5NEE

Crystal structure of human carbonic anhydrase II in complex with the inhibitor 5-[2-(morpholine-4-carbonyl)1,3-oxazol-5-yl)]thiophene-2-sulfonammide

Summary for 5NEE

Entry DOI	10.2210/pdb5nee/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, 5-(2-morpholin-4-ylcarbonyl-1,3-oxazol-5-yl)thiophene-2-sulfonamide, ... (5 entities in total)
Functional Keywords	lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29789.94
Authors	Ferraroni, M.,Supuran, C.T.,Krasavin, M. (deposition date: 2017-03-10, release date: 2017-12-06, Last modification date: 2024-01-17)
Primary citation	Ferraroni, M.,Lucarini, L.,Masini, E.,Korsakov, M.,Scozzafava, A.,Supuran, C.T.,Krasavin, M. 1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads. Bioorg. Med. Chem., 25:4560-4565, 2017 Cited by PubMed: 28728897 DOI: 10.1016/j.bmc.2017.06.054 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation