4RBO
Crystal structure of a Nanog homeobox (NANOG) from Homo sapiens at 3.30 A resolution
Summary for 4RBO
Entry DOI | 10.2210/pdb4rbo/pdb |
Descriptor | Putative homeobox protein NANOGP8, 5'-D(*GP*GP*CP*CP*CP*AP*TP*TP*CP*AP*AP*G)-3', 5'-D(*CP*TP*TP*GP*AP*AP*TP*GP*GP*GP*CP*C)-3' (3 entities in total) |
Functional Keywords | homeobox, pf00046 family, structural genomics, joint center for structural genomics, jcsg, partnership for stem cell biology, stemcell, protein structure initiative, psi-biology, dna binding protein, transcription, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : Q6NSW7 |
Total number of polymer chains | 6 |
Total formula weight | 31873.46 |
Authors | Joint Center for Structural Genomics (JCSG),Partnership for Stem Cell Biology (STEMCELL) (deposition date: 2014-09-12, release date: 2014-10-01, Last modification date: 2023-02-01) |
Primary citation | Hayashi, Y.,Caboni, L.,Das, D.,Yumoto, F.,Clayton, T.,Deller, M.C.,Nguyen, P.,Farr, C.L.,Chiu, H.J.,Miller, M.D.,Elsliger, M.A.,Deacon, A.M.,Godzik, A.,Lesley, S.A.,Tomoda, K.,Conklin, B.R.,Wilson, I.A.,Yamanaka, S.,Fletterick, R.J. Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells. Proc.Natl.Acad.Sci.USA, 112:4666-4671, 2015 Cited by PubMed: 25825768DOI: 10.1073/pnas.1502855112 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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