
Nature, 572, 2019
5GAO
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BU of 5gao by Molmil
Head region of the yeast spliceosomal U4/U6.U5 tri-snRNP
Descriptor: Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2, Saccharomyces cerevisiae strain UOA_M2 chromosome 5 sequence, ...
Authors:Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
5GAM
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BU of 5gam by Molmil
Foot region of the yeast spliceosomal U4/U6.U5 tri-snRNP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, ...
Authors:Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K.
Deposit date:2015-12-15
Release date:2016-02-03
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Angstrom resolution
Nature, 530, 2016
5GAN
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BU of 5gan by Molmil
The overall structure of the yeast spliceosomal U4/U6.U5 tri-snRNP at 3.7 Angstrom
Descriptor: 13 kDa ribonucleoprotein-associated protein, GUANOSINE-5'-TRIPHOSPHATE, Pre-mRNA-processing factor 31, ...
Authors:Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
6EXN
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BU of 6exn by Molmil
Post-catalytic P complex spliceosome with 3' splice site docked
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, Intron lariat: UBC4 RNA, ...
Authors:Wilkinson, M.E, Fica, S.M, Galej, W.P, Norman, C.M, Newman, A.J, Nagai, K.
Deposit date:2017-11-08
Release date:2018-01-17
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection.
Science, 358, 2017
7Q4P
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BU of 7q4p by Molmil
U2 snRNP after ATP-dependent remodelling
Descriptor: PHD finger-like domain-containing protein 5A, Splicing factor 3A subunit 2, Splicing factor 3A subunit 3, ...
Authors:Tholen, J, Galej, W.P.
Deposit date:2021-11-01
Release date:2022-03-30
Last modified:2022-04-06
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Structural basis of branch site recognition by the human spliceosome.
Science, 375, 2022
7Q3L
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BU of 7q3l by Molmil
Human 17S U2 snRNP 5' domain
Descriptor: HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, Probable ATP-dependent RNA helicase DDX46, ...
Authors:Tholen, J, Galej, W.P.
Deposit date:2021-10-28
Release date:2022-03-30
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Structural basis of branch site recognition by the human spliceosome.
Science, 375, 2022
7Q4O
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BU of 7q4o by Molmil
Substrate-bound A-like U2 snRNP
Descriptor: BPS oligo, PHD finger-like domain-containing protein 5A, Splicing factor 3A subunit 2, ...
Authors:Tholen, J, Galej, W.P.
Deposit date:2021-11-01
Release date:2022-03-30
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Structural basis of branch site recognition by the human spliceosome.
Science, 375, 2022
8Q4L
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BU of 8q4l by Molmil
GBP1 bound by 14-3-3sigma
Descriptor: 14-3-3 protein sigma, Guanylate-binding protein 1
Authors:Pfleiderer, M.M, Liu, X, Fisch, D, Anastasakou, E, Frickel, E.M, Galej, W.P.
Deposit date:2023-08-07
Release date:2023-10-11
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (5.12 Å)
Cite:PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection.
Science, 382, 2023
5GAP
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BU of 5gap by Molmil
Body region of the U4/U6.U5 tri-snRNP
Descriptor: 13 kDa ribonucleoprotein-associated protein, Pre-mRNA-processing factor 31, Pre-mRNA-splicing factor 6, ...
Authors:Nguyen, T.H.D, Galej, W.P, Oubridge, C, Bai, X.C, Newman, A, Scheres, S, Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
7B9V
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BU of 7b9v by Molmil
Yeast C complex spliceosome at 2.8 Angstrom resolution with Prp18/Slu7 bound
Descriptor: 5' exon of UBC4 mRNA, BJ4_G0027490.mRNA.1.CDS.1, BJ4_G0054360.mRNA.1.CDS.1, ...
Authors:Wilkinson, M.E, Fica, S.M, Galej, W.P, Nagai, K.
Deposit date:2020-12-14
Release date:2021-03-10
Last modified:2021-04-14
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for conformational equilibrium of the catalytic spliceosome.
Mol.Cell, 81, 2021
7BFP
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BU of 7bfp by Molmil
Structure of the Integrator cleavage module with INTS4/9/11
Descriptor: Integrator complex subunit 11, Integrator complex subunit 4, Integrator complex subunit 9, ...
Authors:Pfleiderer, M.M, Galej, W.P.
Deposit date:2021-01-04
Release date:2021-03-24
Last modified:2021-03-31
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the catalytic core of the Integrator complex.
Mol.Cell, 81, 2021
7BFQ
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BU of 7bfq by Molmil
Structure of the Integrator cleavage module with extended INTS4 and rigid body docked INTS9/11 CTD
Descriptor: Integrator complex subunit 11, Integrator complex subunit 4, Integrator complex subunit 9, ...
Authors:Pfleiderer, M.M, Galej, W.P.
Deposit date:2021-01-04
Release date:2021-03-24
Last modified:2021-03-31
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the catalytic core of the Integrator complex.
Mol.Cell, 81, 2021
4BGD
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BU of 4bgd by Molmil
Crystal structure of Brr2 in complex with the Jab1/MPN domain of Prp8
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Nguyen, T.H.D, Li, J, Nagai, K.
Deposit date:2013-03-25
Release date:2013-05-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis of Brr2-Prp8 Interactions and Implications for U5 Snrnp Biogenesis and the Spliceosome Active Site
Structure, 21, 2013

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