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2BOY
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CRYSTAL STRUCTURE OF 3-CHLOROCATECHOL 1,2-DIOXYGENASE FROM RHODOCOCCUS OPACUS 1CP
Descriptor:3-CHLOROCATECHOL 1,2-DIOXYGENASE, FE (III) ION, BENZHYDROXAMIC ACID, ...
Authors:Ferraroni, M., Solyanikova, I.P., Kolomytseva, M.P., Scozzafava, A., Golovleva, L.A., Briganti, F.
Deposit date:2005-04-15
Release date:2006-08-24
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of 3-chlorocatechol 1,2-dioxygenase key enzyme of a new modified ortho-pathway from the Gram-positive Rhodococcus opacus 1CP grown on 2-chlorophenol.
J. Mol. Biol., 360, 2006
1TMX
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CRYSTAL STRUCTURE OF HYDROXYQUINOL 1,2-DIOXYGENASE FROM NOCARDIOIDES SIMPLEX 3E
Descriptor:hydroxyquinol 1,2-dioxygenase, FE (III) ION, COPPER (II) ION, ...
Authors:Ferraroni, M., Travkin, V.M., Seifert, J., Schlomann, M., Golovleva, L., Scozzafava, A., Briganti, F.
Deposit date:2004-06-11
Release date:2005-03-22
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of the hydroxyquinol 1,2-dioxygenase from Nocardioides simplex 3E, a key enzyme involved in polychlorinated aromatics biodegradation.
J.Biol.Chem., 280, 2005
3O32
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CRYSTAL STRUCTURE OF 4-CHLOROCATECHOL DIOXYGENASE FROM RHODOCOCCUS OPACUS 1CP IN COMPLEX WITH 3,5-DICHLOROCATECHOL
Descriptor:Chlorocatechol 1,2-dioxygenase, FE (III) ION, 3,5-dichlorobenzene-1,2-diol, ...
Authors:Ferraroni, M., Briganti, F., Kolomytseva, M., Golovleva, L.
Deposit date:2010-07-23
Release date:2011-08-10
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:X-ray structures of 4-chlorocatechol 1,2-dioxygenase adducts with substituted catechols: new perspectives in the molecular basis of intradiol ring cleaving dioxygenases specificity.
J. Struct. Biol., 181, 2013
3O5U
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CRYSTAL STRUCTURE OF 4-CHLOROCATECHOL DIOXYGENASE FROM RHODOCOCCUS OPACUS 1CP IN COMPLEX WITH PROTOCATECHUATE
Descriptor:Chlorocatechol 1,2-dioxygenase, FE (III) ION, (2R)-3-(PHOSPHONOOXY)-2-(TETRADECANOYLOXY)PROPYL PALMITATE, ...
Authors:Ferraroni, M., Briganti, F., Kolomitseva, M., Golovleva, L.
Deposit date:2010-07-28
Release date:2011-08-17
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:X-ray structures of 4-chlorocatechol 1,2-dioxygenase adducts with substituted catechols: new perspectives in the molecular basis of intradiol ring cleaving dioxygenases specificity.
J. Struct. Biol., 181, 2013
3O6J
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CRYSTAL STRUCTURE OF 4-CHLOROCATECHOL DIOXYGENASE FROM RHODOCOCCUS OPACUS 1CP IN COMPLEX WITH HYDROXYQUINOL
Descriptor:Chlorocatechol 1,2-dioxygenase, FE (III) ION, (2R)-3-(PHOSPHONOOXY)-2-(TETRADECANOYLOXY)PROPYL PALMITATE, ...
Authors:Ferraroni, M., Briganti, F., Kolomitseva, M., Golovleva, L.
Deposit date:2010-07-29
Release date:2011-08-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:X-ray structures of 4-chlorocatechol 1,2-dioxygenase adducts with substituted catechols: new perspectives in the molecular basis of intradiol ring cleaving dioxygenases specificity.
J. Struct. Biol., 181, 2013
3O6R
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CRYSTAL STRUCTURE OF 4-CHLOROCATECHOL DIOXYGENASE FROM RHODOCOCCUS OPACUS 1CP IN COMPLEX WITH PYROGALLOL
Descriptor:Chlorocatechol 1,2-dioxygenase, FE (III) ION, (2R)-3-(PHOSPHONOOXY)-2-(TETRADECANOYLOXY)PROPYL PALMITATE, ...
Authors:Ferraroni, M., Briganti, F., Kolomitseva, M., Golovleva, L.
Deposit date:2010-07-29
Release date:2011-08-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:X-ray structures of 4-chlorocatechol 1,2-dioxygenase adducts with substituted catechols: new perspectives in the molecular basis of intradiol ring cleaving dioxygenases specificity.
J. Struct. Biol., 181, 2013
3T6V
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CRYSTAL STRUCTURE OF LACCASE FROM STECCHERINUM OCHRACEUM
Descriptor:Laccase, COPPER (II) ION, SULFATE ION, ...
Authors:Ferraroni, M., Briganti, F., Matera, I., Kolomytseva, M., Golovleva, L., Scozzafava, A., Chernykh, A.M.
Deposit date:2011-07-29
Release date:2012-04-18
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Reaction intermediates and redox state changes in a blue laccase from Steccherinum ochraceum observed by crystallographic high/low X-ray dose experiments.
J.Inorg.Biochem., 111, 2012
3T6W
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CRYSTAL STRUCTURE OF STECCHERINUM OCHRACEUM LACCASE OBTAINED BY MULTI-CRYSTALS COMPOSITE DATA COLLECTION TECHNIQUE (10% DOSE)
Descriptor:Laccase, COPPER (II) ION, SULFATE ION, ...
Authors:Ferraroni, M., Briganti, F., Matera, I., Kolomytseva, M., Golovleva, L., Scozzafava, A., Chernykh, A.M.
Deposit date:2011-07-29
Release date:2012-04-18
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Reaction intermediates and redox state changes in a blue laccase from Steccherinum ochraceum observed by crystallographic high/low X-ray dose experiments.
J.Inorg.Biochem., 111, 2012
3T6X
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CRYSTAL STRUCTURE OF STECCHERINUM OCHRACEUM LACCASE OBTAINED BY MULTI-CRYSTALS COMPOSITE DATA COLLECTION TECHNIQUE (20% DOSE)
Descriptor:Laccase, COPPER (II) ION, SULFATE ION, ...
Authors:Ferraroni, M., Briganti, F., Matera, I., Kolomytseva, M., Golovleva, L., Scozzafava, A., Chernykh, A.M.
Deposit date:2011-07-29
Release date:2012-04-18
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Reaction intermediates and redox state changes in a blue laccase from Steccherinum ochraceum observed by crystallographic high/low X-ray dose experiments.
J.Inorg.Biochem., 111, 2012
3T6Z
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CRYSTAL STRUCTURE OF STECCHERINUM OCHRACEUM LACCASE OBTAINED BY MULTI-CRYSTALS COMPOSITE DATA COLLECTION TECHNIQUE (60% DOSE)
Descriptor:Laccase, COPPER (II) ION, SULFATE ION, ...
Authors:Ferraroni, M., Briganti, F., Matera, I., Kolomytseva, M., Golovleva, L., Scozzafava, A., Chernykh, A.M.
Deposit date:2011-07-29
Release date:2012-04-18
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Reaction intermediates and redox state changes in a blue laccase from Steccherinum ochraceum observed by crystallographic high/low X-ray dose experiments.
J.Inorg.Biochem., 111, 2012
3T71
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CRYSTAL STRUCTURE OF STECCHERINUM OCHRACEUM LACCASE OBTAINED BY MULTI-CRYSTALS COMPOSITE DATA COLLECTION TECHNIQUE (90% DOSE)
Descriptor:Laccase, COPPER (II) ION, SULFATE ION, ...
Authors:Ferraroni, M., Briganti, F., Matera, I., Kolomytseva, M., Golovleva, L., Scozzafava, A., Chernykh, A.M.
Deposit date:2011-07-29
Release date:2012-04-18
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Reaction intermediates and redox state changes in a blue laccase from Steccherinum ochraceum observed by crystallographic high/low X-ray dose experiments.
J.Inorg.Biochem., 111, 2012
4FPI
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CRYSTAL STRUCTURE OF 5-CHLOROMUCONOLACTONE ISOMERASE FROM RHODOCOCCUS OPACUS 1CP
Descriptor:5-chloromuconolactone dehalogenase
Authors:Ferraroni, M., Kolomytseva, M., Briganti, F., Golovleva, L.A., Scozzafava, A.
Deposit date:2012-06-22
Release date:2013-04-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray crystallographic and molecular docking studies on a unique chloromuconolactone dehalogenase from Rhodococcus opacus 1CP.
J.Struct.Biol., 182, 2013
5NEA
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CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THE INHIBITOR 4-(2-METHYL-1,3-OXAZOL-5-YL)BENZENE-1-SULFONAMMIDE
Descriptor:Carbonic anhydrase 2, ZINC ION, 4-(2-methyl-1,3-oxazol-5-yl)benzenesulfonamide, ...
Authors:Ferraroni, M., Supuran, C.T., Krasavin, M.
Deposit date:2017-03-10
Release date:2017-12-06
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads.
Bioorg. Med. Chem., 25, 2017
5NEE
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CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THE INHIBITOR 5-[2-(MORPHOLINE-4-CARBONYL)1,3-OXAZOL-5-YL)]THIOPHENE-2-SULFONAMMIDE
Descriptor:Carbonic anhydrase 2, ZINC ION, 5-(2-morpholin-4-ylcarbonyl-1,3-oxazol-5-yl)thiophene-2-sulfonamide, ...
Authors:Ferraroni, M., Supuran, C.T., Krasavin, M.
Deposit date:2017-03-10
Release date:2017-12-06
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads.
Bioorg. Med. Chem., 25, 2017
6I0J
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CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE I IN COMPLEX WITH THE 4-({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]CARBAMOYL}AMINO)PHENYL SULFAMATE INHIBITOR
Descriptor:Carbonic anhydrase 1, ZINC ION, ACETATE ION, ...
Authors:Ferraroni, M., Supuran, C.T., Bozdag, M., Chiapponi, D.
Deposit date:2018-10-26
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:New classes of carbonic anhydrase inhibitors
to be published
6I0L
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CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE I IN COMPLEX WITH THE 1-[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]-3-[2-(4-SULFAMOYLPHENYL)ETHYL]UREA INHIBITOR
Descriptor:Carbonic anhydrase 1, ZINC ION, 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-[2-(4-sulfamoylphenyl)ethyl]urea, ...
Authors:Ferraroni, M., Supuran, C.T., Bozdag, M., Chiapponi, D.
Deposit date:2018-10-26
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:New classes of carbonic anhydrase inhibitors
to be published
4KUV
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CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THE 5-(3-(4-CHLOROPHENYLSULFONYL)UREIDO)PYRIDINE-2-SULFONAMIDE INHIBITOR
Descriptor:Carbonic anhydrase 2, ZINC ION, 5-({[(4-chlorophenyl)sulfonyl]carbamoyl}amino)pyridine-2-sulfonamide, ...
Authors:Ferraroni, M.
Deposit date:2013-05-22
Release date:2014-06-25
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:New classes of carbonic anhydrase inhibitors
to be published
4KUW
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CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THE 5-(3-(4-FLUOROPHENYLSULFONYL)UREIDO)PYRIDINE-2-SULFONAMIDE INHIBITOR
Descriptor:Carbonic anhydrase 2, ZINC ION, GLYCEROL, ...
Authors:Ferraroni, M.
Deposit date:2013-05-22
Release date:2014-06-25
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:New classes of carbonic anhydrase inhibitors
to be published
4KUY
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CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THE 5-(3-(O-TOLYLSULFONYL)UREIDO)PYRIDINE-2-SULFONAMIDE INHIBITOR
Descriptor:Carbonic anhydrase 2, ZINC ION, BETA-MERCAPTOETHANOL, ...
Authors:Ferraroni, M.
Deposit date:2013-05-22
Release date:2014-06-25
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:New classes of carbonic anhydrase inhibitors
to be published
4RH2
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CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-5-{3-1-(4-SULFAMOYL-PHENYL)-1H-[1,2,3]TRIAZOL-4-YLMETHYL-THIOUREIDO}-BENZOIC ACID
Descriptor:Carbonic anhydrase 2, ZINC ION, 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-5-[({[1-(4-sulfamoylphenyl)-1H-1,2,3-triazol-4-yl]methyl}carbamothioyl)amino]benzoic acid, ...
Authors:Ferraroni, M.
Deposit date:2014-10-01
Release date:2015-11-11
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:New classes of carbonic anhydrase inhibitors
to be published
4WL4
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CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THE 6-HYDROXY-CHROMENE-2-THIONE INHIBITOR
Descriptor:Carbonic anhydrase 2, ZINC ION, 6-hydroxy-2H-chromene-2-thione, ...
Authors:Ferraroni, M.
Deposit date:2014-10-06
Release date:2015-10-14
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:New classes of carbonic anhydrase inhibitors
to be published
5LM8
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CRYSTAL STRUCTURE OF A LACCASE-LIKE MULTICOPPER OXIDASE MCOG FROM FROM ASPERGILLUS NIGER
Descriptor:'Multicopper oxidase, COPPER (II) ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Ferraroni, M., Briganti, F., Tamayo-Ramos, J.A., van Berkel, W.J.H., Westphal, A.H.
Deposit date:2016-07-29
Release date:2017-05-03
Last modified:2017-07-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and function of Aspergillus niger laccase McoG
Biocatalysis, 2017
5LWW
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CRYSTAL STRUCTURE OF A LACCASE-LIKE MULTICOPPER OXIDASE MCOG FROM ASPERGILLUS NIGER BOUND TO ZINC
Descriptor:Multicopper oxidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Ferraroni, M., Briganti, F., Tamayo-Ramos, J.A., van Berkel, W.J.H., Westphal, A.H.
Deposit date:2016-09-19
Release date:2017-05-03
Last modified:2017-07-19
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure and function of Aspergillus niger laccase McoG
Biocatalysis, 2017
5LWX
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CRYSTAL STRUCTURE OF THE H253D MUTANT OF MCOG FROM ASPERGILLUS NIGER
Descriptor:Multicopper oxidase, COPPER (II) ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Ferraroni, M., Briganti, F., Tamayo-Ramos, J.A., van Berkel, W.J.H., Westphal, A.H.
Deposit date:2016-09-19
Release date:2017-05-03
Last modified:2017-07-19
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structure and function of Aspergillus niger laccase McoG
Biocatalysis, 2017
1MFM
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MONOMERIC HUMAN SOD MUTANT F50E/G51E/E133Q AT ATOMIC RESOLUTION
Descriptor:PROTEIN (COPPER,ZINC SUPEROXIDE DISMUTASE), ZINC ION, COPPER (II) ION, ...
Authors:Ferraroni, M., Rypniewski, W., Wilson, K.S., Orioli, P.L., Viezzoli, M.S., Banci, L., Bertini, I., Mangani, S.
Deposit date:1999-04-16
Release date:1999-04-21
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.02 Å)
Cite:The crystal structure of the monomeric human SOD mutant F50E/G51E/E133Q at atomic resolution. The enzyme mechanism revisited.
J.Mol.Biol., 288, 1999