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5ORN

Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment

Summary for 5ORN
Entry DOI10.2210/pdb5orn/pdb
DescriptorAurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordskinase, allosteric inhibitor, fragment, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
Total number of polymer chains1
Total formula weight31454.27
Authors
McIntyre, P.J.,Collins, P.M.,von Delft, F.,Bayliss, R. (deposition date: 2017-08-16, release date: 2017-11-01, Last modification date: 2017-11-29)
Primary citationMcIntyre, P.J.,Collins, P.M.,Vrzal, L.,Birchall, K.,Arnold, L.H.,Mpamhanga, C.,Coombs, P.J.,Burgess, S.G.,Richards, M.W.,Winter, A.,Veverka, V.,Delft, F.V.,Merritt, A.,Bayliss, R.
Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12:2906-2914, 2017
Cited by
PubMed: 29045126
DOI: 10.1021/acschembio.7b00537
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.19 Å)
Structure validation

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