Author results

5E2C
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CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF CYTOPLASMIC PEPTIDASE PEPQ FROM MYCOBACTERIUM TUBERCULOSIS H37RV
Descriptor:Xaa-Pro dipeptidase
Authors:Chang, C., Endres, L., Endres, M., SACCHETTINI, J., JOACHIMIAK, A., Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI)
Deposit date:2015-09-30
Release date:2015-10-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of N-terminal domain of cytoplasmic peptidase PepQ from Mycobacterium tuberculosis H37Rv
To Be Published
4NPX
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STRUCTURE OF HYPOTHETICAL PROTEIN CJ0539 FROM CAMPYLOBACTER JEJUNI
Descriptor:Putative uncharacterized protein
Authors:Filippova, E.V., Minasov, G., Shuvalova, L., Kiryukhina, O., Adkins, J.N., Endres, M., Nissen, M., Konkel, M., Joachimiak, A., Anderson, W.F., Midwest Center for Structural Genomics (MCSG), Program for the Characterization of Secreted Effector Proteins (PCSEP)
Deposit date:2013-11-22
Release date:2014-01-01
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structure of hypothetical protein Cj0539 from Campylobacter jejuni
To be Published
5BMO
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LNMX PROTEIN, A PUTATIVE GLCNAC-PI DE-N-ACETYLASE FROM STREPTOMYCES ATROOLIVACEUS
Descriptor:Putative uncharacterized protein LnmX, POTASSIUM ION, ACETATE ION
Authors:Osipiuk, J., Hatzos-Skintges, C., Cuff, M., Endres, M., Babnigg, G., Lohman, J., Ma, M., Rudolf, J., Chang, C.-Y., Shen, B., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-05-22
Release date:2015-06-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:LnmX protein, a putative GlcNAc-PI de-N-acetylase from Streptomyces atroolivaceus.
to be published
6QKY
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TRYPTOPHAN SYNTHASE SUBUNIT ALPHA FROM STREPTOCOCCUS PNEUMONIAE WITH 3D DOMAIN SWAP IN THE CORE OF TIM BARREL
Descriptor:Tryptophan synthase alpha chain, GLYCEROL, ACETIC ACID, ...
Authors:Michalska, K., Kowiel, M., Bigelow, L., Endres, M., Gilski, M., Jaskolski, M., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2019-01-30
Release date:2019-03-27
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:3D domain swapping in the TIM barrel of the alpha subunit of Streptococcus pneumoniae tryptophan synthase
To be published
4JWO
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THE CRYSTAL STRUCTURE OF A POSSIBLE PHOSPHATE BINDING PROTEIN FROM PLANCTOMYCES LIMNOPHILUS DSM 3776
Descriptor:Phosphate binding protein, SULFATE ION, FORMIC ACID, ...
Authors:Tan, K., Gu, M., Endres, M., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2013-03-27
Release date:2013-04-24
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:The crystal structure of a possible phosphate binding protein from Planctomyces limnophilus DSM 3776
To be Published
4OPE
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STREPTOMCYES ALBUS JA3453 OXAZOLOMYCIN KETOSYNTHASE DOMAIN OZMH KS7
Descriptor:NRPS/PKS, NITRATE ION
Authors:Osipiuk, J., Mack, J., Endres, M., Babnigg, G., Bingman, C.A., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-02-05
Release date:2014-02-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
4OPF
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STREPTOMCYES ALBUS JA3453 OXAZOLOMYCIN KETOSYNTHASE DOMAIN OZMH KS8
Descriptor:NRPS/PKS
Authors:Osipiuk, J., Bigelow, L., Endres, M., Babnigg, G., Bingman, C.A., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-02-05
Release date:2014-02-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
4OVY
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CRYSTAL STRUCTURE OF HALOACID DEHALOGENASE DOMAIN PROTEIN HYDROLASE FROM PLANCTOMYCES LIMNOPHILUS DSM 3776
Descriptor:Haloacid dehalogenase domain protein hydrolase, CITRIC ACID, 1,2-ETHANEDIOL, ...
Authors:Chang, C., Gu, M., Endres, M., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2014-01-24
Release date:2014-02-05
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of Haloacid dehalogenase domain protein hydrolase from Planctomyces limnophilus DSM 3776
To be published
4QYR
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STREPTOMYCES PLATENSIS ISOMIGRASTATIN KETOSYNTHASE DOMAIN MGSE KS3
Descriptor:AT-less polyketide synthase, GLYCEROL, ACETIC ACID, ...
Authors:Kim, Y., Li, H., Endres, M., Babnigg, J., Bingman, C.A., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-07-25
Release date:2014-08-20
Last modified:2016-12-07
Method:X-RAY DIFFRACTION (2.902 Å)
Cite:Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
4TKT
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STREPTOMYCES PLATENSIS ISOMIGRASTATIN KETOSYNTHASE DOMAIN MGSF KS6
Descriptor:AT-less polyketide synthase, CHLORIDE ION, SULFATE ION, ...
Authors:Chang, C., Li, H., Endres, M., Bingman, C., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-05-27
Release date:2014-06-11
Last modified:2016-11-02
Method:X-RAY DIFFRACTION (2.4289 Å)
Cite:Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
4WKY
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STREPTOMCYES ALBUS JA3453 OXAZOLOMYCIN KETOSYNTHASE DOMAIN OZMN KS2
Descriptor:Beta-ketoacyl synthase, SULFATE ION, GLYCEROL, ...
Authors:Cuff, M.E., Mack, J.C., Endres, M., Babnigg, G., Bingman, C.A., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-10-03
Release date:2014-10-29
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
4X2R
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CRYSTAL STRUCTURE OF PRIA FROM ACTINOMYCES UROGENITALIS
Descriptor:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, PHOSPHATE ION, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID
Authors:MICHALSKA, K., VERDUZCO-CASTRO, E.A., ENDRES, M., BARONA-GOMEZ, F., JOACHIMIAK, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2014-11-26
Release date:2014-12-24
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Evolution of substrate specificity in a retained enzyme driven by gene loss.
Elife, 6, 2017
4XXT
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CRYSTAL STRUCTURE OF FUSED ZN-DEPENDENT AMIDASE/PEPTIDASE/PEPTODOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN FROM CLOSTRIDIUM ACETOBUTYLICUM ATCC 824
Descriptor:Fusion of predicted Zn-dependent amidase/peptidase (Cell wall hydrolase/DD-carboxypeptidase family) and uncharacterized domain of ErfK family peptodoglycan-binding domain, 1,2-ETHANEDIOL, ACETATE ION, ...
Authors:Chang, C., Cuff, M., Joachimiak, G., Endres, M., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2015-01-30
Release date:2015-02-18
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Crystal structure of Fused Zn-dependent amidase/peptidase/peptodoglycan-binding domain-containing protein from from Clostridium acetobutylicum ATCC 824
To Be Published
4ZDN
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STREPTOMYCES PLATENSIS ISOMIGRASTATIN KETOSYNTHASE DOMAIN MGSF KS4
Descriptor:AT-less polyketide synthase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION
Authors:Chang, C., Li, H., Endres, M., Bingman, C., Yennamalli, R., Lohman, J.R., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-04-17
Release date:2015-05-13
Last modified:2016-11-02
Method:X-RAY DIFFRACTION (2.509 Å)
Cite:Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZTK
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TRANSPEPTIDASE DOMAIN OF FTSI4 D,D-TRANSPEPTIDASE FROM LEGIONELLA PNEUMOPHILA.
Descriptor:Cell division protein FtsI/penicillin binding protein 2, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID
Authors:CUFF, M., OSIPIUK, J., WU, R., ENDRES, M., JOACHIMIAK, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2015-05-14
Release date:2015-05-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.104 Å)
Cite:Transpeptidase domain of FtsI4 D,D-transpeptidase from Legionella pneumophila.
to be published
5BP8
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ENT-COPALYL DIPHOSPHATE SYNTHASE FROM STREPTOMYCES PLATENSIS
Descriptor:Ent-copalyl diphosphate synthase, SULFATE ION, 1,2-ETHANEDIOL
Authors:Osipiuk, J., Hatzos-Skintges, C., Endres, M., Babnigg, G., Rudolf, J.D., Ma, M., Chang, C.-Y., Shen, B., Joachimiak, A., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG)
Deposit date:2015-05-27
Release date:2015-06-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase.
J.Am.Chem.Soc., 138, 2016
5C0P
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THE CRYSTAL STRUCTURE OF ENDO-ARABINASE FROM BACTEROIDES THETAIOTAOMICRON VPI-5482
Descriptor:Endo-arabinase, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Tan, K., Cuff, M., Joachimiak, G., Endres, M., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2015-06-12
Release date:2015-07-01
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.532 Å)
Cite:The crystal structure of endo-arabinase from Bacteroides thetaiotaomicron VPI-5482
To Be Published
5CR9
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CRYSTAL STRUCTURE OF ABC-TYPE FE3+-HYDROXAMATE TRANSPORT SYSTEM FROM SACCHAROMONOSPORA VIRIDIS DSM 43017
Descriptor:ABC-type Fe3+-hydroxamate transport system, periplasmic component, MANGANESE (II) ION, ...
Authors:Nocek, B., Cuff, M., Mack, J., Endres, M., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2015-07-22
Release date:2015-08-12
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of ABC-type Fe3+-hydroxamate transport system from Saccharomonospora viridis DSM 43017
To Be Published
5E7Q
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ACYL-COA SYNTHETASE PTMA2 FROM STREPTOMYCES PLATENSIS
Descriptor:acyl-CoA synthetase, SULFATE ION, GLYCEROL
Authors:Osipiuk, J., Cuff, M.E., Hatzos-Skintges, C., Endres, M., Babnigg, G., Rudolf, J., Ma, M., Chang, C.Y., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-10-12
Release date:2015-10-21
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme.
Nat. Chem. Biol., 14, 2018
5F1P
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CRYSTAL STRUCTURE OF DEHYDROGENASE FROM STREPTOMYCES PLATENSIS
Descriptor:PtmO8
Authors:Kim, Y., Li, H., Endres, M., Babnigg, G., Rudolf, J., Ma, M., Chang, C.-Y., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-11-30
Release date:2015-12-30
Last modified:2017-02-22
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Crystal Structure of a Dehydrogenase, PtmO8, from Streptomyces platensis
To Be Published
5IXP
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CRYSTAL STRUCTURE OF EXTRACELLULAR SOLUTE-BINDING PROTEIN FAMILY 1
Descriptor:Extracellular solute-binding protein family 1, FORMIC ACID
Authors:Chang, C., Cuff, M., Chhor, G., Endres, M., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2016-03-23
Release date:2016-03-30
Last modified:2016-08-17
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Crystal structure of Extracellular solute-binding protein family 1
To Be Published
5J7M
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CRYSTAL STRUCTURE OF CUPIN 2 CONSERVED BARREL DOMAIN PROTEIN FROM KRIBBELLA FLAVIDA DSM 17836
Descriptor:Cupin 2 conserved barrel domain protein, ETHANOL, NICKEL (II) ION, ...
Authors:Chang, C., Cuff, M., Chhor, G., Endres, M., Joachimiak, A.
Deposit date:2016-04-06
Release date:2016-04-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Crystal structure of Cupin 2 conserved barrel domain protein from Kribbella flavida DSM 17836
To Be Published
5UPQ
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ACYL-COA SYNTHETASE PTMA2 FROM STREPTOMYCES PLATENSIS IN COMPLEX WITH SBNP465 LIGAND
Descriptor:Acyl-CoA synthetase PtmA2, 5'-O-[(R)-{[(7beta,8alpha,9beta,10alpha,13alpha,16beta)-7,16-dihydroxy-18-oxokauran-18-yl]oxy}(hydroxy)phosphoryl]adenosine, SULFATE ION, ...
Authors:Osipiuk, J., Hatzos-Skintges, C., Endres, M., Babnigg, G., Rudolf, J.D., Chang, C.Y., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2017-02-03
Release date:2017-02-22
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme.
Nat. Chem. Biol., 14, 2018
5UPS
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ACYL-COA SYNTHETASE PTMA2 FROM STREPTOMYCES PLATENSIS IN COMPLEX WITH SBNP663 LIGAND
Descriptor:Acyl-CoA synthetase PtmA2, 5'-O-[(R)-hydroxy{[(7beta,8alpha,9beta,10alpha,11beta,13alpha)-7-hydroxy-19-oxo-11,16-epoxykauran-19-yl]oxy}phosphoryl]adenosine, SODIUM ION, ...
Authors:Osipiuk, J., Hatzos-Skintges, C., Endres, M., Babnigg, G., Rudolf, J.D., Chang, C.-Y., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2017-02-03
Release date:2017-02-22
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme.
Nat. Chem. Biol., 14, 2018
5UPT
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ACYL-COA SYNTHETASE PTMA2 FROM STREPTOMYCES PLATENSIS IN COMPLEX WITH SBNP468 LIGAND
Descriptor:Acyl-CoA synthetase PtmA2, (7alpha,8alpha,10alpha,13alpha)-7,16-dihydroxykauran-18-oic acid, SULFATE ION, ...
Authors:Osipiuk, J., Hatzos-Skintges, C., Endres, M., Babnigg, G., Rudolf, J.D., Chang, C.Y., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2017-02-03
Release date:2017-02-22
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme.
Nat. Chem. Biol., 14, 2018