Author results

4I0C
  • Download 4i0c
  • View 4i0c
Molmil generated image of 4i0c
THE STRUCTURE OF THE CAMELID ANTIBODY CABHUL5 IN COMPLEX WITH HUMAN LYSOZYME
Descriptor:Lysozyme C, cAbHuL5 antibody, CHLORIDE ION, ...
Authors:De Genst, E., Chan, P.H., Pardon, E., Kumita, J.R., Christodoulou, J., Menzer, L., Chirgadze, D.Y., Robinson, C.V., Muyldermans, S., Matagne, A., Wyns, L., Dobson, C.M., Dumoulin, M.
Deposit date:2012-11-16
Release date:2013-10-09
Last modified:2013-11-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.
J.Phys.Chem.B, 117, 2013
1RI8
  • Download 1ri8
  • View 1ri8
Molmil generated image of 1ri8
CRYSTAL STRUCTURE OF THE CAMELID SINGLE DOMAIN ANTIBODY 1D2L19 IN COMPLEX WITH HEN EGG WHITE LYSOZYME
Descriptor:camelid ANTIBODY HEAVY CHAIN, Lysozyme C, GLYCEROL
Authors:De Genst, E., Silence, K., Ghahroudi, M.A., Decanniere, K., Loris, R., Kinne, J., Wyns, L., Muyldermans, S.
Deposit date:2003-11-17
Release date:2005-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Strong in vivo maturation compensates for structurally restricted H3 loops in antibody repertoires.
J.Biol.Chem., 280, 2005
1RJC
  • Download 1rjc
  • View 1rjc
Molmil generated image of 1rjc
CRYSTAL STRUCTURE OF THE CAMELID SINGLE DOMAIN ANTIBODY CAB-LYS2 IN COMPLEX WITH HEN EGG WHITE LYSOZYME
Descriptor:camelid heavy chain antibody, Lysozyme C, PHOSPHATE ION, ...
Authors:De Genst, E., Silence, K., Ghahroudi, M.A., Decanniere, K., Loris, R., Kinne, J., Wyns, L., Muyldermans, S.
Deposit date:2003-11-19
Release date:2005-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Strong in vivo maturation compensates for structurally restricted H3 loops in antibody repertoires.
J.Biol.Chem., 280, 2005
1XFP
  • Download 1xfp
  • View 1xfp
Molmil generated image of 1xfp
CRYSTAL STRUCTURE OF THE CDR2 GERMLINE REVERSION MUTANT OF CAB-LYS3 IN COMPLEX WITH HEN EGG WHITE LYSOZYME
Descriptor:heavy chain antibody, Lysozyme C, FORMIC ACID
Authors:De Genst, E., Handelberg, F., Van Meirhaeghe, A., Vynck, S., Loris, R., Wyns, L., Muyldermans, S.
Deposit date:2004-09-15
Release date:2004-09-28
Last modified:2013-02-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Chemical Basis for the Affinity Maturation of a Camel Single Domain Antibody
J.Biol.Chem., 279, 2004
1ZV5
  • Download 1zv5
  • View 1zv5
Molmil generated image of 1zv5
CRYSTAL STRUCTURE OF THE VARIABLE DOMAIN OF THE CAMELID HEAVY-CHAIN ANTIBODY D2-L29 IN COMPLEX WITH HEN EGG WHITE LYSOZYME
Descriptor:Lysozyme C, immunoglobulin heavy chain antibody variable domain, PHOSPHATE ION
Authors:De Genst, E., Silence, K., Decanniere, K., Conrath, K., Loris, R., Kinne, J., Muyldermans, S., Wyns, L.
Deposit date:2005-06-01
Release date:2006-04-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies.
Proc.Natl.Acad.Sci.Usa, 103, 2006
1ZVH
  • Download 1zvh
  • View 1zvh
Molmil generated image of 1zvh
CRYSTAL STRUCTURE OF THE VHH DOMAIN D2-L24 IN COMPLEX WITH HEN EGG WHITE LYSOZYME
Descriptor:Lysozyme C, Immunoglobulin heavy chain antibody variable domain
Authors:De Genst, E., Silence, K., Decanniere, K., Conrath, K., Loris, R., Kinne, J., Muyldermans, S., Wyns, L.
Deposit date:2005-06-02
Release date:2006-04-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies.
Proc.Natl.Acad.Sci.Usa, 103, 2006
1ZVY
  • Download 1zvy
  • View 1zvy
Molmil generated image of 1zvy
CRYSTAL STRUCTURE OF THE VHH D3-L11 IN COMPLEX WITH HEN EGG WHITE LYSOZYME
Descriptor:Immunoglobulin heavy chain antibody variable domain, Lysozyme C, PHOSPHATE ION, ...
Authors:De Genst, E., Silence, K., Decanniere, K., Conrath, K., Loris, R., Kinne, J., Muyldermans, S., Wyns, L.
Deposit date:2005-06-03
Release date:2006-04-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies.
Proc.Natl.Acad.Sci.Usa, 103, 2006
4RAV
  • Download 4rav
  • View 4rav
Molmil generated image of 4rav
CRYSTAL STRUCTURE OF SCFVC4 IN COMPLEX WITH THE FIRST 17 AA OF HUNTINGTIN
Descriptor:Single-chain Fv, VL, single-chain Fv, ...
Authors:De Genst, E., Chirgadze, D.Y., Dobson, C.M.
Deposit date:2014-09-11
Release date:2015-07-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a single-chain fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression.
J.Mol.Biol., 427, 2015
1O9V
  • Download 1o9v
  • View 1o9v
Molmil generated image of 1o9v
F17-AG LECTIN DOMAIN FROM ESCHERICHIA COLI IN COMPLEX WITH A SELENIUM CARBOHYDRATE DERIVATIVE
Descriptor:F17-AG LECTIN DOMAIN, METHYL 2-ACETAMIDO-1,2-DIDEOXY-1-SELENO-BETA-D-GLUCOPYRANOSIDE
Authors:Buts, L., De Genst, E., Loris, R., Oscarson, S., Lahmann, M., Messens, J., Brosens, E., Wyns, L., Bouckaert, J., De Greve, H.
Deposit date:2002-12-20
Release date:2003-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The Fimbrial Adhesin F17-G of Enterotoxigenic Escherichia Coli Has an Immunoglobulin-Like Lectin Domain that Binds N-Acetylglucosamine
Mol.Microbiol., 49, 2003
1O9W
  • Download 1o9w
  • View 1o9w
Molmil generated image of 1o9w
F17-AG LECTIN DOMAIN FROM ESCHERICHIA COLI IN COMPLEX WITH N-ACETYL-GLUCOSAMINE
Descriptor:F17A-G FIMBRIAL ADHESIN, N-ACETYL-D-GLUCOSAMINE
Authors:Buts, L., De Genst, E., Loris, R., Oscarson, S., Lahmann, M., Messens, J., Brosens, E., Wyns, L., Bouckaert, J., De Greve, H.
Deposit date:2002-12-20
Release date:2003-05-29
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The Fimbrial Adhesin F17-G of Enterotoxigenic Escherichia Coli Has an Immunoglobulin-Like Lectin Domain that Binds N-Acetylglucosamine
Mol.Microbiol., 49, 2003
1O9Z
  • Download 1o9z
  • View 1o9z
Molmil generated image of 1o9z
F17-AG LECTIN DOMAIN FROM ESCHERICHIA COLI (LIGAND FREE)
Descriptor:F17-AG LECTIN DOMAIN
Authors:Buts, L., De Genst, E., Loris, R., Oscarson, S., Lahmann, M., Messens, J., Brosens, E., Wyns, L., Bouckaert, J., De Greve, H.
Deposit date:2002-12-23
Release date:2003-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The Fimbrial Adhesin F17-G of Enterotoxigenic Escherichia Coli Has an Immunoglobulin-Like Lectin Domain that Binds N-Acetylglucosamine
Mol.Microbiol., 49, 2003
1TR7
  • Download 1tr7
  • View 1tr7
Molmil generated image of 1tr7
FIMH ADHESIN RECEPTOR BINDING DOMAIN FROM UROPATHOGENIC E. COLI
Descriptor:FimH protein, BUTYL ALPHA-D-MANNOPYRANOSIDE, CACODYLATE ION, ...
Authors:Bouckaert, J., Berglund, J., Schembri, M., De Genst, E., Cools, L., Wuhrer, M., Hung, C.S., Pinkner, J., Slattegard, R., Zavialov, A., Choudhury, D., Langermann, S., Hultgren, S.J., Wyns, L., Klemm, P., Oscarson, S., Knight, S.D., De Greve, H.
Deposit date:2004-06-21
Release date:2005-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin
Mol.Microbiol., 55, 2005
1X75
  • Download 1x75
  • View 1x75
Molmil generated image of 1x75
CCDB:GYRA14 COMPLEX
Descriptor:DNA gyrase subunit A, Cytotoxic protein ccdB
Authors:Dao-Thi, M.H., Van Melderen, L., De Genst, E., Wyns, L., Loris, R.
Deposit date:2004-08-13
Release date:2005-05-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular Basis of Gyrase Poisoning by the Addiction Toxin CcdB
J.Mol.Biol., 348, 2005
1UWF
  • Download 1uwf
  • View 1uwf
Molmil generated image of 1uwf
1.7 A RESOLUTION STRUCTURE OF THE RECEPTOR BINDING DOMAIN OF THE FIMH ADHESIN FROM UROPATHOGENIC E. COLI
Descriptor:FIMH PROTEIN, BUTYL ALPHA-D-MANNOPYRANOSIDE, GLYCEROL
Authors:Bouckaert, J., Berglund, J., Genst, E.D., Cools, L., Hung, C.-S., Wuhrer, M., Zavialov, A., Langermann, S., Hultgren, S., Wyns, L., Oscarson, S., Knight, S.D., De Greve, H.
Deposit date:2004-02-05
Release date:2005-02-16
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Receptor Binding Studies Disclose a Novel Class of High-Affinity Inhibitors of the Escherichia Coli Fimh Adhesin.
Mol.Microbiol., 55, 2005
3F64
  • Download 3f64
  • View 3f64
Molmil generated image of 3f64
F17A-G LECTIN DOMAIN WITH BOUND GLCNAC(BETA1-O)PARANITROPHENYL LIGAND
Descriptor:F17a-G, N-[(2S,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-nitrophenoxy)oxan-3-yl]ethanamide
Authors:Buts, L., De Boer, A., Olsson, J.D.M., Jonckheere, W., De Kerpel, M., De Genst, E., Guerardel, Y., Willaert, R., Wyns, L., Wuhrer, M., Oscarson, S., De Greve, H., Bouckaert, J.
Deposit date:2008-11-05
Release date:2009-11-10
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Sampling of Glycan Interaction Profiles Reveals Mucosal Receptors for Fimbrial Adhesins of Enterotoxigenic Escherichia coli
Biology, 2, 2013
3F6J
  • Download 3f6j
  • View 3f6j
Molmil generated image of 3f6j
F17A-G LECTIN DOMAIN WITH BOUND GLCNAC(BETA1-3)GAL
Descriptor:F17a-G, N-ACETYL-D-GLUCOSAMINE, METHYL-BETA-GALACTOSE
Authors:Buts, L., de Boer, A., Olsson, J.D.M., Jonckheere, W., De Kerpel, M., De Genst, E., Guerardel, Y., Willaert, R., Wyns, L., Wuhrer, M., Oscarson, S., De Greve, H., Bouckaert, J.
Deposit date:2008-11-06
Release date:2009-11-17
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Sampling of Glycan Interaction Profiles Reveals Mucosal Receptors for Fimbrial Adhesins of Enterotoxigenic Escherichia coli
Biology, 2, 2013
3FFO
  • Download 3ffo
  • View 3ffo
Molmil generated image of 3ffo
F17B-G LECTIN DOMAIN WITH BOUND GLCNAC(BETA1-2)MAN
Descriptor:Adhesin, NICKEL (II) ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Buts, L., De Boer, A., Olsson, J.D.M., Jonckheere, W., De Kerpel, M., De Genst, E., Guerardel, Y., Willaert, R., Wyns, L., Wuhrer, M., Oscarson, S., De Greve, H., Bouckaert, J.
Deposit date:2008-12-04
Release date:2009-12-22
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Sampling of Glycan Interaction Profiles Reveals Mucosal Receptors for Fimbrial Adhesins of Enterotoxigenic Escherichia coli.
Biology (Basel), 2, 2013
1ZK5
  • Download 1zk5
  • View 1zk5
Molmil generated image of 1zk5
ESCHERICHIA COLI F17FG LECTIN DOMAIN COMPLEX WITH N-ACETYLGLUCOSAMINE
Descriptor:F17G adhesin subunit, N-ACETYL-D-GLUCOSAMINE
Authors:Buts, L., Wellens, A., Van Molle, I., De Genst, E., Wyns, L., Loris, R., Lahmann, M., Oscarson, S., De Greve, H., Bouckaert, J.
Deposit date:2005-05-02
Release date:2006-05-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Impact of natural variation in bacterial F17G adhesins on crystallization behaviour.
Acta Crystallogr.,Sect.D, 61, 2005
1KXQ
  • Download 1kxq
  • View 1kxq
Molmil generated image of 1kxq
CAMELID VHH DOMAIN IN COMPLEX WITH PORCINE PANCREATIC ALPHA-AMYLASE
Descriptor:alpha-amylase, pancreatic, antibody VHH fragment CABAMD9, ...
Authors:Desmyter, A., Spinelli, S., Payan, F., Lauwereys, M., Wyns, L., Muyldermans, S., Cambillau, C.
Deposit date:2002-02-01
Release date:2002-06-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
1KXT
  • Download 1kxt
  • View 1kxt
Molmil generated image of 1kxt
CAMELID VHH DOMAINS IN COMPLEX WITH PORCINE PANCREATIC ALPHA-AMYLASE
Descriptor:ALPHA-AMYLASE, PANCREATIC, IMMUNOGLOBULIN VHH FRAGMENT, ...
Authors:Desmyter, A., Spinelli, S., Payan, F., Lauwereys, M., Wyns, L., Muyldermans, S., Cambillau, C.
Deposit date:2002-02-01
Release date:2002-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
1KXV
  • Download 1kxv
  • View 1kxv
Molmil generated image of 1kxv
CAMELID VHH DOMAINS IN COMPLEX WITH PORCINE PANCREATIC ALPHA-AMYLASE
Descriptor:ALPHA-AMYLASE, PANCREATIC, CAMELID VHH DOMAIN CAB10
Authors:Desmyter, A., Spinelli, S., Payan, F., Lauwereys, M., Wyns, L., Muyldermans, S., Cambillau, C.
Deposit date:2002-02-01
Release date:2002-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002