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1Y4I
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CRYSTAL STRUCTURE OF CITROBACTER FREUNDII L-METHIONINE-LYASE
Descriptor:methionine gamma-lyase, SULFATE ION
Authors:Revtovich, S.V., Mamaeva, D.V., Morozova, E.A., Nikulin, A.D., Nikonov, S.V., Garber, M.B., Demidkina, T.V.
Deposit date:2004-12-01
Release date:2005-06-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of Citrobacter freundii L-methionine gamma-lyase.
Acta Crystallogr.,Sect.F, 61, 2005
2EZ1
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HOLO TYROSINE PHENOL-LYASE FROM CITROBACTER FREUNDII AT PH 8.0
Descriptor:Tyrosine phenol-lyase, POTASSIUM ION
Authors:Milic, D., Matkovic-Calogovic, D., Demidkina, T.V., Antson, A.A.
Deposit date:2005-11-10
Release date:2006-07-25
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of apo- and holo-tyrosine phenol-lyase reveal a catalytically critical closed conformation and suggest a mechanism for activation by K+ ions
Biochemistry, 45, 2006
2EZ2
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APO TYROSINE PHENOL-LYASE FROM CITROBACTER FREUNDII AT PH 8.0
Descriptor:Tyrosine phenol-lyase, POTASSIUM ION, PHOSPHATE ION
Authors:Milic, D., Matkovic-Calogovic, D., Demidkina, T.V., Antson, A.A.
Deposit date:2005-11-10
Release date:2006-07-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structures of apo- and holo-tyrosine phenol-lyase reveal a catalytically critical closed conformation and suggest a mechanism for activation by K+ ions
Biochemistry, 45, 2006
2TPL
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TYROSINE PHENOL-LYASE FROM CITROBACTER INTERMEDIUS COMPLEX WITH 3-(4'-HYDROXYPHENYL)PROPIONIC ACID, PYRIDOXAL-5'-PHOSPHATE AND CS+ ION
Descriptor:TYROSINE PHENOL-LYASE, CESIUM ION, HYDROXYPHENYL PROPIONIC ACID
Authors:Antson, A.A., Demidkina, T.V., Wilson, K.S.
Deposit date:1997-01-23
Release date:1997-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure of Citrobacter freundii tyrosine phenol-lyase complexed with 3-(4'-hydroxyphenyl)propionic acid, together with site-directed mutagenesis and kinetic analysis, demonstrates that arginine 381 is required for substrate specificity.
Biochemistry, 36, 1997
2VLF
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QUINONOID INTERMEDIATE OF CITROBACTER FREUNDII TYROSINE PHENOL-LYASE FORMED WITH ALANINE
Descriptor:TYROSINE PHENOL-LYASE, (2E)-2-{[(Z)-{3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4(1H)-YLIDENE}METHYL]IMINO}PROPANOIC ACID, TRIETHYLENE GLYCOL, ...
Authors:Milic, D., Demidkina, T.V., Matkovic-Calogovic, D., Antson, A.A.
Deposit date:2008-01-14
Release date:2008-08-19
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Insights Into the Catalytic Mechanism of Tyrosine Phenol-Lyase from X-Ray Structures of Quinonoid Intermediates.
J.Biol.Chem., 283, 2008
2VLH
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QUINONOID INTERMEDIATE OF CITROBACTER FREUNDII TYROSINE PHENOL-LYASE FORMED WITH METHIONINE
Descriptor:TYROSINE PHENOL-LYASE, (2E)-2-{[(Z)-{3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4(1H)-YLIDENE}METHYL]IMINO}-4-(METHYLSULFANYL)BUTANOIC ACID, POTASSIUM ION, ...
Authors:Milic, D., Demidkina, T.V., Matkovic-Calogovic, D., Antson, A.A.
Deposit date:2008-01-14
Release date:2008-08-19
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Insights Into the Catalytic Mechanism of Tyrosine Phenol-Lyase from X-Ray Structures of Quinonoid Intermediates.
J.Biol.Chem., 283, 2008
2YCN
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Y71F MUTANT OF TYROSINE PHENOL-LYASE FROM CITROBACTER FREUNDII IN COMPLEX WITH QUINONOID INTERMEDIATE FORMED WITH 3-FLUORO-L-TYROSINE
Descriptor:TYROSINE PHENOL-LYASE, POTASSIUM ION, (2E)-3-(3-fluoro-4-hydroxyphenyl)-2-{[(Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4(1H)-ylidene}methyl]imino}propanoic acid, ...
Authors:Milic, D., Demidkina, T.V., Faleev, N.G., Phillips, R.S., Matkovic-Calogovic, D., Antson, A.A.
Deposit date:2011-03-16
Release date:2011-09-14
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Crystallographic Snapshots of Tyrosine Phenol-Lyase Show that Substrate Strain Plays a Role in C-C Bond Cleavage
J.Am.Chem.Soc., 133, 2011
2YCP
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F448H MUTANT OF TYROSINE PHENOL-LYASE FROM CITROBACTER FREUNDII IN COMPLEX WITH QUINONOID INTERMEDIATE FORMED WITH 3-FLUORO-L-TYROSINE
Descriptor:TYROSINE PHENOL-LYASE, (2E)-3-(3-fluoro-4-hydroxyphenyl)-2-{[(Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4(1H)-ylidene}methyl]imino}propanoic acid, TRIETHYLENE GLYCOL, ...
Authors:Milic, D., Demidkina, T.V., Faleev, N.G., Phillips, R.S., Matkovic-Calogovic, D., Antson, A.A.
Deposit date:2011-03-16
Release date:2011-09-14
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallographic Snapshots of Tyrosine Phenol-Lyase Show that Substrate Strain Plays a Role in C-C Bond Cleavage
J.Am.Chem.Soc., 133, 2011
2YCT
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TYROSINE PHENOL-LYASE FROM CITROBACTER FREUNDII IN COMPLEX WITH PYRIDINE N-OXIDE AND THE QUINONOID INTERMEDIATE FORMED WITH L-ALANINE
Descriptor:TYROSINE PHENOL-LYASE, PYRIDOXAL-5'-PHOSPHATE, (2E)-2-{[(Z)-{3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4(1H)-YLIDENE}METHYL]IMINO}PROPANOIC ACID, ...
Authors:Milic, D., Demidkina, T.V., Faleev, N.G., Phillips, R.S., Matkovic-Calogovic, D., Antson, A.A.
Deposit date:2011-03-16
Release date:2011-09-14
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystallographic Snapshots of Tyrosine Phenol-Lyase Show that Substrate Strain Plays a Role in C-C Bond Cleavage
J.Am.Chem.Soc., 133, 2011
2YHK
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D214A MUTANT OF TYROSINE PHENOL-LYASE FROM CITROBACTER FREUNDII
Descriptor:TYROSINE PHENOL-LYASE, POTASSIUM ION, TETRAETHYLENE GLYCOL, ...
Authors:Milic, D., Demidkina, T.V., Matkovic-Calogovic, D., Antson, A.A.
Deposit date:2011-05-03
Release date:2012-05-02
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystal Structure of Citrobacter Freundii Asp214Ala Tyrosine Phenol-Lyase Reveals that Asp214 is Critical for Maintaining a Strain in the Internal Aldimine
Croatica Chemica Acta, 85, 2012
3JW9
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CRYSTAL STRUCTURE OF L-METHIONINE GAMMA-LYASE FROM CITROBACTER FREUNDII WITH S-ETHYL-CYSTEINE
Descriptor:Methionine gamma-lyase, S-ethyl-L-cysteine, DI(HYDROXYETHYL)ETHER
Authors:Revtovish, S.V., Nikulin, A.D., Morozova, E.A., Demidkina, T.V.
Deposit date:2009-09-18
Release date:2010-09-08
Last modified:2014-11-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Three-dimensional structures of noncovalent complexes of Citrobacter freundii methionine gamma-lyase with substrates.
Biochemistry Mosc., 76, 2011
3JWA
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CRYSTAL STRUCTURE OF L-METHIONINE GAMMA-LYASE FROM CITROBACTER FREUNDII WITH METHIONINE PHOSPHINATE
Descriptor:Methionine gamma-lyase, (1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHINIC ACID, DI(HYDROXYETHYL)ETHER
Authors:Revtovish, S.V., Nikulin, A.D., Morozova, E.A., Demidkina, T.V.
Deposit date:2009-09-18
Release date:2010-09-08
Last modified:2014-11-05
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Three-dimensional structures of noncovalent complexes of Citrobacter freundii methionine gamma-lyase with substrates.
Biochemistry Mosc., 76, 2011
3JWB
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CRYSTAL STRUCTURE OF L-METHIONINE GAMMA-LYASE FROM CITROBACTER FREUNDII WITH NORLEUCINE
Descriptor:Methionine gamma-lyase, NORLEUCINE, DI(HYDROXYETHYL)ETHER
Authors:Revtovish, S.V., Nikulin, A.D., Morozova, E.A., Demidkina, T.V.
Deposit date:2009-09-18
Release date:2010-09-08
Last modified:2014-11-05
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Three-dimensional structures of noncovalent complexes of Citrobacter freundii methionine gamma-lyase with substrates.
Biochemistry Mosc., 76, 2011
3MKJ
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METHIONINE GAMMA-LYASE FROM CITROBACTER FREUNDII WITH PYRIDOXIMINE-5'-PHOSPHATE
Descriptor:Methionine gamma-lyase, [5-hydroxy-4-(iminomethyl)-6-methyl-pyridin-3-yl]methyl dihydrogen phosphate
Authors:Revtovich, S.V., Nikulin, A.D., Morozova, E.A., Demidkina, T.V.
Deposit date:2010-04-15
Release date:2010-08-11
Last modified:2014-03-05
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Exploring methionine gamma-lyase structure-function relationship via microspectrophotometry and X-ray crystallography
Biochim.Biophys.Acta, 1814, 2011
4HF8
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CRYSTAL STRUCTURE OF L-METHIONINE GAMMA-LYASE FROM CITROBACTER FREUNDII WITH GLYCINE
Descriptor:Methionine gamma-lyase, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], GLYCINE, ...
Authors:Revtovich, S.V., Morozova, E.A., Anufrieva, N.V., Nikulin, A.D., Demidkina, T.V.
Deposit date:2012-10-05
Release date:2013-11-06
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of the external aldimine of Citrobacter freundii methionine gamma-lyase with glycine provides insight in mechanisms of two stages of physiological reaction and isotope exchange of alpha- and beta-protons of competitive inhibitors.
Biochimie, 101, 2014
4MKJ
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CRYSTAL STRUCTURE OF L-METHIONINE GAMMA-LYASE FROM CITROBACTER FREUNDII MODIFIED BY ALLICINE
Descriptor:Methionine gamma-lyase, PENTAETHYLENE GLYCOL, TRIETHYLENE GLYCOL, ...
Authors:Revtovich, S.V., Nikulin, A.D., Morozova, E.A., Zakomirdina, L.N., Demidkina, T.V.
Deposit date:2013-09-05
Release date:2014-11-12
Last modified:2014-12-31
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Alliin is a suicide substrate of Citrobacter freundii methionine gamma-lyase: structural bases of inactivation of the enzyme.
Acta Crystallogr.,Sect.D, 70, 2014
4MKK
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CRYSTAL STRUCTURE OF C115A MUTANT L-METHIONINE GAMMA-LYASE FROM CITROBACTER FREUNDII MODIFIED BY ALLICINE
Descriptor:Methionine gamma-lyase, TRIETHYLENE GLYCOL, SODIUM ION, ...
Authors:Revtovich, S.V., Nikulin, A.D., Morozova, E.A., Zakomirdina, L.N., Demidkina, T.V.
Deposit date:2013-09-05
Release date:2014-11-12
Last modified:2014-12-31
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Alliin is a suicide substrate of Citrobacter freundii methionine gamma-lyase: structural bases of inactivation of the enzyme.
Acta Crystallogr.,Sect.D, 70, 2014
4OMA
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THE CRYSTAL STRUCTURE OF METHIONINE GAMMA-LYASE FROM CITROBACTER FREUNDII IN COMPLEX WITH L-CYCLOSERINE PYRIDOXAL-5'-PHOSPHATE
Descriptor:methionine gamma-lyase, [5-hydroxy-6-methyl-4-({[(4E)-3-oxo-1,2-oxazolidin-4-ylidene]amino}methyl)pyridin-3-yl]methyl dihydrogen phosphate, TRIETHYLENE GLYCOL, ...
Authors:Revtovich, S.V., Nikulin, A.D., Morozova, E.A., Demidkina, T.V.
Deposit date:2014-01-27
Release date:2014-11-26
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Pre-steady-state Kinetic and Structural Analysis of Interaction of Methionine gamma-Lyase from Citrobacter freundii with Inhibitors.
J.Biol.Chem., 290, 2015
4P7Y
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L-METHIONINE GAMMA-LYASE FROM CITROBACTER FREUNDII WITH Y58F SUBSTITUTION
Descriptor:METHIONINE GAMMA-LYASE, DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL
Authors:Revtovich, S.V., Nikulin, A.D., Anufrieva, N.V., Morozova, E.A., Demidkina, T.V.
Deposit date:2014-03-28
Release date:2014-11-12
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal structure of L-methionine gamma-lyase from Citrobacter freundii with Y58F substitution
To Be Published
5D5S
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CRYSTAL STRUCTURE OF METHIONINE GAMMA-LYASE FROM CITROBACTER FREUNDII, S339A MUTANT
Descriptor:Methionine gamma-lyase, DI(HYDROXYETHYL)ETHER, SODIUM ION, ...
Authors:Revtovich, S.V., Nikulin, A.D., Anufrieva, N.V., Morozova, E.A., Demidkina, T.V.
Deposit date:2015-08-11
Release date:2016-08-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The crystal structure of methionine gamma-lyase from Citrobacter freundii, S339A mutant
To Be Published
5E4Z
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CRYSTAL STRUCTURE OF METHIONINE GAMMA-LYASE FROM CITROBACTER FREUNDII WITH C115A SUBSTITUTION
Descriptor:Methionine gamma-lyase, PENTAETHYLENE GLYCOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Revtovich, S.V., Nikulin, A.D., Anufrieva, N.V., Morozova, E.A., Demidkina, T.V.
Deposit date:2015-10-07
Release date:2016-10-12
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal structure of C115A mutant L-methionine gamma-lyase from Citrobacter freundii
To Be Published
5IJG
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CRYSTAL STRUCTURE OF O-ACETYLHOMOSERINE SULFHYDROLASE FROM BRUCELLA MELITENSIS AT 2.0 A RESOLUTION
Descriptor:Cys/Met metabolism pyridoxal-phosphate-dependent enzyme, PYRIDOXAL-5'-PHOSPHATE, GLYCEROL
Authors:Boyko, K.M., Nikolaeva, A.Y., Koolikova, V.V., Kotlov, M.I., Demidkina, T.V., Popov, V.O.
Deposit date:2016-03-02
Release date:2017-04-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of O-acetylhomoserine sulfhydrolase from Brucella melitensis at 2.0 A resolution
To Be Published
5K30
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CRYSTAL STRUCTURE OF METHIONINE GAMMA-LYASE FROM CITROBACTER FREUNDII MODIFIED BY S-ETHYL-L-CYSTEINE SULFOXIDE
Descriptor:Methionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE, PENTAETHYLENE GLYCOL, ...
Authors:Revtovich, S.V., Nikulin, A.D., Morozova, E.A., Demidkina, T.V.
Deposit date:2016-05-19
Release date:2017-07-12
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Crystal structure of methionine gamma-lyase from Citrobacter freundii modified by S-Ethyl-L-cysteine sulfoxide
To Be Published
5M3Z
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CRYSTAL STRUCTURE OF CITROBACTER FREUNDII METHIONINE GAMMA-LYASE WITH C115H REPLACEMENT IN THE COMPLEX WITH L-NORLEUCINE
Descriptor:Methionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE, NORLEUCINE, ...
Authors:Revtovich, S.V., Nikulin, A.D., Anufrieva, N.V., Morozova, E.A., Demidkina, T.V.
Deposit date:2016-10-17
Release date:2017-06-28
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of mutant form Cys115His of Citrobacter freundii methionine gamma-lyase complexed with l-norleucine.
Biochim. Biophys. Acta, 1865, 2017
6EGR
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CRYSTAL STRUCTURE OF CITROBACTER FREUNDII METHIONINE GAMMA-LYASE WITH V358Y REPLACEMENT
Descriptor:Methionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE, TRIETHYLENE GLYCOL, ...
Authors:Revtovich, S.V., Demitri, N., Raboni, S., Nikulin, A.D., Morozova, E.A., Demidkina, T.V., Storici, P., Mozzarelli, A.
Deposit date:2017-09-12
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of Citrobacter freundii methionine gamma-lyase with V358Y replacement
To Be Published
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