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1YJE
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CRYSTAL STRUCTURE OF THE RNGFI-B LIGAND-BINDING DOMAIN
Descriptor:Orphan nuclear receptor NR4A1
Authors:Flaig, R., Greschik, H., Peluso-Iltis, C., Moras, D., Structural Proteomics in Europe (SPINE)
Deposit date:2005-01-14
Release date:2005-02-22
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for the cell-specific activities of the NGFI-B and the Nurr1 ligand-binding domain.
J.Biol.Chem., 280, 2005
5AFW
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ASSEMBLY OF METHYLATED LSD1 AND CHD1 DRIVES AR-DEPENDENT TRANSCRIPTION AND TRANSLOCATION
Descriptor:CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, 1,2-ETHANEDIOL, ...
Authors:Metzger, E., Willmann, D., McMillan, J., Petroll, K., Metzger, P., Gerhardt, S., vonMaessenhausen, A., Schott, A.K., Espejo, A., Eberlin, A., Wohlwend, D., Schuele, K.M., Schleicher, M., Perner, S., Bedford, M.T., Dengjel, J., Flaig, R., Einsle, O., Schuele, R.
Deposit date:2015-01-26
Release date:2016-01-13
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Assembly of Methylated Kdm1A and Chd1 Drives Androgen Receptor-Dependent Transcription and Translocation.
Nat.Struct.Mol.Biol., 23, 2016
5ANQ
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INHIBITORS OF JUMONJIC DOMAIN-CONTAINING HISTONE DEMETHYLASES
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4A, 2-{2-[(pyridin-3-ylmethyl)amino]pyrimidin-4-yl}pyridine-4-carboxylic acid, FE (II) ION, ...
Authors:Roatsch, M., Robaa, D., Pippel, M., Nettleship, J.E., Reddivari, Y., Bird, L.E., Hoffmann, I., Franz, H., Owens, R.J., Schuele, R., Flaig, R., Sippl, W., Jung, M.
Deposit date:2015-09-07
Release date:2016-03-23
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Substituted 2-(2-Aminopyrimidin-4-Yl)Pyridine-4-Carboxylates as Potent Inhibitors of Jumonjic Domain-Containing Histone Demethylases.
Fut.Med.Chem., 8, 2016
3D24
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CRYSTAL STRUCTURE OF LIGAND-BINDING DOMAIN OF ESTROGEN-RELATED RECEPTOR ALPHA (ERRALPHA) IN COMPLEX WITH THE PEROXISOME PROLIFERATORS-ACTIVATED RECEPTOR COACTIVATOR-1ALPHA BOX3 PEPTIDE (PGC-1ALPHA)
Descriptor:Steroid hormone receptor ERR1, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Authors:Moras, D., Greschik, H., Flaig, R., Sato, Y., Rochel, N., Structural Proteomics in Europe (SPINE)
Deposit date:2008-05-07
Release date:2008-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Communication between the ERR{alpha} Homodimer Interface and the PGC-1{alpha} Binding Surface via the Helix 8-9 Loop.
J.Biol.Chem., 283, 2008
2W1B
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THE STRUCTURE OF THE EFFLUX PUMP ACRB IN COMPLEX WITH BILE ACID
Descriptor:ACRIFLAVIN RESISTANCE PROTEIN B, (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID
Authors:Drew, D., Klepsch, M.M., Newstead, S., Flaig, R., De Gier, J.W., Iwata, S., Beis, K.
Deposit date:2008-10-17
Release date:2008-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.85 Å)
Cite:The Structure of the Efflux Pump Acrb in Complex with Bile Acid.
Mol.Membr.Biol., 25, 2008
1S9P
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CRYSTAL STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE ESTROGEN-RELATED RECEPTOR GAMMA IN COMPLEX WITH DIETHYLSTILBESTROL
Descriptor:Estrogen-related receptor gamma, DIETHYLSTILBESTROL
Authors:Greschik, H., Flaig, R., Renaud, J.P., Moras, D.
Deposit date:2004-02-05
Release date:2004-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structural Basis for the Deactivation of the Estrogen-related Receptor {gamma} by Diethylstilbestrol or 4-Hydroxytamoxifen and Determinants of Selectivity.
J.Biol.Chem., 279, 2004
1S9Q
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CRYSTAL STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE ESTROGEN-RELATED RECEPTOR GAMMA IN COMPLEX WITH 4-HYDROXYTAMOXIFEN
Descriptor:Estrogen-related receptor gamma, 4-HYDROXYTAMOXIFEN, CHOLIC ACID
Authors:Greschik, H., Flaig, R., Renaud, J.P., Moras, D.
Deposit date:2004-02-05
Release date:2004-06-08
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for the Deactivation of the Estrogen-related Receptor {gamma} by Diethylstilbestrol or 4-Hydroxytamoxifen and Determinants of Selectivity.
J.Biol.Chem., 279, 2004
1TFC
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CRYSTAL STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE ESTROGEN-RELATED RECEPTOR GAMMA IN COMPLEX WITH A STEROID RECEPTOR COACTIVATOR-1 PEPTIDE
Descriptor:Estrogen-related receptor gamma, steroid receptor coactivator-1
Authors:Greschik, H., Flaig, R., Renaud, J.P., Moras, D.
Deposit date:2004-05-27
Release date:2004-07-27
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for the Deactivation of the Estrogen-related Receptor {gamma} by Diethylstilbestrol or 4-Hydroxytamoxifen and Determinants of Selectivity.
J.Biol.Chem., 279, 2004
1VJB
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CRYSTAL STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE ESTROGEN-RELATED RECEPTOR GAMMA IN COMPLEX WITH 4-HYDROXYTAMOXIFEN
Descriptor:Estrogen-related receptor gamma, 4-HYDROXYTAMOXIFEN
Authors:Greschik, H., Flaig, R., Renaud, J.P., Moras, D.
Deposit date:2004-02-03
Release date:2004-06-08
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Basis for the Deactivation of the Estrogen-related Receptor {gamma} by Diethylstilbestrol or 4-Hydroxytamoxifen and Determinants of Selectivity.
J.Biol.Chem., 279, 2004