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3AQA
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BU of 3aqa by Molmil
Crystal structure of the human BRD2 BD1 bromodomain in complex with a BRD2-interactive compound, BIC1
Descriptor: 1-[2-(1H-benzimidazol-2-ylsulfanyl)ethyl]-3-methyl-1,3-dihydro-2H-benzimidazole-2-thione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Bromodomain-containing protein 2
Authors:Umehara, T, Nakamura, Y, Terada, T, Shirouzu, M, Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2010-10-27
Release date:2011-05-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Real-Time Imaging of Histone H4K12-Specific Acetylation Determines the Modes of Action of Histone Deacetylase and Bromodomain Inhibitors
Chem.Biol., 18, 2011
3WMY
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BU of 3wmy by Molmil
Crystal Structure of Streptomyces coelicolor alpha-L-arabinofuranosidase
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, CHLORIDE ION, ...
Authors:Fujimoto, Z, Maehara, T, Ichinose, H, Michikawa, M, Harazono, K, Kaneko, S.
Deposit date:2013-11-29
Release date:2014-02-05
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure and characterization of the glycoside hydrolase family 62 alpha-L-arabinofuranosidase from Streptomyces coelicolor
J.Biol.Chem., 289, 2014
3WMZ
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BU of 3wmz by Molmil
Crystal Structure of Streptomyces coelicolor alpha-L-arabinofuranosidase ethylmercury derivative
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ETHYL MERCURY ION, ...
Authors:Fujimoto, Z, Maehara, T, Ichinose, H, Michikawa, M, Harazono, K, Kaneko, S.
Deposit date:2013-11-29
Release date:2014-02-05
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure and characterization of the glycoside hydrolase family 62 alpha-L-arabinofuranosidase from Streptomyces coelicolor
J.Biol.Chem., 289, 2014
3WN1
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BU of 3wn1 by Molmil
Crystal Structure of Streptomyces coelicolor alpha-L-arabinofuranosidase in complex with xylotriose
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, CHLORIDE ION, ...
Authors:Fujimoto, Z, Maehara, T, Ichinose, H, Michikawa, M, Harazono, K, Kaneko, S.
Deposit date:2013-11-29
Release date:2014-02-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure and characterization of the glycoside hydrolase family 62 alpha-L-arabinofuranosidase from Streptomyces coelicolor
J.Biol.Chem., 289, 2014
3WN0
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BU of 3wn0 by Molmil
Crystal Structure of Streptomyces coelicolor alpha-L-arabinofuranosidase in complex with L-arabinose
Descriptor: CALCIUM ION, CHLORIDE ION, CITRIC ACID, ...
Authors:Fujimoto, Z, Maehara, T, Ichinose, H, Michikawa, M, Harazono, K, Kaneko, S.
Deposit date:2013-11-29
Release date:2014-02-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure and characterization of the glycoside hydrolase family 62 alpha-L-arabinofuranosidase from Streptomyces coelicolor
J.Biol.Chem., 289, 2014
3WN2
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BU of 3wn2 by Molmil
Crystal Structure of Streptomyces coelicolor alpha-L-arabinofuranosidase in complex with xylohexaose
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, CHLORIDE ION, ...
Authors:Fujimoto, Z, Maehara, T, Ichinose, H, Michikawa, M, Harazono, K, Kaneko, S.
Deposit date:2013-11-29
Release date:2014-02-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure and characterization of the glycoside hydrolase family 62 alpha-L-arabinofuranosidase from Streptomyces coelicolor
J.Biol.Chem., 289, 2014
2DVS
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BU of 2dvs by Molmil
Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide
Descriptor: bromodomain-containing protein 2, histone H4
Authors:Nakamura, Y, Umehara, T, Shirouzu, M, Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-08-01
Release date:2007-08-07
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain.
J.Biol.Chem., 285, 2010
2DVR
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BU of 2dvr by Molmil
Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide
Descriptor: bromodomain-containing protein 2, histone H4
Authors:Nakamura, Y, Umehara, T, Shirouzu, M, Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-08-01
Release date:2007-08-07
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain.
J.Biol.Chem., 285, 2010
2DVQ
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BU of 2dvq by Molmil
Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide
Descriptor: Bromodomain-containing protein 2, histone H4
Authors:Nakamura, Y, Umehara, T, Shirouzu, M, Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-08-01
Release date:2007-08-07
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain.
J.Biol.Chem., 285, 2010
6RAV
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BU of 6rav by Molmil
Complement factor B protease domain in complex with the reversible inhibitor 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid
Descriptor: 4-[(2~{S},4~{S})-4-ethoxy-1-[(5-methoxy-7-methyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic acid, Complement factor B, SULFATE ION, ...
Authors:Adams, C.M, Sellner, H, Ehara, T, Mac Sweeney, A, Crowley, M, Anderson, K, Karki, R, Mainolfi, N, Valeur, E, Sirockin, F, Gerhartz, B, Erbel, P, Hughes, N, Smith, T.M, Cumin, F, Argikar, U, Mogi, M, Sedrani, R, Wiesmann, C, Jaffee, B, Maibaum, J, Flohr, S, Harrison, R, Eder, J.
Deposit date:2019-04-08
Release date:2019-04-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Proc.Natl.Acad.Sci.USA, 116, 2019
6T8W
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BU of 6t8w by Molmil
Complement factor B in complex with (-)-4-(1-((5,7-Dimethyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid
Descriptor: 5,7-dimethyl-4-[[(2~{S})-2-phenylpiperidin-1-yl]methyl]-1~{H}-indole, Complement factor B, SULFATE ION, ...
Authors:Mainolfi, N, Ehara, T, Karki, R.G, Anderson, K, Sweeney, A.M, Wiesmann, C, Adams, C, Mainolfi, N, Liao, S.M, Argikar, U.A, Jendza, K, Zhang, C, Powers, J, Klosowski, D.W, Crowley, M, Kawanami, T, Ding, J, April, M, Forster, C, Wu, M.S, Capparelli, M, Ramqaj, R, Solovay, C, Cumin, F, Smith, T.M, Ferrara, L, Lee, W, Long, D, Prentiss, M, Erkenez, A.D, Yang, L, Fang, L, Sellner, H, Sirockin, F, Valeur, E, Erbel, P, Ramage, P, Gerhartz, B, Schubart, A, Flohr, S, Gradoux, N, Feifel, R, Vogg, B, Wiesmann, C, Maibaum, J, Eder, J, Sedrani, R, Harrison, R.A, Mogi, M, Jaffee, B.D, Adams, C.M.
Deposit date:2019-10-25
Release date:2020-03-04
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J.Med.Chem., 63, 2020
6T8U
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BU of 6t8u by Molmil
Complement factor B in complex with 5-Bromo-3-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-7-methyl-1H-indol-4-amine
Descriptor: 5-bromanyl-3-chloranyl-~{N}-(1~{H}-imidazol-2-yl)-7-methyl-1~{H}-indol-4-amine, Complement factor B, SULFATE ION
Authors:Mainolfi, N, Ehara, T, Karki, R.G, Anderson, K, Mac Sweeney, A, Wiesmann, C, Adams, C, Liao, S.-M, Argikar, U.A, Jendza, K, Zhang, C, Powers, J, Klosowski, D.W, Crowley, M, Kawanami, T, Ding, J, April, M, Forster, C, Serrano-Wu, M, Capparelli, M, Ramqaj, R, Solovay, C, Cumin, F, Smith, T.M, Ferrara, L, Lee, W, Long, D, Prentiss, M, De Erkenez, A, Yang, L, Fang, L, Sellner, H, Sirockin, F, Valeur, E, Erbel, P, Ramage, P, Gerhartz, B, Schubart, A, Flohr, S, Gradoux, N, Feifel, R, Vogg, B, Maibaum, J, Eder, J, Sedrani, R, Harrison, R.A, Mogi, M, Jaffee, B.D, Adams, C.M.
Deposit date:2019-10-25
Release date:2020-03-04
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J.Med.Chem., 63, 2020
6T8V
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BU of 6t8v by Molmil
Complement factor B in complex with (S)-5,7-Dimethyl-4-((2-phenylpiperidin-1-yl)methyl)-1H-indole
Descriptor: 4-[(2~{S})-1-[(5,7-dimethyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic acid, Complement factor B, SULFATE ION, ...
Authors:Mainolfi, N, Ehara, T, Karki, R.G, Anderson, K, Mac Sweeney, A, Wiesmann, C, Adams, C, Mainolfi, N, Liao, S.-M, Argikar, U.A, Jendza, K, Zhang, C, Powers, J, Klosowski, D.W, Crowley, M, Kawanami, T, Ding, J, April, M, Forster, C, Serrano-Wu, M, Capparelli, M, Ramqaj, R, Solovay, C, Cumin, F, Smith, T.M, Ferrara, L, Lee, W, Long, D, Prentiss, M, De Erkenez, A, Yang, L, Fang, L, Sellner, H, Sirockin, F, Valeur, E, Erbel, P, Ramage, P, Gerhartz, B, Schubart, A, Flohr, S, Gradoux, N, Feifel, R, Vogg, B, Wiesmann, C, Maibaum, J, Eder, J, Sedrani, R, Harrison, R.A, Mogi, M, Jaffee, B.D, Adams, C.M.
Deposit date:2019-10-25
Release date:2020-03-04
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J.Med.Chem., 63, 2020
6QSX
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BU of 6qsx by Molmil
Complement factor B protease domain in complex with the reversible inhibitor ((2S,4S)-1-((5,7-dimethyl-1H-indol-4-yl)methyl)-4-methoxypiperidin-2-yl)methanol.
Descriptor: Complement factor B, SULFATE ION, ZINC ION, ...
Authors:Adams, C.M, Sellner, H, Ehara, T, Mac Sweeney, A, Crowley, M, Anderson, K, Karki, R, Mainolfi, N, Valeur, E, Sirockin, F, Gerhartz, B, Erbel, P, Hughes, N, Smith, T.M, Cumin, F, Argikar, U, Mogi, M, Sedrani, R, Wiesmann, C, Jaffee, B, Maibaum, J, Flohr, S, Harrison, R, Eder, J.
Deposit date:2019-02-22
Release date:2019-03-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Proc.Natl.Acad.Sci.USA, 116, 2019
6QSW
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BU of 6qsw by Molmil
Complement factor B protease domain in complex with the reversible inhibitor N-(2-bromo-4-methylnaphthalen-1-yl)-4,5-dihydro-1H-imidazol-2-amine.
Descriptor: Complement factor B, SULFATE ION, ~{N}-(2-bromanyl-4-methyl-naphthalen-1-yl)-4,5-dihydro-1~{H}-imidazol-2-amine
Authors:Adams, C.M, Sellner, H, Ehara, T, Mac Sweeney, A, Crowley, M, Anderson, K, Karki, R, Mainolfi, N, Valeur, E, Sirockin, F, Gerhartz, B, Erbel, P, Hughes, N, Smith, T.M, Cumin, F, Argikar, U, Mogi, M, Sedrani, R, Wiesmann, C, Jaffee, B, Maibaum, J, Flohr, S, Harrison, R, Eder, J.
Deposit date:2019-02-22
Release date:2019-03-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Proc.Natl.Acad.Sci.USA, 116, 2019
5X51
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BU of 5x51 by Molmil
RNA Polymerase II from Komagataella Pastoris (Type-3 crystal)
Descriptor: DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, RNA polymerase II subunit, ...
Authors:Ehara, H, Umehara, T, Sekine, S, Yokoyama, S.
Deposit date:2017-02-14
Release date:2017-05-17
Method:X-RAY DIFFRACTION (6.996 Å)
Cite:Crystal structure of RNA polymerase II from Komagataella pastoris
Biochem. Biophys. Res. Commun., 487, 2017
5X50
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BU of 5x50 by Molmil
RNA Polymerase II from Komagataella Pastoris (Type-2 crystal)
Descriptor: DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, RNA polymerase II subunit, ...
Authors:Ehara, H, Umehara, T, Sekine, S, Yokoyama, S.
Deposit date:2017-02-14
Release date:2017-05-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (4.293 Å)
Cite:Crystal structure of RNA polymerase II from Komagataella pastoris
Biochem. Biophys. Res. Commun., 487, 2017
5X4Z
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BU of 5x4z by Molmil
RNA Polymerase II from Komagataella Pastoris (Type-1 crystal)
Descriptor: DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, RNA polymerase II subunit, ...
Authors:Ehara, H, Umehara, T, Sekine, S, Yokoyama, S.
Deposit date:2017-02-14
Release date:2017-05-17
Method:X-RAY DIFFRACTION (7.8 Å)
Cite:Crystal structure of RNA polymerase II from Komagataella pastoris
Biochem. Biophys. Res. Commun., 487, 2017
5X17
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BU of 5x17 by Molmil
Crystal structure of murine CK1d in complex with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Casein kinase I isoform delta, SULFATE ION
Authors:Kikuchi, M, Shinohara, Y, Ueda, H.R, Umehara, T.
Deposit date:2017-01-25
Release date:2017-10-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock
Mol. Cell, 67, 2017
8IIY
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BU of 8iiy by Molmil
Crystal structure of MBP fused GAS41 YEATS domain in complex with H3K14ac peptide
Descriptor: GLYCEROL, Histone H3.1, Maltodextrin-binding protein,YEATS domain-containing protein 4, ...
Authors:Kikuchi, M, Umehara, T.
Deposit date:2023-02-24
Release date:2023-11-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain.
Proc.Natl.Acad.Sci.USA, 120, 2023
8IIZ
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BU of 8iiz by Molmil
Crystal structure of MBP fused GAS41 YEATS domain in complex with H3K27ac peptide
Descriptor: GLYCEROL, Histone H3.1, Maltodextrin-binding protein,YEATS domain-containing protein 4, ...
Authors:Kikuchi, M, Umehara, T.
Deposit date:2023-02-24
Release date:2023-11-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain.
Proc.Natl.Acad.Sci.USA, 120, 2023
8IJ0
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BU of 8ij0 by Molmil
Crystal structure of GAS41 YEATS domain in complex with H3K9ac peptide
Descriptor: GLYCEROL, Histone H3.1, PENTAETHYLENE GLYCOL, ...
Authors:Kikuchi, M, Umehara, T.
Deposit date:2023-02-24
Release date:2023-11-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain.
Proc.Natl.Acad.Sci.USA, 120, 2023
2RR6
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BU of 2rr6 by Molmil
Solution structure of the leucine rich repeat of human acidic leucine-rich nuclear phosphoprotein 32 family member B
Descriptor: Acidic leucine-rich nuclear phosphoprotein 32 family member B
Authors:Tochio, N, Umehara, T, Tsuda, K, Koshiba, S, Harada, T, Watanabe, S, Tanaka, A, Kigawa, T, Yokoyama, S.
Deposit date:2010-05-25
Release date:2010-06-09
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution structure of histone chaperone ANP32B: interaction with core histones H3-H4 through its acidic concave domain.
J.Mol.Biol., 401, 2010
2RV0
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BU of 2rv0 by Molmil
Solution structures of the DNA-binding domain (ZF12) of immune-related zinc-finger protein ZFAT
Descriptor: ZINC ION, Zinc finger protein ZFAT
Authors:Tochio, N, Umehara, T, Kigawa, T, Yokoyama, S.
Deposit date:2015-01-26
Release date:2015-04-08
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT
J.Struct.Funct.Genom., 16, 2015
2RV6
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BU of 2rv6 by Molmil
Solution structures of the DNA-binding domains (ZF2-ZF3-ZF4) of immune-related zinc-finger protein ZFAT
Descriptor: ZINC ION, Zinc finger protein ZFAT
Authors:Tochio, N, Umehara, T, Kigawa, T, Yokoyama, S.
Deposit date:2015-01-26
Release date:2015-04-08
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT
J.Struct.Funct.Genom., 16, 2015

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