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3L4B
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BU of 3l4b by Molmil
Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima
Descriptor: ADENOSINE MONOPHOSPHATE, TrkA K+ Channel protein TM1088A, TrkA K+ Channel protein TM1088B, ...
Authors:Deller, M.C, Johnson, H.A, Miller, M, Spraggon, G, Wilson, I.A, Lesley, S.A, Joint Center for Structural Genomics (JCSG)
Deposit date:2009-12-18
Release date:2010-02-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima
To be Published
1EVS
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BU of 1evs by Molmil
CRYSTAL STRUCTURE OF HUMAN ONCOSTATIN M
Descriptor: ONCOSTATIN M
Authors:Deller, M.C, Hudson, K.R, Ikemizu, S, Bravo, J, Jones, E.Y, Heath, J.K.
Deposit date:2000-04-20
Release date:2000-09-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure and functional dissection of the cytostatic cytokine oncostatin M.
Structure Fold.Des., 8, 2000
3JXO
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BU of 3jxo by Molmil
Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima
Descriptor: TrkA-N domain protein
Authors:Deller, M.C, Johnson, H.A, Miller, M, Spraggon, G, Wilson, I.A, Lesley, S.A, Joint Center for Structural Genomics (JCSG)
Deposit date:2009-09-20
Release date:2009-10-06
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima
To be Published
8UV0
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BU of 8uv0 by Molmil
Discovery of (4-Pyrazolyl)-2-Aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2
Descriptor: 1-{(4M)-4-[2-{[1-(cyclopropanesulfonyl)piperidin-4-yl]amino}-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrazol-1-yl}-2-methylpropan-2-ol, Cyclin-dependent kinase 2
Authors:Deller, M.C, Epling, L.B.
Deposit date:2023-11-02
Release date:2024-02-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2.
J.Med.Chem., 67, 2024
8E1X
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BU of 8e1x by Molmil
FGFR2 kinase domain in complex with a Pyrazolo[1,5-a]pyrimidine analog (Compound 29)
Descriptor: (5M)-N-methyl-5-{(6M,8S)-5-{[(3S)-oxolan-3-yl]amino}-6-[1-(propan-2-yl)-1H-pyrazol-3-yl]pyrazolo[1,5-a]pyrimidin-3-yl}pyridine-3-carboxamide, Fibroblast growth factor receptor 2
Authors:Lei, H.-T, Epling, L.B, Deller, M.C.
Deposit date:2022-08-11
Release date:2022-11-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3.
J.Med.Chem., 65, 2022
5UFV
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BU of 5ufv by Molmil
Crystal Structure of a Cellulose-active Polysaccharide Monooxygenase from M. thermophila (MtPMO3*)
Descriptor: COPPER (II) ION, Glycoside hydrolase family 61 protein
Authors:Span, E.A, Deller, M.C, Marletta, M.A.
Deposit date:2017-01-05
Release date:2017-03-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The Role of the Secondary Coordination Sphere in a Fungal Polysaccharide Monooxygenase.
ACS Chem. Biol., 12, 2017
1VLQ
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BU of 1vlq by Molmil
Crystal structure of Acetyl xylan esterase (TM0077) from Thermotoga maritima at 2.10 A resolution
Descriptor: GLYCEROL, acetyl xylan esterase
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2004-08-09
Release date:2004-08-24
Last modified:2023-01-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima.
Proteins, 80, 2012
3KK7
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BU of 3kk7 by Molmil
Crystal structure of Putative cell invasion protein with MAC/Perforin domain (NP_812351.1) from BACTERIODES THETAIOTAOMICRON VPI-5482 at 2.46 A resolution
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2009-11-04
Release date:2009-11-24
Last modified:2023-02-01
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Structure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiont Bacteroides thetaiotaomicron.
Acta Crystallogr.,Sect.F, 66, 2010
3L5O
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BU of 3l5o by Molmil
Crystal structure of protein with unknown function from DUF364 family (ZP_00559375.1) from Desulfitobacterium hafniense DCB-2 at 2.01 A resolution
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, IMIDAZOLE, ...
Authors:Joint Center for Structural Genomics, Joint Center for Structural Genomics (JCSG)
Deposit date:2009-12-22
Release date:2010-02-02
Last modified:2023-02-01
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and Rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation.
Acta Crystallogr.,Sect.F, 66, 2010
3M82
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BU of 3m82 by Molmil
Crystal structure of Acetyl xylan esterase (TM0077) from THERMOTOGA MARITIMA at 2.40 A resolution (PMSF inhibitor complex structure)
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Acetyl xylan esterase, ...
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2010-03-17
Release date:2010-05-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima.
Proteins, 80, 2012
3M81
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BU of 3m81 by Molmil
Crystal structure of Acetyl xylan esterase (TM0077) from THERMOTOGA MARITIMA at 2.50 A resolution (native apo structure)
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Acetyl xylan esterase, ...
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2010-03-17
Release date:2010-04-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima.
Proteins, 80, 2012
3M83
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BU of 3m83 by Molmil
Crystal structure of Acetyl xylan esterase (TM0077) from THERMOTOGA MARITIMA at 2.12 A resolution (paraoxon inhibitor complex structure)
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Acetyl xylan esterase, ...
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2010-03-17
Release date:2010-05-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima.
Proteins, 80, 2012
6OFO
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BU of 6ofo by Molmil
Crystal structure of split green fluorescent protein (GFP); s10 circular permutant (194-195)
Descriptor: Green fluorescent protein (GFP); s10 circular permutant (194-195)
Authors:Lin, C.-Y, Romei, M.G, Deller, M.C, Doukov, T.I, Boxer, S.G.
Deposit date:2019-03-31
Release date:2019-07-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.603 Å)
Cite:Unified Model for Photophysical and Electro-Optical Properties of Green Fluorescent Proteins.
J.Am.Chem.Soc., 141, 2019
6C9U
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BU of 6c9u by Molmil
Crystal structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase in complex with antibody fragment (Fab)
Descriptor: 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, Heavy chain of Fab 1B2, ...
Authors:Deis, L.N, Li, X, Mathews, I.I, Khosla, C.
Deposit date:2018-01-28
Release date:2018-05-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module.
J. Am. Chem. Soc., 140, 2018
5C7K
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BU of 5c7k by Molmil
Crystal structure BG505 SOSIP gp140 HIV-1 Env trimer bound to broadly neutralizing antibodies PGT128 and 8ANC195
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab 8ANC195 heavy chain, ...
Authors:Kong, L, Stanfield, R.L, Wilson, I.A.
Deposit date:2015-06-24
Release date:2015-10-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (4.6019 Å)
Cite:Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer.
Acta Crystallogr.,Sect.D, 71, 2015
4RBO
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BU of 4rbo by Molmil
Crystal structure of a Nanog homeobox (NANOG) from Homo sapiens at 3.30 A resolution
Descriptor: 5'-D(*CP*TP*TP*GP*AP*AP*TP*GP*GP*GP*CP*C)-3', 5'-D(*GP*GP*CP*CP*CP*AP*TP*TP*CP*AP*AP*G)-3', Putative homeobox protein NANOGP8
Authors:Joint Center for Structural Genomics (JCSG), Partnership for Stem Cell Biology (STEMCELL)
Deposit date:2014-09-12
Release date:2014-10-01
Last modified:2023-02-01
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.
Proc.Natl.Acad.Sci.USA, 112, 2015
5SY8
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BU of 5sy8 by Molmil
Crystal structure of the complex of 10E8 Fab light chain mutant1 and T117v2 HIV-1 MPER scaffold
Descriptor: 10E8 EPITOPE SCAFFOLD T117v2, 10E8 FAB HEAVY CHAIN, 10E8 FAB LIGHT CHAIN, ...
Authors:Irimia, A, Wilson, I.A.
Deposit date:2016-08-10
Release date:2017-03-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.
PLoS Pathog., 13, 2017
5T5B
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BU of 5t5b by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX OF 10E8 FAB LIGHT CHAIN MUTANT5 AND T117V2 HIV-1 MPER SCAFFOLD
Descriptor: 10E8 EPITOPE SCAFFOLD T117V2, Antibody 10E8 FAB HEAVY CHAIN, Antibody 10E8 FAB LIGHT CHAIN MUTATED, ...
Authors:Irimia, A, Wilson, I.A.
Deposit date:2016-08-30
Release date:2017-03-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.
PLoS Pathog., 13, 2017
5T29
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BU of 5t29 by Molmil
Crystal structure of 10E8 Fab light chain mutant3, against the MPER region of the HIV-1 Env, in complex with the MPER epitope scaffold T117v2
Descriptor: 10E8 EPITOPE SCAFFOLD T117V2, Antibody 10E8 FAB HEAVY CHAIN, Antibody 10E8 FAB LIGHT CHAIN, ...
Authors:Irimia, A, Wilson, I.A.
Deposit date:2016-08-23
Release date:2017-03-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.
PLoS Pathog., 13, 2017
5T6L
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BU of 5t6l by Molmil
Crystal structure of 10E8 Fab in complex with the MPER epitope scaffold T117v2
Descriptor: 10E8 EPITOPE SCAFFOLD T117V2, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Antibody 10E8 FAB HEAVY CHAIN, ...
Authors:Irimia, A, Wilson, I.A.
Deposit date:2016-09-01
Release date:2017-03-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.
PLoS Pathog., 13, 2017
5TFW
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BU of 5tfw by Molmil
Crystal structure of 10E8 Fab light chain mutant2 against the MPER region of the HIV-1 Env, in complex with T117v2 epitope scaffold
Descriptor: 1,2-ETHANEDIOL, 10E8 EPITOPE SCAFFOLD T117V2, Antibody 10E8 FAB HEAVY CHAIN, ...
Authors:Irimia, A, Wilson, I.A.
Deposit date:2016-09-26
Release date:2017-03-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.168 Å)
Cite:Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.
PLoS Pathog., 13, 2017
5T80
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BU of 5t80 by Molmil
Crystal structure of 10E8 Fab in complex with the MPER epitope scaffold T117v2 and phosphatidic acid (06:0 PA)
Descriptor: (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate, 10E8 EPITOPE SCAFFOLD T117V2, Antibody 10E8 FAB HEAVY CHAIN, ...
Authors:Irimia, A, Wilson, I.A.
Deposit date:2016-09-06
Release date:2017-03-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.
PLoS Pathog., 13, 2017
4NCO
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BU of 4nco by Molmil
Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 SOSIP gp120, BG505 SOSIP gp41, ...
Authors:Julien, J.-P, Stanfield, R.L, Lyumkis, D, Ward, A.B, Wilson, I.A.
Deposit date:2013-10-24
Release date:2013-11-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (4.7 Å)
Cite:Crystal structure of a soluble cleaved HIV-1 envelope trimer.
Science, 342, 2013
4G6A
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BU of 4g6a by Molmil
Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33
Descriptor: AP33 Heavy Chain, AP33 Light chain, E2 peptide
Authors:Kong, L, Wilson, I.A, Law, M.
Deposit date:2012-07-18
Release date:2012-09-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Structure of Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Site 412 to 423 in Complex with Antibody AP33.
J.Virol., 86, 2012
5T85
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BU of 5t85 by Molmil
Crystal structure of 10E8 Fab in complex with the MPER epitope scaffold T117v2 and phosphatidylglycerol (06:0 PG)
Descriptor: (2S)-3-{[(R)-{[(2R)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, 10E8 EPITOPE SCAFFOLD T117V2, Antibody 10E8 FAB HEAVY CHAIN, ...
Authors:Irimia, A, Wilson, I.A.
Deposit date:2016-09-06
Release date:2017-03-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.373 Å)
Cite:Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design.
PLoS Pathog., 13, 2017

 

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