7UV5
The crystal structure of Papain-Like Protease of SARS CoV-2, C111S/D286N mutant, in complex with a Lys48-linked di-ubiquitin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Papain-like protease nsp3 | polymer | 318 | 35926.7 | 1 | UniProt (P0DTC1) Pfam (PF08715) UniProt (by SIFTS) (P0DTD1) | Severe acute respiratory syndrome coronavirus 2 | Non-structural protein 3,nsp3,PL2-PRO,Papain-like proteinase,PL-PRO |
| 2 | B (B) | Ubiquitin | polymer | 76 | 8576.8 | 1 | UniProt (P0CG48) Pfam (PF00240) | Homo sapiens (human) | |
| 3 | C (C) | Ubiquitin | polymer | 76 | 8604.8 | 1 | UniProt (P0CG47) Pfam (PF00240) | Homo sapiens (human) | |
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E, F, G, H (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 6 | I, J, K (A, B, C) | water | water | 18.0 | 355 | Chemie (HOH) |
Sequence modifications
A: 1 - 315 (UniProt: P0DTC1)
C: 1 - 76 (UniProt: P0CG47)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Ser 111 | Cys 1674 | engineered mutation |
| Asn 286 | Asp 1849 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Arg 48 | Lys 48 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 53108.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 313.7 | |
| All* | Total formula weight | 53422.1 |
