2YCT

Tyrosine phenol-lyase from Citrobacter freundii in complex with pyridine N-oxide and the quinonoid intermediate formed with L-alanine

Summary for 2YCT

• Entry DOI: 10.2210/pdb2yct/pdb
• Related: 1TPL 2EZ1 2EZ2 2TPL 2VLF 2VLH 2YCN 2YCP 2YHK
• Descriptor: TYROSINE PHENOL-LYASE, PYRIDOXAL-5'-PHOSPHATE, (2E)-2-{[(Z)-{3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4(1H)-YLIDENE}METHYL]IMINO}PROPANOIC ACID, ... (8 entities in total)
• Functional Keywords: lyase, pyridoxal 5'-phosphate dependent enzyme, beta-elimination
• Biological source: CITROBACTER FREUNDII
• Total number of polymer chains: 2
• Total formula weight: 104730.92

Authors

Milic, D.,Demidkina, T.V.,Faleev, N.G.,Phillips, R.S.,Matkovic-Calogovic, D.,Antson, A.A. (deposition date: 2011-03-16, release date: 2011-09-14, Last modification date: 2023-12-20)

• Primary citation: Milic, D.,Demidkina, T.V.,Faleev, N.G.,Phillips, R.S.,Matkovic-Calogovic, D.,Antson, A.A.; Crystallographic Snapshots of Tyrosine Phenol-Lyase Show that Substrate Strain Plays a Role in C-C Bond Cleavage; J.Am.Chem.Soc., 133:16468-, 2011; PubMed: 21899319; DOI: 10.1021/JA203361G

Experimental method

X-RAY DIFFRACTION (2.25 Å)