2TPL

TYROSINE PHENOL-LYASE FROM CITROBACTER INTERMEDIUS COMPLEX WITH 3-(4'-HYDROXYPHENYL)PROPIONIC ACID, PYRIDOXAL-5'-PHOSPHATE AND CS+ ION

Summary for 2TPL

Entry DOI	10.2210/pdb2tpl/pdb
Descriptor	TYROSINE PHENOL-LYASE, CESIUM ION, HYDROXYPHENYL PROPIONIC ACID, ... (4 entities in total)
Functional Keywords	lyase, plp-dependent enzyme, pyridoxal phosphate
Biological source	Citrobacter freundii
Total number of polymer chains	2
Total formula weight	103905.73
Authors	Antson, A.A.,Demidkina, T.V.,Wilson, K.S. (deposition date: 1997-01-23, release date: 1997-04-01, Last modification date: 2024-04-03)
Primary citation	Sundararaju, B.,Antson, A.A.,Phillips, R.S.,Demidkina, T.V.,Barbolina, M.V.,Gollnick, P.,Dodson, G.G.,Wilson, K.S. The crystal structure of Citrobacter freundii tyrosine phenol-lyase complexed with 3-(4'-hydroxyphenyl)propionic acid, together with site-directed mutagenesis and kinetic analysis, demonstrates that arginine 381 is required for substrate specificity. Biochemistry, 36:6502-6510, 1997 Cited by PubMed: 9174368 DOI: 10.1021/bi962917+ PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation