Identification of a new FoxO1 binding site that precludes CREB binding at the glucose-6-phosphatase catalytic subunit gene promoter

Summary for 5DUI

DescriptorForkhead box protein O1, DNA (5'-D(*TP*TP*TP*TP*CP*TP*AP*TP*TP*TP*TP*AP*CP*GP*TP*AP*AP*AP*TP*CP*A)-3'), DNA (5'-D(*AP*TP*GP*AP*TP*TP*TP*AP*CP*GP*TP*AP*AP*AP*AP*TP*AP*GP*AP*AP*A)-3'), ... (4 entities in total)
Functional Keywordstranscription factor, winged helix, dna binding, protein-dna complex, diabetes, transcription regulation, transcription-dna complex, transcription/dna
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm  Q12778
Total number of polymer chains4
Total molecular weight37771.29
Singh, P.,Endrizzi, J.A.,Chi, Y.-I. (deposition date: 2015-09-18, release date: 2016-09-21, Last modification date: 2017-12-20)
Primary citation
Singh, P.,Han, E.H.,Endrizzi, J.A.,O'Brien, R.M.,Chi, Y.I.
Crystal structures reveal a new and novel FoxO1 binding site within the human glucose-6-phosphatase catalytic subunit 1 gene promoter.
J. Struct. Biol., 198:54-64, 2017
PubMed: 28223045 (PDB entries with the same primary citation)
DOI: 10.1016/j.jsb.2017.02.006
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24330.6%1.3%10.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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