5SY8

Crystal structure of the complex of 10E8 Fab light chain mutant1 and T117v2 HIV-1 MPER scaffold

Summary for 5SY8

Entry DOI	10.2210/pdb5sy8/pdb
Descriptor	10E8 FAB HEAVY CHAIN, 10E8 FAB LIGHT CHAIN, 10E8 EPITOPE SCAFFOLD T117v2, ... (5 entities in total)
Functional Keywords	hiv-1 gp41 mper, 10e8 fab, lipid membrane, immune system
Biological source	Homo sapiens More
Total number of polymer chains	3
Total formula weight	67205.00
Authors	Irimia, A.,Wilson, I.A. (deposition date: 2016-08-10, release date: 2017-03-08, Last modification date: 2023-10-04)
Primary citation	Irimia, A.,Serra, A.M.,Sarkar, A.,Jacak, R.,Kalyuzhniy, O.,Sok, D.,Saye-Francisco, K.L.,Schiffner, T.,Tingle, R.,Kubitz, M.,Adachi, Y.,Stanfield, R.L.,Deller, M.C.,Burton, D.R.,Schief, W.R.,Wilson, I.A. Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design. PLoS Pathog., 13:e1006212-e1006212, 2017 Cited by PubMed: 28225819 DOI: 10.1371/journal.ppat.1006212 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.62 Å)

Structure validation