Author results

6MLC
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PHD6 DOMAIN OF MLL3 IN COMPLEX WITH HISTONE H4
Descriptor:Histone-lysine N-methyltransferase 2C, Histone H4, ZINC ION, ...
Authors:Dong, A., Liu, Y., Qin, S., Lei, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-09-27
Release date:2018-10-24
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.
Nat Commun, 10, 2019
6MF9
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CRYSTAL STRUCTURE OF CGD4-650 WITH COMPOUND BI2536
Descriptor:ZnKn (C2HC)+Athook+bromo domain protein, Taf250, transcription initiation factor IID, ...
Authors:Dong, A., Lin, Y.L., Hou, D., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Vedadi, M., Hui, R., Structural Genomics Consortium (SGC)
Deposit date:2018-09-10
Release date:2018-10-10
Method:X-RAY DIFFRACTION (2.037 Å)
Cite:Crystal structure of CGD4-650 with compound BI2536
to be published
6MEW
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RFXANK ANKYRIN REPEATS IN COMPLEX WITH A RFX7 PEPTIDE
Descriptor:DNA-binding protein RFXANK, RFX7 peptide, UNKNOWN ATOM OR ION
Authors:Tempel, W., Xu, C., Dong, A., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-09-07
Release date:2018-10-03
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:RFXANK ankyrin repeats in complex with a RFX7 peptide
to be published
5Y53
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CRYSTAL STRUCTURE OF AL2 PAL DOMAIN IN COMPLEX WITH ATBMI1B BINDING SITE
Descriptor:PHD finger protein ALFIN-LIKE 2, AtBMI1b binding site
Authors:Peng, L., Wang, L.L., Huang, Y.
Deposit date:2017-08-07
Release date:2018-08-15
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.598 Å)
Cite:Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch
J. Mol. Biol., 430, 2018
5Y21
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CRYSTAL STRUCTURE OF AL2 PAL DOMAIN IN COMPLEX WITH ATRING1A PROXIMAL SITE
Descriptor:PHD finger protein ALFIN-LIKE 2, AtRing1a proximal binding site peptide
Authors:Peng, L., Wang, L.L., Huang, Y.
Deposit date:2017-07-22
Release date:2018-07-25
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.769 Å)
Cite:Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch
J. Mol. Biol., 430, 2018
6DVR
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CRYSTAL STRUCTURE OF HUMAN CARM1 WITH (R)-SKI-72
Descriptor:Histone-arginine methyltransferase CARM1, (2R,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-methoxyphenyl)ethyl]hexanamide (non-preferred name), 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ...
Authors:Dong, A., Zeng, H., Hutchinson, A., Seitova, A., Luo, M., Cai, X.C., Ke, W., Wang, J., Shi, C., Zheng, W., Lee, J.P., Ibanez, G., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2018-06-25
Release date:2018-07-25
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Crystal structure of human CARM1 with (R)-SKI-72
to be published
5WCH
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CRYSTAL STRUCTURE OF A PEPTIDASE
Descriptor:Probable ubiquitin carboxyl-terminal hydrolase FAF-X, ZINC ION, UNKNOWN ATOM OR ION
Authors:Dong, A., Zhang, Q., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-06-30
Release date:2018-07-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a peptidase
to be published
5XVJ
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CRYSTAL STRUCTURE OF AL7 PAL DOMAIN
Descriptor:PHD finger protein ALFIN-LIKE 7, SULFATE ION
Authors:Peng, L., Wang, L.L., Huang, Y.
Deposit date:2017-06-28
Release date:2018-07-04
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch
J. Mol. Biol., 430, 2018
5XVL
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CRYSTAL STRUCTURE OF AL2 PAL DOMAIN
Descriptor:PHD finger protein ALFIN-LIKE 2, SULFATE ION
Authors:Peng, L., Wang, L.L., Huang, Y.
Deposit date:2017-06-28
Release date:2018-07-04
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.629 Å)
Cite:Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch
J. Mol. Biol., 430, 2018
5XVW
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CRYSTAL STRUCTURE OF AL2 PAL DOMAIN IN COMPLEX WITH ATRING1A DISTAL SITE
Descriptor:PHD finger protein ALFIN-LIKE 2, AtRing1a distal binding site
Authors:Peng, L., Wang, L.L., Huang, Y.
Deposit date:2017-06-28
Release date:2018-07-04
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch
J. Mol. Biol., 430, 2018
6CVZ
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CRYSTAL STRUCTURE OF THE WD40-REPEAT OF RFWD3
Descriptor:E3 ubiquitin-protein ligase RFWD3, MAGNESIUM ION
Authors:DONG, A., LOPPNAU, P., SEITOVA, A., HUTCHINSON, A., TEMPEL, W., WEI, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., TONG, Y., Structural Genomics Consortium (SGC)
Deposit date:2018-03-29
Release date:2018-06-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the WD40-repeat of RFWD3
to be published
6DK3
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HUMAN MITOCHONDRIAL SERINE HYDROXYMETHYLTRANSFERASE 2
Descriptor:Serine hydroxymethyltransferase, mitochondrial, UNKNOWN ATOM OR ION
Authors:Dong, A., Wu, H., Zeng, H., Loppnau, P., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2018-05-28
Release date:2018-06-20
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:HUMAN MITOCHONDRIAL SERINE HYDROXYMETHYLTRANSFERASe 2
to be published
6D2L
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CRYSTAL STRUCTURE OF HUMAN CARM1 WITH (S)-SKI-72
Descriptor:Histone-arginine methyltransferase CARM1, (2S,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-hydroxyphenyl)ethyl]hexanamide, SULFATE ION, ...
Authors:DONG, A., ZENG, H., WALKER, J.R., Hutchinson, A., Seitova, A., LUO, M., CAI, X.C., KE, W., WANG, J., SHI, C., ZHENG, W., LEE, J.P., IBANEZ, G., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)
Deposit date:2018-04-13
Release date:2018-05-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human CARM1 with (S)-SKI-72
to be published
6CW0
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CRYSTAL STRUCTURE OF CRYPTOSPORIDIUM PARVUM BROMODOMAIN CGD2_2690
Descriptor:Cgd2_2690 protein, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, GLYCEROL, ...
Authors:Dong, A., Lin, L., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Hui, R., Structural Genomics Consortium (SGC)
Deposit date:2018-03-29
Release date:2018-04-18
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Crystal structure of Cryptosporidium parvum bromodomain cgd2_2690
to be published
5V9I
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CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF G9A WITH MS0105
Descriptor:Histone-lysine N-methyltransferase EHMT2, ZINC ION, S-ADENOSYLMETHIONINE, ...
Authors:Dong, A., Zeng, H., Liu, J., Xiong, Y., Babault, N., Jin, J., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Wu, H., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2017-03-23
Release date:2018-03-21
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structure of catalytic domain of G9a with MS0105
to be published
5V9J
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CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF GLP WITH MS0105
Descriptor:Histone-lysine N-methyltransferase EHMT1, S-ADENOSYLMETHIONINE, N~2~-cyclohexyl-N~4~-(1-ethylpiperidin-4-yl)-6,7-dimethoxy-N~2~-methylquinazoline-2,4-diamine, ...
Authors:Dong, A., Zeng, H., Liu, J., Xiong, Y., Babault, N., Jin, J., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Wu, H., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2017-03-23
Release date:2018-03-21
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structure of catalytic domain of GLP with MS0105
to be published
6CBX
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CRYSTAL STRUCTURE OF HUMAN SET AND MYND DOMAIN CONTAINING PROTEIN 2 WITH MTF1497
Descriptor:N-lysine methyltransferase SMYD2, ZINC ION, [3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)azetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl)-1H-pyrrol-3-yl]methanone, ...
Authors:ZENG, H., DONG, A., Hutchinson, A., Seitova, A., TATLOCK, J., KUMPF, R., OWEN, A., TAYLOR, A., Casimiro-Garcia, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)
Deposit date:2018-02-05
Release date:2018-03-14
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal structure of human SET and MYND Domain Containing protein 2 with MTF1497
to be published
6CBY
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CRYSTAL STRUCTURE OF HUMAN SET AND MYND DOMAIN CONTAINING PROTEIN 2 WITH MTF9975
Descriptor:N-lysine methyltransferase SMYD2, ZINC ION, [3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)-3-methylazetidin-1-yl][1-({1-[(1R)-cyclohept-2-en-1-yl]piperidin-4-yl}methyl)-1H-pyrrol-3-yl]methanone
Authors:ZENG, H., DONG, A., Hutchinson, A., Seitova, A., TATLOCK, J., KUMPF, R., OWEN, A., TAYLOR, A., Casimiro-Garcia, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)
Deposit date:2018-02-05
Release date:2018-03-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of human SET and MYND Domain Containing protein 2 with MTF9975
to be published
6CD7
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CRYSTAL STRUCTURE OF APH(2")-IVA IN COMPLEX WITH PLAZOMICIN
Descriptor:APH(2'')-Id, CHLORIDE ION, (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-{[(2S,3R)-3-amino-6-{[(2-hydroxyethyl)amino]methyl}-3,4-dihydro-2H-pyran-2-yl]oxy}-2-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanamide
Authors:Stogios, P.J., Evdokimova, E., Dong, A., Di Leo, R., Savchenko, A., Satchell, K.J., Joachimiak, J., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2018-02-08
Release date:2018-02-28
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.
ACS Infect Dis, 4, 2018
5ULO
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CRYSTAL STRUCTURE OF 14-3-3 ZETA IN COMPLEX WITH A SERINE 124-PHOSPHORYLATED TBC1D7 PEPTIDE
Descriptor:14-3-3 protein zeta/delta, TBC1 domain family member 7, 1,2-ETHANEDIOL, ...
Authors:DONG, A., HU, J., MADIGAN, J., WALKER, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., TONG, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-01-25
Release date:2018-01-31
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide
to be published
6BY9
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CRYSTAL STRUCTURE OF EHMT1
Descriptor:Histone-lysine N-methyltransferase EHMT1, UNKNOWN ATOM OR ION
Authors:Dong, A., Wei, Y., Li, A., Tempel, W., Han, S., Sunnerhagen, M., Penn, L., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-12-20
Release date:2018-01-31
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of EHMT1
to be published
6BYB
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CRYSTAL STRUCTURE OF L3MBTL1 MBT DOMAIN WITH MBK14970
Descriptor:Lethal(3)malignant brain tumor-like protein 1, (S)-N-(cyclopropylmethyl)-N~2~-methyl-N-[2-methyl-2-(1-methylpiperidin-4-yl)propyl]alaninamide, 1,2-ETHANEDIOL, ...
Authors:DONG, A., DOBROVETSKY, E., NICHOLSON, B., COX, C., FISCHER, C., ARMACOST, K., SANDERS, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., Structural Genomics Consortium (SGC)
Deposit date:2017-12-20
Release date:2018-01-24
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structure of L3MBTL1 MBT Domain with MBK14970
to be published
6BYA
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CRYSTAL STRUCTURE OF LDBPK_091320 WITH INHIBITOR BOUND
Descriptor:Uncharacterized protein, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole, UNKNOWN ATOM OR ION
Authors:Dong, A., Lin, Y.H., Loppnau, P., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Hui, R., Structural Genomics Consortium (SGC)
Deposit date:2017-12-20
Release date:2018-01-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystal structure of LdBPK_091320.1 with with inhibitor bound
to be published
6BPI
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CRYSTAL STRUCTURE OF SETDB1 TUDOR DOMAIN WITH ARYL TRIAZOLE FRAGMENT PEPTIDE CONJUGATES
Descriptor:Histone-lysine N-methyltransferase SETDB1, MLY-SER-THR-E2G, SULFATE ION, ...
Authors:MADER, P., Mendoza-Sanchez, R., DONG, A., DOBROVETSKY, E., IQBAL, A., CORLESS, V., TEMPEL, W., LIEW, S.K., SMIL, D., DELA SENA, C.C., KENNEDY, S., DIAZ, D.B., SCHAPIRA, M., VEDADI, M., BROWN, P.J., Santhakumar, V., FRYE, S., Bountra, C., Edwards, A.M., YUDIN, A.K., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
Deposit date:2017-11-23
Release date:2017-12-27
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Crystal structure of SETDB1 Tudor domain with aryl triazole fragment peptide conjugates
to be published
6BHG
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CRYSTAL STRUCTURE OF SETDB1 WITH A MODIFIED H3 PEPTIDE
Descriptor:Histone-lysine N-methyltransferase SETDB1, Histone H3.1, UNKNOWN ATOM OR ION
Authors:Qin, S., Tempel, W., Dong, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2017-10-30
Release date:2017-12-06
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
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