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5DW1
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X-RAY CRYSTAL STRUCTURE OF HUMAN BRD2(BD2) IN COMPLEX WITH RVX297 TO 1.55 A RESOLUTION
Descriptor:Bromodomain-containing protein 2, 2-{3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,7-dimethoxyquinazolin-4(3H)-one, SODIUM ION
Authors:White, A., Fontano, E., Suto, R.K.
Deposit date:2015-09-22
Release date:2016-06-22
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:RVX-297- a novel BD2 selective inhibitor of BET bromodomains.
Biochem.Biophys.Res.Commun., 477, 2016
5DW2
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X-RAY CRYSTAL STRUCTURE OF HUMAN BRD4(BD1) IN COMPLEX WITH RVX297 TO 1.12 A RESOLUTION
Descriptor:Bromodomain-containing protein 4, 2-{3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,7-dimethoxyquinazolin-4(3H)-one, 1,2-ETHANEDIOL
Authors:White, A., Fontano, E., Suto, R.K.
Deposit date:2015-09-22
Release date:2016-06-22
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:RVX-297- a novel BD2 selective inhibitor of BET bromodomains.
Biochem.Biophys.Res.Commun., 477, 2016
3INM
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NADP(+)-DEPENDENT ISOCITRATE DEHYDROGENASE R132H MUTANT IN COMPLEX WITH NADPH, ALPHA-KETOGLUTARATE AND CALCIUM(2+)
Descriptor:Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-OXOGLUTARIC ACID, ...
Authors:Fontano, E., Brown, R.S., Suto, R.K., Bhyravbhatla, B.
Deposit date:2009-08-12
Release date:2009-11-24
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Nature, 462, 2009
6E4A
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CRYSTAL STRUCTURE OF HUMAN BRD4(1) IN COMPLEX WITH CN750
Descriptor:Bromodomain-containing protein 4, 5-(4-{[(3-chlorophenyl)methyl]amino}-2-{4-[2-(dimethylamino)ethyl]piperazin-1-yl}quinazolin-6-yl)-1-methylpyridin-2(1H)-one, GLYCEROL
Authors:Fontano, E., White, A., Lakshminarasimhan, D., Suto, R.K.
Deposit date:2018-07-17
Release date:2018-09-12
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Discovery and lead identification of quinazoline-based BRD4 inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
4J1P
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X-RAY CRYSTAL STRUCTURE OF BROMODOMAIN 2 OF HUMAN BRD2 IN COMPLEX WITH RVX208 TO 1.08 A RESOLUTION
Descriptor:Bromodomain containing 2, isoform CRA_a, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one, ...
Authors:Stein, A.J., White, A., Suto, R.K.
Deposit date:2013-02-01
Release date:2014-01-15
Method:X-RAY DIFFRACTION (1.08 Å)
Cite:RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist.
Plos One, 8, 2013
4J3I
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X-RAY CRYSTAL STRUCTURE OF BROMODOMAIN COMPLEX TO 1.24 A RESOLUTION
Descriptor:Bromodomain-containing protein 4, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one, 1,2-ETHANEDIOL, ...
Authors:Stein, A.J., White, A., Suto, R.K.
Deposit date:2013-02-05
Release date:2014-01-15
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist.
Plos One, 8, 2013