Author results

1W0Y
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TF7A_3771 COMPLEX
Descriptor:BLOOD COAGULATION FACTOR VIIA, TISSUE FACTOR, 4-(4-BENZYLOXY-2-METHANESULFONYLAMINO-5-METHOXY-BENZYLAMINO)-BENZAMIDINE, ...
Authors:Banner, D.W., D'Arcy, A., Groebke-Zbinden, K., Ackermann, J., Kirchhofer, D., Ji, Y.-H., Tschopp, T.B., Wallbaum, S., Weber, L.
Deposit date:2004-05-27
Release date:2005-01-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design of Selective Phenylglycine Amide Tissue Factor/Factor Viia Inhibitors
Bioorg.Med.Chem.Lett., 15, 2005
1QXW
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CRYSTAL STRUCTURE OF STAPHYLOCCOCUS AUREUS IN COMPLEX WITH AN AMINOKETONE INHIBITOR 54135.
Descriptor:methionyl aminopeptidase, COBALT (II) ION, ACETATE ION, ...
Authors:Douangamath, A., Dale, G.E., D'Arcy, A., Oefner, C.
Deposit date:2003-09-09
Release date:2004-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Crystal structures of staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate.
J.Med.Chem., 47, 2004
1QXY
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CRYSTAL STRUCTURE OF S. AUREUS METHIONINE AMINOPEPTIDASE IN COMPLEX WITH A KETOHETEROCYCLE 618
Descriptor:methionyl aminopeptidase, COBALT (II) ION, ACETATE ION, ...
Authors:Douangamath, A., Dale, G.E., D'Arcy, A., Oefner, C.
Deposit date:2003-09-09
Release date:2004-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:Crystal structures of staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate.
J.Med.Chem., 47, 2004
1QXZ
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CRYSTAL STRUCTURE OF S. AUREUS METHIONINE AMINOPEPTIDASE IN COMPLEX WITH A KETOHETEROCYCLE INHIBITOR 119
Descriptor:methionyl aminopeptidase, COBALT (II) ION, (2S)-2-AMINO-4-(METHYLSULFANYL)-1-(1,3-THIAZOL-2-YL)BUTANE-1,1-DIOL
Authors:Douangamath, A., Dale, G.E., D'Arcy, A., Oefner, C.
Deposit date:2003-09-09
Release date:2004-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Crystal structures of staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate.
J.Med.Chem., 47, 2004
1PFQ
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CRYSTAL STRUCTURE OF HUMAN APO DIPEPTIDYL PEPTIDASE IV / CD26
Descriptor:Dipeptidyl peptidase IV soluble form, N-ACETYL-D-GLUCOSAMINE
Authors:Oefner, C., D'Arcy, A., Mac Sweeney, A., Pierau, S., Gardiner, R., Dale, G.E.
Deposit date:2003-05-27
Release date:2003-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine.
Acta Crystallogr.,Sect.D, 59, 2003
1AD1
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DIHYDROPTEROATE SYNTHETASE (APO FORM) FROM STAPHYLOCOCCUS AUREUS
Descriptor:DIHYDROPTEROATE SYNTHETASE, POTASSIUM ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Kostrewa, D., Oefner, C., D'Arcy, A.
Deposit date:1997-02-19
Release date:1998-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and function of the dihydropteroate synthase from Staphylococcus aureus.
J.Mol.Biol., 268, 1997
1CBK
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7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE FROM HAEMOPHILUS INFLUENZAE
Descriptor:PROTEIN (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE), SULFATE ION, 7,8-DIHYDRO-7,7-DIMETHYL-6-HYDROXYPTERIN
Authors:Hennig, M., D'Arcy, A., Dale, G., Oefner, C.
Deposit date:1999-02-26
Release date:2000-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae.
J.Mol.Biol., 287, 1999
1DHN
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1.65 ANGSTROM RESOLUTION STRUCTURE OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS
Descriptor:7,8-DIHYDRONEOPTERIN ALDOLASE
Authors:Hennig, M., D'Arcy, A., Hampele, I.C., Page, M.G.P., Oefner, C.H., Dale, G.
Deposit date:1998-03-31
Release date:1999-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus.
Nat.Struct.Biol., 5, 1998
1DMT
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STRUCTURE OF HUMAN NEUTRAL ENDOPEPTIDASE COMPLEXED WITH PHOSPHORAMIDON
Descriptor:NEUTRAL ENDOPEPTIDASE, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Oefner, C., D'Arcy, A., Hennig, M., Winkler, F.K., Dale, G.E.
Deposit date:1999-12-15
Release date:2000-12-20
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon.
J.Mol.Biol., 296, 2000
1DRF
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CRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE
Descriptor:DIHYDROFOLATE REDUCTASE, SULFATE ION, FOLIC ACID
Authors:Oefner, C., D'Arcy, A., Winkler, F.K.
Deposit date:1990-08-09
Release date:1992-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human dihydrofolate reductase complexed with folate.
Eur.J.Biochem., 174, 1988
1F97
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SOLUBLE PART OF THE JUNCTION ADHESION MOLECULE FROM MOUSE
Descriptor:JUNCTION ADHESION MOLECULE, MAGNESIUM ION
Authors:Kostrewa, D., Brockhaus, M., D'Arcy, A., Dale, G., Bazzoni, G., Dejana, E., Winkler, F., Hennig, M.
Deposit date:2000-07-07
Release date:2001-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray structure of junctional adhesion molecule: structural basis for homophilic adhesion via a novel dimerization motif.
EMBO J., 20, 2001
1FG9
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3:1 COMPLEX OF INTERFERON-GAMMA RECEPTOR WITH INTERFERON-GAMMA DIMER
Descriptor:INTERFERON GAMMA, INTERFERON-GAMMA RECEPTOR ALPHA CHAIN
Authors:Thiel, D.J., le Du, M.-H., Walter, R.L., D'Arcy, A., Chene, C., Fountoulakis, M., Garotta, G., Winkler, F.K., Ealick, S.E.
Deposit date:2000-07-28
Release date:2000-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex.
Structure Fold.Des., 8, 2000
1FR1
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REFINED CRYSTAL STRUCTURE OF BETA-LACTAMASE FROM CITROBACTER FREUNDII INDICATES A MECHANISM FOR BETA-LACTAM HYDROLYSIS
Descriptor:BETA-LACTAMASE
Authors:Oefner, C., D'Arcy, A., Daly, J.J., Winkler, F.K.
Deposit date:2000-09-07
Release date:2001-01-17
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Refined crystal structure of beta-lactamase from Citrobacter freundii indicates a mechanism for beta-lactam hydrolysis.
Nature, 343, 1990
1FR6
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REFINED CRYSTAL STRUCTURE OF BETA-LACTAMASE FROM CITROBACTER FREUNDII INDICATES A MECHANISM FOR BETA-LACTAM HYDROLYSIS
Descriptor:BETA-LACTAMASE, 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid
Authors:Oefner, C., D'Arcy, A., Daly, J.J., Winkler, F.K.
Deposit date:2000-09-07
Release date:2001-01-17
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Refined crystal structure of beta-lactamase from Citrobacter freundii indicates a mechanism for beta-lactam hydrolysis.
Nature, 343, 1990
1G95
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CRYSTAL STRUCTURE OF S.PNEUMONIAE GLMU, APO FORM
Descriptor:N-ACETYLGLUCOSAMINE-1-PHOSPHATE URIDYLTRANSFERASE
Authors:Kostrewa, D., D'Arcy, A., Kamber, M.
Deposit date:2000-11-22
Release date:2001-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Crystal structures of Streptococcus pneumoniae N-acetylglucosamine-1-phosphate uridyltransferase, GlmU, in apo form at 2.33 A resolution and in complex with UDP-N-acetylglucosamine and Mg(2+) at 1.96 A resolution.
J.Mol.Biol., 305, 2001
1G97
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S.PNEUMONIAE GLMU COMPLEXED WITH UDP-N-ACETYLGLUCOSAMINE AND MG2+
Descriptor:N-ACETYLGLUCOSAMINE-1-PHOSPHATE URIDYLTRANSFERASE, MAGNESIUM ION, SODIUM ION, ...
Authors:Kostrewa, D., D'Arcy, A., Kamber, M.
Deposit date:2000-11-22
Release date:2001-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal structures of Streptococcus pneumoniae N-acetylglucosamine-1-phosphate uridyltransferase, GlmU, in apo form at 2.33 A resolution and in complex with UDP-N-acetylglucosamine and Mg(2+) at 1.96 A resolution.
J.Mol.Biol., 305, 2001
1IYK
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CRYSTAL STRUCTURE OF CANDIDA ALBICANS N-MYRISTOYLTRANSFERASE WITH MYRISTOYL-COA AND PEPTIDIC INHIBITOR
Descriptor:MYRISTOYL-COA:PROTEIN N-MYRISTOYLTRANSFERASE, TETRADECANOYL-COA, [CYCLOHEXYLETHYL]-[[[[4-[2-METHYL-1-IMIDAZOLYL-BUTYL]PHENYL]ACETYL]-SERYL]-LYSINYL]-AMINE
Authors:Sogabe, S., Fukami, T.A., Morikami, K., Shiratori, Y., Aoki, Y., D'Arcy, A., Winkler, F.K., Banner, D.W., Ohtsuka, T.
Deposit date:2002-08-29
Release date:2002-12-30
Last modified:2011-11-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of Candida albicans N-Myristoyltransferase with Two Distinct Inhibitors
CHEM.BIOL., 9, 2002
1IYL
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CRYSTAL STRUCTURE OF CANDIDA ALBICANS N-MYRISTOYLTRANSFERASE WITH NON-PEPTIDIC INHIBITOR
Descriptor:Myristoyl-CoA:Protein N-Myristoyltransferase, (1-METHYL-1H-IMIDAZOL-2-YL)-(3-METHYL-4-{3-[(PYRIDIN-3-YLMETHYL)-AMINO]-PROPOXY}-BENZOFURAN-2-YL)-METHANONE
Authors:Sogabe, S., Fukami, T.A., Morikami, K., Shiratori, Y., Aoki, Y., D'Arcy, A., Winkler, F.K., Banner, D.W., Ohtsuka, T.
Deposit date:2002-08-29
Release date:2002-12-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal Structures of Candida albicans N-Myristoyltransferase with Two Distinct Inhibitors
CHEM.BIOL., 9, 2002
1KLI
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COFACTOR-AND SUBSTRATE-ASSISTED ACTIVATION OF FACTOR VIIA
Descriptor:factor VIIa, SULFATE ION, CALCIUM ION, ...
Authors:Sichler, K., Banner, D.W., D'Arcy, A., Hopfner, K.P., Huber, R., Bode, W., Kresse, G.B., Kopetzki, E., Brandstetter, H.
Deposit date:2001-12-12
Release date:2002-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Crystal Structure of Uninhibited Factor VIIa Link its Cofactor and Substrate-assisted Activation to Specific Interactions
J.Mol.Biol., 322, 2002
1KLJ
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CRYSTAL STRUCTURE OF UNINHIBITED FACTOR VIIA
Descriptor:factor VIIa, CALCIUM ION, 1,2-ETHANEDIOL
Authors:Sichler, K., Banner, D., D'Arcy, A., Hopfner, K.P., Huber, R., Bode, W., Kresse, G.B., Kopetzki, E., Brandstetter, H.
Deposit date:2001-12-12
Release date:2002-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions.
J.Mol.Biol., 322, 2002
1QFX
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PH 2.5 ACID PHOSPHATASE FROM ASPERGILLUS NIGER
Descriptor:PROTEIN (PH 2.5 ACID PHOSPHATASE), N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Kostrewa, D., Wyss, M., D'Arcy, A., Van Loon, A.P.G.M.
Deposit date:1999-04-15
Release date:2000-04-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of Aspergillus niger pH 2.5 acid phosphatase at 2. 4 A resolution.
J.Mol.Biol., 288, 1999
1W2K
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TF7A_4380 COMPLEX
Descriptor:BLOOD COAGULATION FACTOR VIIA, TISSUE FACTOR, (2R)-2-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO)-N-BENZYL-2-(3,4-DIMETHOXYPHENYL)ACETAMIDE, ...
Authors:Banner, D.W., D'Arcy, A., Groebke-Zbinden, K., Ackermann, J., Kirchhofer, D., Ji, Y.-H., Tschopp, T.B., Wallbaum, S., Weber, L.
Deposit date:2004-07-06
Release date:2005-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Design of Selective Phenylglycine Amide Tissue Factor/Factor Viia Inhibitors
Bioorg.Med.Chem.Lett., 15, 2005
2DHN
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COMPLEX OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS WITH 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 2.2 A RESOLUTION
Descriptor:7,8-DIHYDRONEOPTERIN ALDOLASE, 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE
Authors:Hennig, M., D'Arcy, A., Hampele, I.C., Page, M.G.P., Oefner, C.H., Dale, G.
Deposit date:1998-03-31
Release date:1999-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus.
Nat.Struct.Biol., 5, 1998
2FOM
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DENGUE VIRUS NS2B/NS3 PROTEASE
Descriptor:polyprotein, CHLORIDE ION, GLYCEROL
Authors:Schiering, N., Kroemer, M., Renatus, M., Erbel, P., D'Arcy, A.
Deposit date:2006-01-13
Release date:2006-03-07
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.
Nat.Struct.Mol.Biol., 13, 2006
2FP7
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WEST NILE VIRUS NS2B/NS3PROTEASE IN COMPLEX WITH BZ-NLE-LYS-ARG-ARG-H
Descriptor:Genome polyprotein, N-benzoyl-L-norleucyl-L-lysyl-N-[(2S)-5-carbamimidamido-1-hydroxypentan-2-yl]-L-argininamide
Authors:Schiering, N., D'Arcy, A., Erbel, P.
Deposit date:2006-01-16
Release date:2006-03-07
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.
Nat.Struct.Mol.Biol., 13, 2006
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