Author results

4IQM
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PUS1
Descriptor:tRNA pseudouridine synthase A, mitochondrial
Authors:Czudnochowski, N., Finer-Moore, J.S., Stroud, R.M.
Deposit date:2013-01-11
Release date:2013-06-05
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:In Human Pseudouridine Synthase 1 (hPus1), a C-Terminal Helical Insert Blocks tRNA from Binding in the Same Orientation as in the Pus1 Bacterial Homologue TruA, Consistent with Their Different Target Selectivities.
J.Mol.Biol., 425, 2013
4ITS
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PUS1 WITH MES IN THE ACTIVE SITE
Descriptor:tRNA pseudouridine synthase A, mitochondrial, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Czudnochowski, N., Finer-Moore, J.S., Stroud, R.M.
Deposit date:2013-01-18
Release date:2013-06-05
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:In Human Pseudouridine Synthase 1 (hPus1), a C-Terminal Helical Insert Blocks tRNA from Binding in the Same Orientation as in the Pus1 Bacterial Homologue TruA, Consistent with Their Different Target Selectivities.
J.Mol.Biol., 425, 2013
4J37
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PUS1
Descriptor:tRNA pseudouridine synthase A, mitochondrial, SULFATE ION, ...
Authors:Czudnochowski, N., Finer-Moore, J.S., Stroud, R.M.
Deposit date:2013-02-05
Release date:2013-06-05
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:In Human Pseudouridine Synthase 1 (hPus1), a C-Terminal Helical Insert Blocks tRNA from Binding in the Same Orientation as in the Pus1 Bacterial Homologue TruA, Consistent with Their Different Target Selectivities.
J.Mol.Biol., 425, 2013
4LAB
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF RLUB
Descriptor:Ribosomal large subunit pseudouridine synthase B, PLATINUM (II) ION, CHLORIDE ION
Authors:Czudnochowski, N., Finer-Moore, J.S., Stroud, R.M.
Deposit date:2013-06-19
Release date:2013-11-20
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.5043 Å)
Cite:The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs.
Nucleic Acids Res., 42, 2014
4LGT
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF RLUB IN COMPLEX WITH A 21-NUCLEOTIDE RNA SUBSTRATE
Descriptor:Ribosomal large subunit pseudouridine synthase B, stem-loop of 23S rRNA
Authors:Czudnochowski, N., Finer-Moore, J.S., Stroud, R.M.
Deposit date:2013-06-28
Release date:2013-11-20
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs.
Nucleic Acids Res., 42, 2014
7JV2
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SARS-COV-2 SPIKE IN COMPLEX WITH THE S2H13 NEUTRALIZING ANTIBODY FAB FRAGMENT (LOCAL REFINEMENT OF THE RECEPTOR-BINDING MOTIF AND FAB VARIABLE DOMAINS)
Descriptor:S2H13 Fab heavy chain, S2H13 Fab light chain, SARS-CoV-2 spike glycoprotein
Authors:Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D.
Deposit date:2020-08-20
Release date:2020-10-14
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Cell(Cambridge,Mass.), 2020
7JV4
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SARS-COV-2 SPIKE IN COMPLEX WITH THE S2H13 NEUTRALIZING ANTIBODY (ONE RBD OPEN)
Descriptor:SARS-CoV-2 spike glycoprotein, S2H13 Fab heavy chain, S2H13 Fab light chain, ...
Authors:Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D.
Deposit date:2020-08-20
Release date:2020-10-14
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Cell(Cambridge,Mass.), 2020
7JV6
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SARS-COV-2 SPIKE IN COMPLEX WITH THE S2H13 NEUTRALIZING ANTIBODY (CLOSED CONFORMATION)
Descriptor:SARS-CoV-2 spike glycoprotein, S2H13 Fab heavy chain, S2H13 Fab light chain, ...
Authors:Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D.
Deposit date:2020-08-20
Release date:2020-10-14
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Cell(Cambridge,Mass.), 2020
7JVA
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SARS-COV-2 SPIKE IN COMPLEX WITH THE S2A4 NEUTRALIZING ANTIBODY FAB FRAGMENT (LOCAL REFINEMENT OF THE RECEPTOR-BINDING DOMAIN AND FAB VARIABLE DOMAINS)
Descriptor:S2A4 Fab heavy chain, S2A4 Fab light chain, SARS-CoV-2 spike glycoprotein, ...
Authors:Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D.
Deposit date:2020-08-20
Release date:2020-10-14
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Cell(Cambridge,Mass.), 2020
7JVC
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SARS-COV-2 SPIKE IN COMPLEX WITH THE S2A4 NEUTRALIZING ANTIBODY FAB FRAGMENT
Descriptor:SARS-CoV-2 spike glycoprotein, S2A4 Fab heavy chain, S2A4 Fab light chain, ...
Authors:Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D.
Deposit date:2020-08-20
Release date:2020-10-14
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Cell(Cambridge,Mass.), 2020
7JW0
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SARS-COV-2 SPIKE IN COMPLEX WITH THE S304 NEUTRALIZING ANTIBODY FAB FRAGMENT
Descriptor:SARS-CoV-2 spike glycoprotein, S304 Fab light chain, S304 Fab heavy chain, ...
Authors:Walls, A.C., Park, Y.J., Tortorici, M.A., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D.
Deposit date:2020-08-24
Release date:2020-10-14
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Cell(Cambridge,Mass.), 2020
7JX3
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MAPPING NEUTRALIZING AND IMMUNODOMINANT SITES ON THE SARS-COV-2 SPIKE RECEPTOR-BINDING DOMAIN BY STRUCTURE-GUIDED HIGH-RESOLUTION SEROLOGY
Descriptor:Light chain of Fab domain of monoclonal antibody S309, Heavy chain of Fab domain of monoclonal antibody S309, Light chain of Fab domain of monoclonal antibody S2H14, ...
Authors:Snell, G., Czudnochowski, N., Rosen, L.E., Nix, J.C., Corti, D., Veesler, D., Park, Y.J., Walls, A.C., Tortorici, M.A., Cameroni, E., Pinto, D., Beltramello, M.
Deposit date:2020-08-26
Release date:2020-10-14
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Cell(Cambridge,Mass.), 2020
7JXC
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MAPPING NEUTRALIZING AND IMMUNODOMINANT SITES ON THE SARS-COV-2 SPIKE RECEPTOR-BINDING DOMAIN BY STRUCTURE-GUIDED HIGH-RESOLUTION SEROLOGY
Descriptor:S2H14 antigen-binding (Fab) fragment, NONAETHYLENE GLYCOL
Authors:Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D.
Deposit date:2020-08-27
Release date:2020-10-14
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Cell(Cambridge,Mass.), 2020
7JXD
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MAPPING NEUTRALIZING AND IMMUNODOMINANT SITES ON THE SARS-COV-2 SPIKE RECEPTOR-BINDING DOMAIN BY STRUCTURE-GUIDED HIGH-RESOLUTION SEROLOGY
Descriptor:S2A4 antigen-binding (Fab) fragment
Authors:Park, Y.J., Tortorici, M.A., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D.
Deposit date:2020-08-27
Release date:2020-10-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Cell(Cambridge,Mass.), 2020
7JXE
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MAPPING NEUTRALIZING AND IMMUNODOMINANT SITES ON THE SARS-COV-2 SPIKE RECEPTOR-BINDING DOMAIN BY STRUCTURE-GUIDED HIGH-RESOLUTION SEROLOGY
Descriptor:S2X35 antigen-binding (Fab) fragment
Authors:Tortorici, M.A., Park, Y.J., Walls, A.C., Czudnochowski, N., Seattle Structural Genomics Center for Infectious Disease (SSGCID), Snell, G., Veesler, D.
Deposit date:2020-08-27
Release date:2020-10-14
Method:X-RAY DIFFRACTION (2.043 Å)
Cite:Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Cell(Cambridge,Mass.), 2020
7K3Q
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AN ULTRA-POTENT HUMAN NEUTRALIZING ANTIBODY LOCKS THE SARS-COV-2 SPIKE IN THE CLOSED CONFORMATION
Descriptor:Fab fragment of S2E12 monoclonal antibody, heavy chain, light chain, ...
Authors:Snell, G., Czudnochowski, N., Ng, C.
Deposit date:2020-09-12
Release date:2020-10-07
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms.
Science, 2020
5CCB
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CRYSTAL STRUCTURE OF HUMAN M1A58 METHYLTRANSFERASE IN A COMPLEX WITH TRNA3LYS AND SAH
Descriptor:tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A, tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6, tRNA3Lys, ...
Authors:Finer-Moore, J., Czudnochowski, N., O'Connell III, J.D., Wang, A.L., Stroud, R.M.
Deposit date:2015-07-01
Release date:2015-11-04
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target.
J.Mol.Biol., 427, 2015
5CCX
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STRUCTURE OF THE PRODUCT COMPLEX OF TRNA M1A58 METHYLTRANSFERASE WITH TRNA3LYS AS SUBSTRATE
Descriptor:tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A, tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6, tRNA3Lys, ...
Authors:Finer-Moore, J., Czudnochowski, N., O'Connell III, J.D., Wang, A.L., Stroud, R.M.
Deposit date:2015-07-02
Release date:2015-11-04
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target.
J.Mol.Biol., 427, 2015
5CD1
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STRUCTURE OF AN ASYMMETRIC TETRAMER OF HUMAN TRNA M1A58 METHYLTRANSFERASE IN A COMPLEX WITH SAH AND TRNA3LYS
Descriptor:tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A, tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6, tRNA3Lys, ...
Authors:Finer-Moore, J., Czudnochowski, N., O'Connell III, J.D., Wang, A.L., Stroud, R.M.
Deposit date:2015-07-02
Release date:2015-11-04
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target.
J.Mol.Biol., 427, 2015
5TP1
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THE STRUCTURE OF THE C-TERMINUS OF VIRULENCE PROTEIN INCE FROM CHLAMYDIA TRACHOMATIS BOUND TO MUS MUSCULUS SNX5-PX DOMAIN
Descriptor:Sorting nexin-5, Inclusion membrane protein E
Authors:Rosenberg, O., Czudnochowski, N.
Deposit date:2016-10-19
Release date:2017-08-30
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction.
Elife, 6, 2017
6UMM
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A COMPLETE STRUCTURE OF THE ESX-3 TRANSLOCON COMPLEX
Descriptor:ESX-3 secretion system protein EccE3, ESX-3 secretion system protein EccD3, ESX-3 secretion system ATPase EccB3, ...
Authors:Poweleit, N., Rosenberg, O.S.
Deposit date:2019-10-09
Release date:2019-10-23
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:A large inner membrane pore defines the ESX translocon
To Be Published
7K43
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SARS-COV-2 SPIKE IN COMPLEX WITH THE S2M11 NEUTRALIZING ANTIBODY FAB FRAGMENT
Descriptor:SARS-CoV-2 spike glycoprotein, S2M11 Fab fragment (heavy chain), S2M11 Fab fragment (light chain), ...
Authors:Tortorici, M.A., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-09-14
Release date:2020-10-07
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms.
Science, 2020
7K45
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SARS-COV-2 SPIKE IN COMPLEX WITH THE S2E12 NEUTRALIZING ANTIBODY FAB FRAGMENT (LOCAL REFINEMENT OF THE RBD AND FAB VARIABLE DOMAINS)
Descriptor:S2E12 neutralizing antibody Fab fragment (heavy chain), S2E12 neutralizing antibody Fab fragment (light chain), Spike glycoprotein, ...
Authors:Tortorici, M.A., Veesler, D.
Deposit date:2020-09-14
Release date:2020-10-07
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms.
Science, 2020
7K4N
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SARS-COV-2 SPIKE IN COMPLEX WITH THE S2E12 NEUTRALIZING ANTIBODY FAB FRAGMENT
Descriptor:Spike glycoprotein, S2E12 neutralizing antibody Fab fragment (heavy chain), S2E12 neutralizing antibody Fab fragment (light chain), ...
Authors:Tortorici, M., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-09-15
Release date:2020-10-07
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms.
Science, 2020
170172
PDB entries from 2020-10-21