Author results

4LBM
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CRD IN COMPLEX WITH LNT
Descriptor:Galectin-3, BETA-D-GLUCOSE, BETA-D-GALACTOSE, ...
Authors:Collins, P.M., Blanchard, H.
Deposit date:2013-06-20
Release date:2014-01-22
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Galectin-3 interactions with glycosphingolipids.
J.Mol.Biol., 426, 2014
4LBN
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CRD IN COMPLEX WITH LNNT
Descriptor:Galectin-3, ALPHA-D-GLUCOSE, BETA-D-GALACTOSE, ...
Authors:Collins, P.M., Blanchard, H.
Deposit date:2013-06-20
Release date:2014-01-22
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Galectin-3 interactions with glycosphingolipids.
J.Mol.Biol., 426, 2014
4LBO
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CRD IN COMPLEX WITH A-GM3
Descriptor:Galectin-3, CHLORIDE ION, BETA-D-GLUCOSE, ...
Authors:Collins, P.M., Blanchard, H.
Deposit date:2013-06-20
Release date:2014-01-22
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Galectin-3 interactions with glycosphingolipids.
J.Mol.Biol., 426, 2014
2NMN
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CARBOHYDRATE-RECOGNISING DOMAIN AT 2.45 ANGSTROM RESOLUTION
Descriptor:Galectin-3, BETA-D-GALACTOSE, BETA-D-GLUCOSE
Authors:Blanchard, H., Collins, P.M.
Deposit date:2006-10-23
Release date:2007-03-06
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Slow diffusion of lactose out of galectin-3 crystals monitored by X-ray crystallography: possible implications for ligand-exchange protocols.
Acta Crystallogr.,Sect.D, 63, 2007
2NMO
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CARBOHYDRATE-RECOGNITION DOMAIN AT 1.35 ANGSTROM RESOLUTION
Descriptor:Galectin-3, BETA-D-GALACTOSE, BETA-D-GLUCOSE, ...
Authors:Blanchard, H., Collins, P.M.
Deposit date:2006-10-23
Release date:2007-03-06
Last modified:2020-07-01
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Slow diffusion of lactose out of galectin-3 crystals monitored by X-ray crystallography: possible implications for ligand-exchange protocols
Acta Crystallogr.,Sect.D, 63, 2007
2NN8
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CARBOHYDRATE-RECOGNITION DOMAIN WITH LACTOSE BOUND, AT 1.35 ANGSTROM RESOLUTION
Descriptor:Galectin-3, BETA-LACTOSE, ALPHA-LACTOSE, ...
Authors:Blanchard, H., Collins, P.M.
Deposit date:2006-10-24
Release date:2007-03-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Slow diffusion of lactose out of galectin-3 crystals monitored by X-ray crystallography: possible implications for ligand-exchange protocols.
Acta Crystallogr.,Sect.D, 63, 2007
3T1L
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 IN COMPLEX WITH METHYL 2-O-ACETYL-3-O-TOLUOYL-BETA-D-TALOPYRANOSIDE
Descriptor:Galectin-3, CHLORIDE ION, methyl 2-O-acetyl-3-O-(4-methylbenzoyl)-beta-D-talopyranoside
Authors:Blanchard, H., Collins, P.M.
Deposit date:2011-07-22
Release date:2011-12-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Taloside inhibitors of galectin-1 and galectin-3
Chem.Biol.Drug Des., 79, 2012
3T1M
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN IN COMPLEX WITH METHYL 3-DEOXY-2-O-TOLUOYL-3-N-TOLUOYL-BETA-D-TALOPYRANOSIDE
Descriptor:Galectin-3, CHLORIDE ION, methyl 3-deoxy-2-O-(4-methylbenzoyl)-3-[(4-methylbenzoyl)amino]-beta-D-talopyranoside
Authors:Blanchard, H., Collins, P.M.
Deposit date:2011-07-22
Release date:2011-12-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Taloside inhibitors of galectin-1 and galectin-3
Chem.Biol.Drug Des., 79, 2012
3T2T
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-1 IN COMPLEX WITH METHYL 2-O-ACETYL-3-O-TOLUOYL-BETA-D-TALOPYRANOSIDE
Descriptor:Galectin-1, methyl 2-O-acetyl-3-O-(4-methylbenzoyl)-beta-D-talopyranoside
Authors:Blanchard, H., Collins, P.M.
Deposit date:2011-07-23
Release date:2011-12-28
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Taloside inhibitors of galectin-1 and galectin-3
Chem.Biol.Drug Des., 79, 2012
4JC1
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GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN IN COMPLEX WITH THIODIGALACTOSIDE
Descriptor:Galectin-3, CHLORIDE ION, THIODIGALACTOSIDE
Authors:Collins, P.M., Blanchard, H.
Deposit date:2013-02-21
Release date:2013-07-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Investigation into the feasibility of thioditaloside as a novel scaffold for galectin-3-specific inhibitors.
Chembiochem, 14, 2013
6EW3
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CRYSTAL STRUCTURE OF THE METALLO-BETA-LACTAMASE VIM-2 WITH ML302F
Descriptor:Metallo-beta-lactamase VIM-2, ZINC ION, FORMIC ACID, ...
Authors:Collins, P.M., Brem, J., McDonough, M.A., van Berkel, S.S., von Delft, F., Schofield, C.J.
Deposit date:2017-11-03
Release date:2018-10-03
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-beta-lactamases.
Bioorg. Med. Chem., 26, 2018
6F83
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-1 IN COMPLEX WITH THIENYL-1,2, 3-TRIAZOLYL THIODIGALACTOSIDE INHIBITOR
Descriptor:Galectin-1, 3-deoxy-3-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-1-thio-3-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranoside
Authors:Collins, P.M., Blanchard, H.
Deposit date:2017-12-12
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands
To be published
3OY8
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-1 IN COMPLEX WITH LACTOBIONIC ACID
Descriptor:Galectin-1, BETA-D-GALACTOSE, GLUCONIC ACID
Authors:Blanchard, H., Collins, P.M.
Deposit date:2010-09-23
Release date:2010-11-03
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model
CANCER LETT., 2010
3OYW
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-1 IN COMPLEX WITH THIODIGALACTOSIDE
Descriptor:Galectin-1, THIODIGALACTOSIDE
Authors:Blanchard, H., Collins, P.M.
Deposit date:2010-09-23
Release date:2010-11-03
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model
CANCER LETT., 2010
5ORL
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CRYSTAL STRUCTURE OF AURORA-A KINASE IN COMPLEX WITH AN ALLOSTERICALLY BINDING FRAGMENT
Descriptor:Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:McIntyre, P.J., Collins, P.M., Vrzal, L., Birchall, K., Arnold, L.H., Mpamhanga, C., Coombs, P.J., Burgess, S.G., Richards, M.W., Winter, A., Veverka, V., von Delft, F., Merritt, A., Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORN
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CRYSTAL STRUCTURE OF AURORA-A KINASE IN COMPLEX WITH AN ALLOSTERICALLY BINDING FRAGMENT
Descriptor:Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:McIntyre, P.J., Collins, P.M., von Delft, F., Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORO
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CRYSTAL STRUCTURE OF AURORA-A KINASE IN COMPLEX WITH AN ALLOSTERICALLY BINDING FRAGMENT
Descriptor:Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:McIntyre, P.J., Collins, P.M., von Delft, F., Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORP
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CRYSTAL STRUCTURE OF AURORA-A KINASE IN COMPLEX WITH AN ALLOSTERICALLY BINDING FRAGMENT
Descriptor:Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:McIntyre, P.J., Collins, P.M., von Delft, F., Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORR
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CRYSTAL STRUCTURE OF AURORA-A KINASE IN COMPLEX WITH AN ALLOSTERICALLY BINDING FRAGMENT
Descriptor:Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:McIntyre, P.J., Collins, P.M., von Delft, F., Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORS
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CRYSTAL STRUCTURE OF AURORA-A KINASE IN COMPLEX WITH AN ALLOSTERICALLY BINDING FRAGMENT
Descriptor:Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:McIntyre, P.J., Collins, P.M., von Delft, F., Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORT
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CRYSTAL STRUCTURE OF AURORA-A KINASE IN COMPLEX WITH AN ALLOSTERICALLY BINDING FRAGMENT
Descriptor:Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:McIntyre, P.J., Collins, P.M., von Delft, F., Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORV
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CRYSTAL STRUCTURE OF AURORA-A KINASE IN COMPLEX WITH AN ALLOSTERICALLY BINDING FRAGMENT
Descriptor:Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:McIntyre, P.J., Collins, P.M., von Delft, F., Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORW
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CRYSTAL STRUCTURE OF AURORA-A KINASE IN COMPLEX WITH AN ALLOSTERICALLY BINDING FRAGMENT
Descriptor:Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:McIntyre, P.J., Collins, P.M., von Delft, F., Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORX
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CRYSTAL STRUCTURE OF AURORA-A KINASE IN COMPLEX WITH AN ALLOSTERICALLY BINDING FRAGMENT
Descriptor:Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:McIntyre, P.J., Collins, P.M., von Delft, F., Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORY
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CRYSTAL STRUCTURE OF AURORA-A KINASE IN COMPLEX WITH AN ALLOSTERICALLY BINDING FRAGMENT
Descriptor:Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:McIntyre, P.J., Collins, P.M., von Delft, F., Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
166594
PDB entries from 2020-07-15