3J4J | | MODEL OF FULL-LENGTH T. THERMOPHILUS TRANSLATION INITIATION FACTOR 2 REFINED AGAINST ITS CRYO-EM DENSITY FROM A 30S INITIATION COMPLEX MAP | | Descriptor: | Translation initiation factor IF-2 | | Authors: | Simonetti, A., Marzi, S., Billas, I.M.L., Tsai, A., Fabbretti, A., Myasnikov, A., Roblin, P., Vaiana, A.C., Hazemann, I., Eiler, D., Steitz, T.A., Puglisi, J.D., Gualerzi, C.O., Klaholz, B.P. | | Deposit date: | 2013-08-26 | | Release date: | 2013-09-25 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (11.5 Å) | | Cite: | Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4V9R | | CRYSTAL STRUCTURE OF ANTIBIOTIC DITYROMYCIN BOUND TO 70S RIBOSOME | | Descriptor: | 16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ... | | Authors: | Bulkley, D.P., Brandi, L., Polikanov, Y.S., Fabbretti, A., O'Connor, M., Gualerzi, C.O., Steitz, T.A. | | Deposit date: | 2013-12-05 | | Release date: | 2014-07-09 | | Last modified: | 2014-12-10 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.
Cell Rep, 6, 2014
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4V9S | | CRYSTAL STRUCTURE OF ANTIBIOTIC GE82832 BOUND TO 70S RIBOSOME | | Descriptor: | 16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ... | | Authors: | Bulkley, D.P., Brandi, L., Polikanov, Y.S., Fabbretti, A., O'Connor, M., Gualerzi, C.O., Steitz, T.A. | | Deposit date: | 2013-12-05 | | Release date: | 2014-07-09 | | Last modified: | 2018-06-27 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.
Cell Rep, 6, 2014
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5ME0 | | STRUCTURE OF THE 30S PRE-INITIATION COMPLEX 1 (30S IC-1) STALLED BY GE81112 | | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ... | | Authors: | Lopez-Alonso, J.P., Fabbretti, A., Kaminishi, T., Iturrioz, I., Brandi, L., Gil Carton, D., Gualerzi, C., Fucini, P., Connell, S. | | Deposit date: | 2016-11-14 | | Release date: | 2017-01-11 | | Last modified: | 2018-11-21 | | Method: | ELECTRON MICROSCOPY (13.5 Å) | | Cite: | Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways.
Nucleic Acids Res., 45, 2017
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5ME1 | | STRUCTURE OF THE 30S PRE-INITIATION COMPLEX 2 (30S IC-2) STALLED BY GE81112 | | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ... | | Authors: | Lopez-Alonso, J.P., Fabbretti, A., Kaminishi, T., Iturrioz, I., Brandi, L., Gil Carton, D., Gualerzi, C., Fucini, P., Connell, S. | | Deposit date: | 2016-11-14 | | Release date: | 2017-01-11 | | Last modified: | 2018-11-21 | | Method: | ELECTRON MICROSCOPY (13.5 Å) | | Cite: | Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways.
Nucleic Acids Res., 45, 2017
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5IWA | | CRYSTAL STRUCTURE OF THE 30S RIBOSOMAL SUBUNIT FROM THERMUS THERMOPHILUS IN COMPLEX WITH THE GE81112 PEPTIDE ANTIBIOTIC | | Descriptor: | 30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, ... | | Authors: | Schedlbauer, A., Kaminishi, T., Ochoa-Lizarralde, B., Chieko, N., Masahito, K., Takemoto, C., Yokoyama, S., Connell, S.R., Fucini, P. | | Deposit date: | 2016-03-22 | | Release date: | 2016-04-27 | | Last modified: | 2017-04-05 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Inhibition of translation initiation complex formation by GE81112 unravels a 16S rRNA structural switch involved in P-site decoding.
Proc.Natl.Acad.Sci.USA, 113, 2016
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4B3X | | BACTERIAL TRANSLATION INITIATION FACTOR IF2 (1-363), APO FORM | | Descriptor: | TRANSLATION INITIATION FACTOR IF-2, GLYCEROL | | Authors: | Simonetti, A., Urzhumtsev, A., Klaholz, B.P. | | Deposit date: | 2012-07-26 | | Release date: | 2013-05-29 | | Last modified: | 2013-06-05 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structure of the Protein Core of Translation Initiation Factor 2 in Apo, GTP-Bound and Gdp-Bound Forms
Acta Crystallogr.,Sect.D, 69, 2013
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4B43 | | BACTERIAL TRANSLATION INITIATION FACTOR IF2 (1-363), APO FORM, DOUBLE MUTANT K86L H130A | | Descriptor: | TRANSLATION INITIATION FACTOR IF-2, MAGNESIUM ION, GLYCEROL, ... | | Authors: | Simonetti, A., Urzhumtsev, A., Klaholz, B.P. | | Deposit date: | 2012-07-27 | | Release date: | 2013-09-18 | | Method: | X-RAY DIFFRACTION (1.937 Å) | | Cite: | Molecular Basis of GTP Hydrolysis by Bacterial Translation Initiation Factor If2
To be Published
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4B44 | |
4B47 | | BACTERIAL TRANSLATION INITIATION FACTOR IF2 (1-363), COMPLEX WITH GDP AT PH6.5 | | Descriptor: | TRANSLATION INITIATION FACTOR IF-2, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Simonetti, A., Urzhumtsev, A., Klaholz, B.P. | | Deposit date: | 2012-07-27 | | Release date: | 2013-05-29 | | Last modified: | 2015-02-11 | | Method: | X-RAY DIFFRACTION (2.301 Å) | | Cite: | Structure of the Protein Core of Translation Initiation Factor 2 in Apo, GTP-Bound and Gdp-Bound Forms
Acta Crystallogr.,Sect.D, 69, 2013
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4B48 | | BACTERIAL TRANSLATION INITIATION FACTOR IF2 (1-363), COMPLEX WITH GTP | | Descriptor: | TRANSLATION INITIATION FACTOR IF-2, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | | Authors: | Simonetti, A., Urzhumtsev, A., Klaholz, B.P. | | Deposit date: | 2012-07-27 | | Release date: | 2013-05-29 | | Last modified: | 2013-06-05 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of the Protein Core of Translation Initiation Factor 2 in Apo, GTP-Bound and Gdp-Bound Forms
Acta Crystallogr.,Sect.D, 69, 2013
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5DM6 | | CRYSTAL STRUCTURE OF THE 50S RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS | | Descriptor: | 50S ribosomal protein L1, 50S ribosomal protein L2, 50S ribosomal protein L3, ... | | Authors: | Kaminishi, T., Schedlbauer, A., Ochoa-Lizarralde, B., Connell, S.R., Fucini, P. | | Deposit date: | 2015-09-08 | | Release date: | 2015-11-11 | | Last modified: | 2016-02-03 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A.
Nucleic Acids Res., 43, 2015
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5DM7 | | CRYSTAL STRUCTURE OF THE 50S RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS IN COMPLEX WITH HYGROMYCIN A | | Descriptor: | 50S ribosomal protein L1, 50S ribosomal protein L2, 50S ribosomal protein L3, ... | | Authors: | Kaminishi, T., Schedlbauer, A., Ochoa-Lizarralde, B., Connell, S.R., Fucini, P. | | Deposit date: | 2015-09-08 | | Release date: | 2015-11-11 | | Last modified: | 2015-11-25 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A.
Nucleic Acids Res., 43, 2015
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