7UV5

The crystal structure of Papain-Like Protease of SARS CoV-2, C111S/D286N mutant, in complex with a Lys48-linked di-ubiquitin

Summary for 7UV5

Entry DOI	10.2210/pdb7uv5/pdb
Related	7rbr
Descriptor	Papain-like protease nsp3, Ubiquitin, ZINC ION, ... (6 entities in total)
Functional Keywords	covid-19, coronavirus, sars, cov-2, papain-like protease, ubiquitin, idp51000, idp52003, center for structural genomics of infectious diseases, csgid, hydrolase
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	3
Total formula weight	53422.07
Authors	Osipiuk, J.,Tesar, C.,Endres, M.,Lanham, B.T.,Wydorski, P.,Fushman, D.,Joachimiak, L.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2022-04-29, release date: 2022-05-11, Last modification date: 2023-10-25)
Primary citation	Wydorski, P.M.,Osipiuk, J.,Lanham, B.T.,Tesar, C.,Endres, M.,Engle, E.,Jedrzejczak, R.,Mullapudi, V.,Michalska, K.,Fidelis, K.,Fushman, D.,Joachimiak, A.,Joachimiak, L.A. Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin. Nat Commun, 14:2366-2366, 2023 Cited by PubMed: 37185902 DOI: 10.1038/s41467-023-38031-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation