5NFY
| SARS-CoV nsp10/nsp14 dynamic complex | Descriptor: | DI(HYDROXYETHYL)ETHER, Polyprotein 1ab, ZINC ION | Authors: | Ferron, F, Gluais, L, Vonrhein, C, Bricogne, G, Canard, B, Imbert, I. | Deposit date: | 2017-03-16 | Release date: | 2018-01-10 | Last modified: | 2019-02-20 | Method: | X-RAY DIFFRACTION (3.382 Å) | Cite: | Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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8C0G
| SARS-CoV nsp16-nsp10 complexed with N7-GTP | Descriptor: | DI(HYDROXYETHYL)ETHER, Non-structural protein 7, SODIUM ION, ... | Authors: | Ferron, F, Debarnot, C, Coutard, B, Canard, B, Marseilles Structural Genomics Program @ AFMB (MSGP) | Deposit date: | 2022-12-16 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Observation of N7-GTP in nsp16-nsp10 Sars-CoV To Be Published
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3OV9
| Structure of the Nucleoprotein from Rift Valley Fever Virus | Descriptor: | NITRITE ION, Nucleoprotein, SODIUM ION | Authors: | Ferron, F, Danek, E.I, Li, Z, Luo, D, Wong, Y.H, Coutard, B, Lantez, V, Charrel, R, Canard, B, Walz, T, Lescar, J. | Deposit date: | 2010-09-16 | Release date: | 2011-05-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes Plos Pathog., 7, 2011
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3OUO
| Structure of the Nucleoprotein from Rift Valley Fever Virus | Descriptor: | NITRITE ION, Nucleoprotein | Authors: | Ferron, F, Danek, E.I, Li, Z, Luo, D, Wong, Y.H, Coutard, B, Lantez, V, Charrel, R, Canard, B, Walz, T, Lescar, J. | Deposit date: | 2010-09-15 | Release date: | 2011-05-25 | Last modified: | 2013-08-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes Plos Pathog., 7, 2011
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2PBD
| Ternary complex of profilin-actin with the poly-PRO-GAB domain of VASP* | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Ferron, F, Rebowski, G, Dominguez, R. | Deposit date: | 2007-03-28 | Release date: | 2007-11-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.501 Å) | Cite: | Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP Embo J., 26, 2007
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2PAV
| Ternary complex of Profilin-Actin with the Last Poly-Pro of Human VASP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Ferron, F, Rebowski, G, Dominguez, R. | Deposit date: | 2007-03-27 | Release date: | 2007-10-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP. Embo J., 26, 2007
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6YU8
| RNA Methyltransferase of Sudan Ebola Virus | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Ferron, F, Valle, C, Zamboni, V, Canard, B, Decroly, E. | Deposit date: | 2020-04-25 | Release date: | 2021-02-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.841 Å) | Cite: | First insights into the structural features of Ebola virus methyltransferase activities. Nucleic Acids Res., 49, 2021
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1QZ8
| Crystal structure of SARS coronavirus NSP9 | Descriptor: | SULFATE ION, polyprotein 1ab | Authors: | Egloff, M.P, Ferron, F, Campanacci, V, Longhi, S, Rancurel, C, Dutartre, H, Snijder, E.J, Gorbalenya, A.E, Cambillau, C, Canard, B. | Deposit date: | 2003-09-16 | Release date: | 2004-02-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world. Proc.Natl.Acad.Sci.USA, 101, 2004
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4UD1
| Structure of the N Terminal domain of the MERS CoV nucleocapsid | Descriptor: | AMMONIUM ION, GLYCEROL, IMIDAZOLE, ... | Authors: | Papageorgiou, N, Lichiere, J, Ferron, F, Canard, B, Coutard, B. | Deposit date: | 2014-12-05 | Release date: | 2015-12-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Structural Characterization of the N-Terminal Part of the Mers-Cov Nucleocapsid by X-Ray Diffraction and Small-Angle X-Ray Scattering Acta Crystallogr.,Sect.D, 72, 2016
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8QCH
| Human Adenosine deaminase-like protein in complex with compound AT8001 | Descriptor: | Adenosine deaminase-like protein, DI(HYDROXYETHYL)ETHER, SODIUM ION, ... | Authors: | Zimberger, C, canard, B, Ferron, F. | Deposit date: | 2023-08-26 | Release date: | 2024-07-31 | Last modified: | 2024-09-04 | Method: | X-RAY DIFFRACTION (2.442 Å) | Cite: | The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution. Plos Biol., 22, 2024
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8CNL
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8BCR
| DENV3 Methyltransferase in complexed with AT-9010 and SAH | Descriptor: | Genome polyprotein, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Gauffre, P, Fattorini, V, Canard, B, Ferron, F. | Deposit date: | 2022-10-17 | Release date: | 2023-03-22 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5. Antiviral Res., 212, 2023
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7Z05
| White Bream virus N7-Methyltransferase | Descriptor: | DI(HYDROXYETHYL)ETHER, Non-structural protein 1, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Shannon, A, Gauffre, P, Canard, B, Ferron, F. | Deposit date: | 2022-02-22 | Release date: | 2022-09-28 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome. Nucleic Acids Res., 50, 2022
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7Z2J
| White Bream virus N7-Methyltransferase | Descriptor: | Non-structural protein 1, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Shannon, A, Gauffre, P, Canard, B, Ferron, F. | Deposit date: | 2022-02-28 | Release date: | 2022-11-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.657 Å) | Cite: | A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome. Nucleic Acids Res., 50, 2022
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7OA4
| Crystal structure of the N-terminal endonuclease domain of La Crosse virus L-protein bound to compound L-742,001 | Descriptor: | (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, FORMIC ACID, MANGANESE (II) ION, ... | Authors: | Feracci, M, Hernandez, S, Vincentelli, R, Ferron, F, Reguera, J, Canard, B, Alvarez, K. | Deposit date: | 2021-04-19 | Release date: | 2022-08-03 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Biophysical and structural study of La Crosse virus endonuclease inhibition for the development of new antiviral options. Iucrj, 11, 2024
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7PLR
| Crystal structure of the N-terminal endonuclease domain of La Crosse virus L-protein bound to compound Baloxavir | Descriptor: | Baloxavir acid, FORMIC ACID, GLYCEROL, ... | Authors: | Feracci, M, Hernandez, S, Vincentelli, R, Ferron, F, Reguera, J, Canard, B, Alvarez, K. | Deposit date: | 2021-09-01 | Release date: | 2022-09-14 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | Biophysical and structural study of La Crosse virus endonuclease inhibition for the development of new antiviral options. Iucrj, 11, 2024
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7ED5
| A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase | Descriptor: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | Authors: | Shannon, A, Fattorini, V, Sama, B, Selisko, B, Feracci, M, Falcou, C, Gauffre, P, El Kazzi, P, Delpal, A, Decroly, E, Alvarez, K, Eydoux, C, Guillemot, J.-C, Moussa, A, Good, S, Colla, P, Lin, K, Sommadossi, J.-P, Zhu, Y.X, Yan, X.D, Shi, H, Ferron, F, Canard, B. | Deposit date: | 2021-03-15 | Release date: | 2022-02-16 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase. Nat Commun, 13, 2022
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8CB3
| SARS-CoV Macro domain complexed with 3-(N-morpholino)propanesulfonic acid | Descriptor: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, GLYCEROL, Papain-like protease nsp3 | Authors: | Morin, B, Ferron, F, Coutard, B, Canard, B, Marseilles Structural Genomics Program @ AFMB (MSGP) | Deposit date: | 2023-01-25 | Release date: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.572 Å) | Cite: | SARS-CoV Macro domain complexed with 3-(N-morpholino)propanesulfonic acid To Be Published
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5FVA
| Toscana Virus Nucleocapsid Protein | Descriptor: | NUCLEOPROTEIN, SODIUM ION | Authors: | Baklouti, A, Sevajol, M, Goulet, A, Lichiere, J, Ferron, F, Canard, B, Charrel, R.N, Coutard, B, Papageorgiou, N. | Deposit date: | 2016-02-03 | Release date: | 2016-03-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Toscana virus nucleoprotein oligomer organization observed in solution. Acta Crystallogr D Struct Biol, 73, 2017
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8PWK
| human HINT1 in complex with compound AT8003 | Descriptor: | Histidine triad nucleotide-binding protein 1, SODIUM ION, [(2~{R},3~{R},4~{R},5~{R})-5-[2-azanyl-6-(methylamino)purin-9-yl]-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate | Authors: | Zimberger, C, Canard, B, Ferron, F. | Deposit date: | 2023-07-20 | Release date: | 2024-07-31 | Last modified: | 2024-09-04 | Method: | X-RAY DIFFRACTION (2.095 Å) | Cite: | The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution. Plos Biol., 22, 2024
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8PTS
| human GUK1 in complex with compound AT8001 | Descriptor: | GLYCEROL, Guanylate kinase, [(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate | Authors: | Zimberger, C, Canard, B, Ferron, F. | Deposit date: | 2023-07-14 | Release date: | 2024-07-24 | Last modified: | 2024-09-04 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution. Plos Biol., 22, 2024
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8PIE
| Crystal structure of the human nucleoside diphosphate kinase B domain in complex with the product AT-8500 formed by catalysis of compound AT-9010 | Descriptor: | GLYCEROL, Nucleoside diphosphate kinase B, [(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl phosphono hydrogen phosphate | Authors: | Feracci, M, Chazot, A, Ferron, F, Alvarez, K, Canard, B. | Deposit date: | 2023-06-21 | Release date: | 2024-07-31 | Last modified: | 2024-09-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution. Plos Biol., 22, 2024
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8RCQ
| Structural flexibility of Nucleoprotein of the Toscana virus in the presence of a nanobody. | Descriptor: | Nucleoprotein, VHH | Authors: | Papageorgiou, N, Ferron, F, Coutard, B, Lichiere, J, Baklouti, A. | Deposit date: | 2023-12-06 | Release date: | 2024-01-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structural flexibility of Toscana virus nucleoprotein in the presence of a single-chain camelid antibody. Acta Crystallogr D Struct Biol, 80, 2024
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2XYV
| Crystal structure of the nsp16 nsp10 SARS coronavirus complex | Descriptor: | CHLORIDE ION, MAGNESIUM ION, NON-STRUCTURAL PROTEIN 10, ... | Authors: | Decroly, E, Debarnot, C, Ferron, F, Bouvet, M, Coutard, B, Imbert, I, Gluais, L, Papageorgiou, N, Ortiz-Lombardia, M, Lescar, J, Canard, B. | Deposit date: | 2010-11-19 | Release date: | 2011-10-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Crystal Structure and Functional Analysis of the Sars-Coronavirus RNA CAP 2'-O-Methyltransferase Nsp10/Nsp16 Complex. Plos Pathog., 7, 2011
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2XYR
| Crystal structure of the nsp16 nsp10 SARS coronavirus complex | Descriptor: | CHLORIDE ION, MAGNESIUM ION, NON-STRUCTURAL PROTEIN 10, ... | Authors: | Decroly, E, Debarnot, C, Ferron, F, Bouvet, M, Coutard, B, Imbert, I, Gluais, L, Papageorgiou, N, Ortiz-Lombardia, M, Lescar, J, Canard, B. | Deposit date: | 2010-11-18 | Release date: | 2011-10-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure and Functional Analysis of the Sars-Coronavirus RNA CAP 2'-O-Methyltransferase Nsp10/Nsp16 Complex. Plos Pathog., 7, 2011
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