Author results

2AD5
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MECHANISMS OF FEEDBACK REGULATION AND DRUG RESISTANCE OF CTP SYNTHETASES: STRUCTURE OF THE E. COLI CTPS/CTP COMPLEX AT 2.8-ANGSTROM RESOLUTION.
Descriptor:CTP synthase, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Endrizzi, J.A., Kim, H., Anderson, P.M., Baldwin, E.P.
Deposit date:2005-07-19
Release date:2005-11-01
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanisms of Product Feedback Regulation and Drug Resistance in Cytidine Triphosphate Synthetases from the Structure of a CTP-Inhibited Complex(,).
Biochemistry, 44, 2005
1DCH
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CRYSTAL STRUCTURE OF DCOH, A BIFUNCTIONAL, PROTEIN-BINDING TRANSCRIPTION COACTIVATOR
Descriptor:DCOH (DIMERIZATION COFACTOR OF HNF-1), SULFATE ION
Authors:Endrizzi, J.A., Cronk, J.D., Wang, W., Crabtree, G.R., Alber, T.
Deposit date:1995-01-24
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of DCoH, a bifunctional, protein-binding transcriptional coactivator.
Science, 268, 1995
1EKX
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THE ISOLATED, UNREGULATED CATALYTIC TRIMER OF ASPARTATE TRANSCARBAMOYLASE COMPLEXED WITH BISUBSTRATE ANALOG PALA (N-(PHOSPHONACETYL)-L-ASPARTATE)
Descriptor:ASPARTATE TRANSCARBAMOYLASE, N-(PHOSPHONACETYL)-L-ASPARTIC ACID, CALCIUM ION
Authors:Endrizzi, J.A., Beernink, P.T., Alber, T., Schachman, H.K.
Deposit date:2000-03-09
Release date:2000-05-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: implications for allosteric regulation induced cell migration.
Proc.Natl.Acad.Sci.USA, 97, 2000
1S1M
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CRYSTAL STRUCTURE OF E. COLI CTP SYNTHETASE
Descriptor:CTP synthase, SULFATE ION, MAGNESIUM ION, ...
Authors:Endrizzi, J.A., Kim, H., Anderson, P.M., Baldwin, E.P.
Deposit date:2004-01-06
Release date:2004-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Escherichia coli Cytidine Triphosphate Synthetase, a Nucleotide-Regulated Glutamine Amidotransferase/ATP-Dependent Amidoligase Fusion Protein and Homologue of Anticancer and Antiparasitic Drug Targets
Biochemistry, 43, 2004
1YSC
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2.8 ANGSTROMS STRUCTURE OF YEAST SERINE CARBOXYPEPTIDASE
Descriptor:SERINE CARBOXYPEPTIDASE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE
Authors:Endrizzi, J.A., Remington, S.J.
Deposit date:1994-03-08
Release date:1994-06-22
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:2.8-A structure of yeast serine carboxypeptidase
Biochemistry, 33, 1994
5VMQ
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STRUCTURE OF THE R105A MUTANT CATALYTIC TRIMER OF ESCHERICHIA COLI ASPARTATE TRANSCARBAMOYLASE AT 2.0-A RESOLUTION
Descriptor:Aspartate carbamoyltransferase, CALCIUM ION, CHLORIDE ION
Authors:Beernink, P.T., Endrizzi, J.A.
Deposit date:2017-04-28
Release date:2017-05-24
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.012 Å)
Cite:Charge neutralization in the active site of the catalytic trimer of aspartate transcarbamoylase promotes diverse structural changes.
Protein Sci., 26, 2017
1F93
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CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THE DIMERIZATION DOMAIN OF HNF-1 ALPHA AND THE COACTIVATOR DCOH
Descriptor:DIMERIZATION COFACTOR OF HEPATOCYTE NUCLEAR FACTOR 1-ALPHA, HEPATOCYTE NUCLEAR FACTOR 1-ALPHA
Authors:Rose, R.B., Bayle, J.H., Endrizzi, J.A., Cronk, J.D., Crabtree, G.R., Alber, T.
Deposit date:2000-07-06
Release date:2000-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha.
Nat.Struct.Biol., 7, 2000
1DCO
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DCOH, A BIFUNCTIONAL PROTEIN-BINDING TRANSCRIPTIONAL COACTIVATOR
Descriptor:DCOH
Authors:Cronk, J.D., Endrizzi, J.A., Alber, T.
Deposit date:1996-05-16
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:High-resolution structures of the bifunctional enzyme and transcriptional coactivator DCoH and its complex with a product analogue.
Protein Sci., 5, 1996
1DCP
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DCOH, A BIFUNCTIONAL PROTEIN-BINDING TRANSCRIPTIONAL COACTIVATOR, COMPLEXED WITH BIOPTERIN
Descriptor:DCOH, 7,8-DIHYDROBIOPTERIN
Authors:Cronk, J.D., Endrizzi, J.A., Alber, T.
Deposit date:1996-05-16
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:High-resolution structures of the bifunctional enzyme and transcriptional coactivator DCoH and its complex with a product analogue.
Protein Sci., 5, 1996
1G2Y
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HNF-1ALPHA DIMERIZATION DOMAIN, WITH SELENOMETHIONINE SUBSTITUED AT LEU 12
Descriptor:HEPATOCYTE NUCLEAR FACTOR 1-ALPHA
Authors:Rose, R.B., Endrizzi, J.A., Cronk, J.D., Holton, J., Alber, T.
Deposit date:2000-10-23
Release date:2001-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1 Å)
Cite:High-resolution structure of the HNF-1alpha dimerization domain.
Biochemistry, 39, 2000
1G2Z
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DIMERIZATION DOMAIN OF HNF-1ALPHA WITH A LEU 13 SELENOMETHIONINE SUBSTITUTION
Descriptor:HEPATOCYTE NUCLEAR FACTOR 1-ALPHA
Authors:Rose, R.B., Endrizzi, J.A., Cronk, J.D., Holton, J., Alber, T.
Deposit date:2000-10-23
Release date:2001-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:High-resolution structure of the HNF-1alpha dimerization domain.
Biochemistry, 39, 2000
1G39
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WILD-TYPE HNF-1ALPHA DIMERIZATION DOMAIN
Descriptor:HEPATOCYTE NUCLEAR FACTOR 1-ALPHA
Authors:Rose, R.B., Endrizzi, J.A., Cronk, J.D., Holton, J., Alber, T.
Deposit date:2000-10-23
Release date:2001-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:High-resolution structure of the HNF-1alpha dimerization domain.
Biochemistry, 39, 2000
1I6O
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CRYSTAL STRUCTURE OF E. COLI BETA CARBONIC ANHYDRASE (ECCA)
Descriptor:CARBONIC ANHYDRASE, ZINC ION
Authors:Cronk, J.D., Endrizzi, J.A., Cronk, M.R., O'Neill, J.W., Zhang, K.Y.J.
Deposit date:2001-03-02
Release date:2001-05-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of E. coli beta-carbonic anhydrase, an enzyme with an unusual pH-dependent activity.
Protein Sci., 10, 2001
1I6P
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CRYSTAL STRUCTURE OF E. COLI BETA CARBONIC ANHYDRASE (ECCA)
Descriptor:CARBONIC ANHYDRASE, ZINC ION
Authors:Cronk, J.D., Endrizzi, J.A., Cronk, M.R., O'Neill, J.W., Zhang, K.Y.J.
Deposit date:2001-03-02
Release date:2001-05-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of E. coli beta-carbonic anhydrase, an enzyme with an unusual pH-dependent activity.
Protein Sci., 10, 2001
1D8C
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MALATE SYNTHASE G COMPLEXED WITH MAGNESIUM AND GLYOXYLATE
Descriptor:MALATE SYNTHASE G, D-SORBITOL, MAGNESIUM ION, ...
Authors:Howard, B.R., Endrizzi, J.A., Remington, S.J.
Deposit date:1999-10-22
Release date:1999-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of Escherichia coli malate synthase G complexed with magnesium and glyoxylate at 2.0 A resolution: mechanistic implications.
Biochemistry, 39, 2000
1MRU
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INTRACELLULAR SER/THR PROTEIN KINASE DOMAIN OF MYCOBACTERIUM TUBERCULOSIS PKNB.
Descriptor:Probable serine/threonine-protein kinase pknB, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Young, T.A., Delagoutte, B., Endrizzi, J.A., Alber, T., TB Structural Genomics Consortium (TBSGC)
Deposit date:2002-09-18
Release date:2003-02-11
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of Mycobacterium tuberculosis PknB supports a universal activation mechanism for Ser/Thr protein kinases.
Nat.Struct.Biol., 10, 2003
2A8C
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HAEMOPHILUS INFLUENZAE BETA-CARBONIC ANHYDRASE
Descriptor:Carbonic anhydrase 2, ZINC ION, SULFATE ION
Authors:Cronk, J.D., Rowlett, R.S., Zhang, K.Y.J., Tu, C., Endrizzi, J.A., Lee, J., Gareiss, P.C., Preiss, J.R.
Deposit date:2005-07-07
Release date:2006-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification of a Novel Noncatalytic Bicarbonate Binding Site in Eubacterial beta-Carbonic Anhydrase
Biochemistry, 45, 2006
2A8D
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HAEMOPHILUS INFLUENZAE BETA-CARBONIC ANHYDRASE COMPLEXED WITH BICARBONATE
Descriptor:Carbonic anhydrase 2, ZINC ION, BICARBONATE ION, ...
Authors:Cronk, J.D., Rowlett, R.S., Zhang, K.Y.J., Tu, C., Endrizzi, J.A., Lee, J., Gareiss, P.C., Preiss, J.R.
Deposit date:2005-07-07
Release date:2006-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Identification of a Novel Noncatalytic Bicarbonate Binding Site in Eubacterial beta-Carbonic Anhydrase
Biochemistry, 45, 2006
2ESF
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IDENTIFICATION OF A NOVEL NON-CATALYTIC BICARBONATE BINDING SITE IN EUBACTERIAL BETA-CARBONIC ANHYDRASE
Descriptor:Carbonic anhydrase 2, ZINC ION, BICARBONATE ION
Authors:Cronk, J.D., Rowlett, R.S., Zhang, K.Y.J., Tu, C., Endrizzi, J.A., Gareiss, P.C.
Deposit date:2005-10-26
Release date:2006-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Identification of a Novel Noncatalytic Bicarbonate Binding Site in Eubacterial beta-Carbonic Anhydrase.
Biochemistry, 45, 2006
3CSU
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CATALYTIC TRIMER OF ESCHERICHIA COLI ASPARTATE TRANSCARBAMOYLASE
Descriptor:PROTEIN (ASPARTATE CARBAMOYLTRANSFERASE), CALCIUM ION
Authors:Beernink, P.T., Endrizzi, J.A., Alber, T., Schachman, H.K.
Deposit date:1999-04-22
Release date:1999-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Assessment of the allosteric mechanism of aspartate transcarbamoylase based on the crystalline structure of the unregulated catalytic subunit.
Proc.Natl.Acad.Sci.USA, 96, 1999
3LX4
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STEPWISE [FEFE]-HYDROGENASE H-CLUSTER ASSEMBLY REVEALED IN THE STRUCTURE OF HYDA(DELTAEFG)
Descriptor:Fe-hydrogenase, IRON/SULFUR CLUSTER, CHLORIDE ION, ...
Authors:Mulder, D.W., Boyd, E.S., Sarma, R., Lange, R.K., Endrizzi, J.A., Broderick, J.B., Peters, J.W.
Deposit date:2010-02-24
Release date:2010-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Stepwise [FeFe]-hydrogenase H-cluster assembly revealed in the structure of HydA(DeltaEFG).
Nature, 465, 2010
3PND
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FAD BINDING BY APBE PROTEIN FROM SALMONELLA ENTERICA: A NEW CLASS OF FAD BINDING PROTEINS
Descriptor:Thiamine biosynthesis lipoprotein ApbE, SULFATE ION, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Boyd, J.M., Endrizzi, J.A., Hamilton, T.L., Christopherson, M.R., Mulder, D.W., Downs, D.M., Peters, J.W.
Deposit date:2010-11-18
Release date:2011-01-05
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:FAD binding by ApbE protein from Salmonella enterica: a new class of FAD-binding proteins.
J.Bacteriol., 193, 2011
4KZ2
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CRYSTAL STRUCTURE OF PHI29 PRNA 3WJ CORE
Descriptor:phi29 pRNA 3WJ core RNA 18 mer, phi29 pRNA 3WJ core RNA 20 mer, phi29 pRNA 3WJ core RNA 16 mer, ...
Authors:Zhang, H., Endrizzi, J.A., Shu, Y., Haque, F., Sauter, C., Guo, P., Chi, Y.-I.
Deposit date:2013-05-29
Release date:2013-10-16
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal structure of 3WJ core revealing divalent ion-promoted thermostability and assembly of the Phi29 hexameric motor pRNA.
Rna, 19, 2013
5DUI
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IDENTIFICATION OF A NEW FOXO1 BINDING SITE THAT PRECLUDES CREB BINDING AT THE GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT GENE PROMOTER
Descriptor:Forkhead box protein O1, DNA (5'-D(*TP*TP*TP*TP*CP*TP*AP*TP*TP*TP*TP*AP*CP*GP*TP*AP*AP*AP*TP*CP*A)-3'), DNA (5'-D(*AP*TP*GP*AP*TP*TP*TP*AP*CP*GP*TP*AP*AP*AP*AP*TP*AP*GP*AP*AP*A)-3')
Authors:Singh, P., Endrizzi, J.A., Chi, Y.-I.
Deposit date:2015-09-18
Release date:2016-09-21
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (2.306 Å)
Cite:Crystal structures reveal a new and novel FoxO1 binding site within the human glucose-6-phosphatase catalytic subunit 1 gene promoter.
J. Struct. Biol., 198, 2017
5TKV
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X-RAY CRYSTAL STRUCTURE OF THE "CLOSED" CONFORMATION OF CTP-INHIBITED E. COLI CYTIDINE TRIPHOSPHATE (CTP) SYNTHETASE
Descriptor:CTP synthase, GLUTAMINE, SULFATE ION, ...
Authors:Baldwin, E.P., Endrizzi, J.A.
Deposit date:2016-10-07
Release date:2017-04-26
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Human CTP synthase filament structure reveals the active enzyme conformation.
Nat. Struct. Mol. Biol., 24, 2017
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