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4E3D
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NUCLEOPHILE RECOGNITION AS AN ALTERNATIVE INHIBITION MODE FOR BENZOIC ACID BASED CARBONIC ANHYDRASE INHIBITORS
Descriptor:Carbonic anhydrase 2, ZINC ION, MERCURIBENZOIC ACID, ...
Authors:Cohen, S.M.
Deposit date:2012-03-09
Release date:2012-06-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
Chem.Commun.(Camb.), 48, 2012
4E3F
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NUCLEOPHILE RECOGNITION AS AN ALTERNATIVE INHIBITION MODE FOR BENZOIC ACID BASED CARBONIC ANHYDRASE INHIBITORS
Descriptor:Carbonic anhydrase 2, ZINC ION, MERCURIBENZOIC ACID, ...
Authors:Cohen, S.M., Martin, D.P.
Deposit date:2012-03-09
Release date:2012-06-27
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
Chem.Commun.(Camb.), 48, 2012
4E3G
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NUCLEOPHILE RECOGNITION AS AN ALTERNATIVE INHIBITION MODE FOR BENZOIC ACID BASED CARBONIC ANHYDRASE INHIBITORS
Descriptor:Carbonic anhydrase 2, ZINC ION, MERCURIBENZOIC ACID, ...
Authors:Cohen, S.M., Martin, D.P.
Deposit date:2012-03-09
Release date:2012-06-27
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
Chem.Commun.(Camb.), 48, 2012
4E3H
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NUCLEOPHILE RECOGNITION AS AN ALTERNATIVE INHIBITION MODE FOR BENZOIC ACID BASED CARBONIC ANHYDRASE INHIBITORS
Descriptor:Carbonic anhydrase 2, ZINC ION, MERCURIBENZOIC ACID, ...
Authors:Cohen, S.M., Martin, D.P.
Deposit date:2012-03-09
Release date:2012-06-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
Chem.Commun.(Camb.), 48, 2012
4E49
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NUCLEOPHILE RECOGNITION AS AN ALTERNATIVE INHIBITION MODE FOR BENZOIC ACID BASED CARBONIC ANHYDRASE INHIBITORS
Descriptor:Carbonic anhydrase 2, ZINC ION, MERCURIBENZOIC ACID, ...
Authors:Cohen, S.M., Martin, D.P.
Deposit date:2012-03-12
Release date:2012-06-27
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
Chem.Commun.(Camb.), 48, 2012
4E4A
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NUCLEOPHILE RECOGNITION AS AN ALTERNATIVE INHIBITION MODE FOR BENZOIC ACID BASED CARBONIC ANHYDRASE INHIBITORS
Descriptor:Carbonic anhydrase 2, ZINC ION, 2-sulfanylbenzoic acid, ...
Authors:Cohen, S.M., Martin, D.P.
Deposit date:2012-03-12
Release date:2012-06-27
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors
Chem.Commun.(Camb.), 48, 2012
1LU5
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2.4 ANGSTROM CRYSTAL STRUCTURE OF THE ASYMMETRIC PLATINUM COMPLEX {PT(AMMINE)(CYCLOHEXYLAMINE)}2+ BOUND TO A DODECAMER DNA DUPLEX
Descriptor:5'-D(*CP*CP*TP*CP*TP*GP*GP*TP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3', CIS-(AMMINE)(CYCLOHEXYLAMINE)PLATINUM(II) COMPLEX
Authors:Silverman, A.P., Bu, W., Cohen, S.M., Lippard, S.J.
Deposit date:2002-05-21
Release date:2002-12-20
Last modified:2012-02-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:2.4-A Crystal Structure of the Asymmetric Platinum Complex {Pt(ammine)(cyclohexylamine)}2+ Bound to a Dodecamer DNA Duplex
J.Biol.Chem., 277, 2002
2J0A
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STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE
Descriptor:BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE, SULFATE ION, POTASSIUM ION
Authors:Jinek, M., Chen, Y.-W., Clausen, H., Cohen, S.M., Conti, E.
Deposit date:2006-08-01
Release date:2006-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Insights Into the Notch-Modifying Glycosyltransferase Fringe
Nat.Struct.Mol.Biol., 13, 2006
2J0B
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STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE IN COMPLEX WITH UDP AND MANGANESE
Descriptor:BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE, SULFATE ION, POTASSIUM ION, ...
Authors:Jinek, M., Chen, Y.-W., Clausen, H., Cohen, S.M., Conti, E.
Deposit date:2006-08-01
Release date:2006-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Insights Into the Notch-Modifying Glycosyltransferase Fringe
Nat.Struct.Mol.Biol., 13, 2006
3HRS
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CRYSTAL STRUCTURE OF THE MANGANESE-ACTIVATED REPRESSOR SCAR: APO FORM
Descriptor:Metalloregulator ScaR, SULFATE ION
Authors:Stoll, K.E., Draper, W.E., Kliegman, J.I., Golynskiy, M.V., Brew-Appiah, R.A.T., Brown, H.K., Breyer, W.A., Jakubovics, N.S., Jenkinson, H.F., Brennan, R.B., Cohen, S.M., Glasfeld, A.
Deposit date:2009-06-09
Release date:2009-06-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Characterization and structure of the manganese-responsive transcriptional regulator ScaR.
Biochemistry, 48, 2009
3HRT
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CRYSTAL STRUCTURE OF SCAR WITH BOUND CD2+
Descriptor:Metalloregulator ScaR, SULFATE ION, CADMIUM ION
Authors:Stoll, K.E., Draper, W.E., Kliegman, J.I., Golynskiy, M.V., Brew-Appiah, R.A.T., Brown, H.K., Breyer, W.A., Jakubovics, N.S., Jenkinson, H.F., Brennan, R.B., Cohen, S.M., Glasfeld, A.
Deposit date:2009-06-09
Release date:2009-06-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Characterization and structure of the manganese-responsive transcriptional regulator ScaR.
Biochemistry, 48, 2009
3HRU
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CRYSTAL STRUCTURE OF SCAR WITH BOUND ZN2+
Descriptor:Metalloregulator ScaR, ZINC ION, SULFATE ION
Authors:Stoll, K.E., Draper, W.E., Kliegman, J.I., Golynskiy, M.V., Brew-Appiah, R.A.T., Brown, H.K., Breyer, W.A., Jakubovics, N.S., Jenkinson, H.F., Brennan, R.B., Cohen, S.M., Glasfeld, A.
Deposit date:2009-06-09
Release date:2009-06-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Characterization and structure of the manganese-responsive transcriptional regulator ScaR.
Biochemistry, 48, 2009
4JS6
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CRYSTAL STRUCTURE OF INHIBITOR-FREE HCAII H94D
Descriptor:Carbonic anhydrase 2, ZINC ION, MERCURIBENZOIC ACID
Authors:Martin, D.P., Hann, Z.S., Cohen, S.M.
Deposit date:2013-03-22
Release date:2013-06-19
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Metalloprotein-Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal-Ligand Interactions in a Metalloprotein Active Site.
Inorg.Chem., 52, 2013
4JSA
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BENZENESULFONAMIDE COMPLEXED WITH HCAII H94D
Descriptor:Carbonic anhydrase 2, ZINC ION, MERCURIBENZOIC ACID, ...
Authors:Martin, D.P., Hann, Z.S., Cohen, S.M.
Deposit date:2013-03-22
Release date:2013-06-19
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Metalloprotein-Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal-Ligand Interactions in a Metalloprotein Active Site.
Inorg.Chem., 52, 2013
4JSS
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HUMAN CARBONIC ANHYDRASE II H94D BOUND TO A BIDENTATE INHIBITOR
Descriptor:Carbonic anhydrase 2, ZINC ION, MERCURIBENZOIC ACID, ...
Authors:Martin, D.P., Hann, Z.S., Cohen, S.M.
Deposit date:2013-03-22
Release date:2013-06-19
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Metalloprotein-Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal-Ligand Interactions in a Metalloprotein Active Site.
Inorg.Chem., 52, 2013
4JSW
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HUMAN CARBONIC ANHYDRASE II H94C
Descriptor:Carbonic anhydrase 2, ZINC ION
Authors:Martin, D.P., Hann, Z.S., Cohen, S.M.
Deposit date:2013-03-22
Release date:2013-06-19
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Metalloprotein-Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal-Ligand Interactions in a Metalloprotein Active Site.
Inorg.Chem., 52, 2013
4JSZ
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BENZENESULFONAMIDE BOUND TO HCAII H94C
Descriptor:Carbonic anhydrase 2, ZINC ION, benzenesulfonamide
Authors:Martin, D.P., Hann, Z.S., Cohen, S.M.
Deposit date:2013-03-22
Release date:2013-06-19
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Metalloprotein-Inhibitor Binding: Human Carbonic Anhydrase II as a Model for Probing Metal-Ligand Interactions in a Metalloprotein Active Site.
Inorg.Chem., 52, 2013
4MLT
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STRUCTURE OF A MONODENTATE 3-HYDROXY-4H-PYRAN-4-THIONE LIGAND BOUND TO HCAII
Descriptor:Carbonic anhydrase 2, ZINC ION, MERCURIBENZOIC ACID, ...
Authors:Martin, D.P., Cohen, S.M.
Deposit date:2013-09-06
Release date:2014-07-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:'Unconventional' coordination chemistry by metal chelating fragments in a metalloprotein active site.
J.Am.Chem.Soc., 136, 2014
4MLX
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STRUCTURE OF A BIDENTATE 3-HYDROXY-4H-PYRAN-4-THIONE LIGAND BOUND TO HCAII
Descriptor:Carbonic anhydrase 2, ZINC ION, MERCURIBENZOIC ACID, ...
Authors:Martin, D.P., Cohen, S.M.
Deposit date:2013-09-06
Release date:2014-07-02
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:'Unconventional' coordination chemistry by metal chelating fragments in a metalloprotein active site.
J.Am.Chem.Soc., 136, 2014
4Q7P
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CRYSTAL STRUCTURE OF 1-HYDROXY-3-METHYLPYRIDINE-2(1H)-THIONE BOUND TO HCAII
Descriptor:Carbonic anhydrase 2, ZINC ION, 1-hydroxy-3-methylpyridine-2(1H)-thione, ...
Authors:Martin, D.P., Cohen, S.M.
Deposit date:2014-04-25
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Exploring the influence of the protein environment on metal-binding pharmacophores.
J.Med.Chem., 57, 2014
4Q7S
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CRYSTAL STRUCTURE OF 1-HYDROXY-4-METHYLPYRIDINE-2(1H)-THIONE BOUND TO HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase 2, ZINC ION, 1-hydroxy-4-methylpyridine-2(1H)-thione, ...
Authors:Martin, D.P., Cohen, S.M.
Deposit date:2014-04-25
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Exploring the influence of the protein environment on metal-binding pharmacophores.
J.Med.Chem., 57, 2014
4Q7V
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CRYSTAL STRUCTURE OF 1-HYDROXY-5-METHYLPYRIDINE-2(1H)-THIONE BOUND TO HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase 2, ZINC ION, 1-hydroxy-5-methylpyridine-2(1H)-thione, ...
Authors:Martin, D.P., Cohen, S.M.
Deposit date:2014-04-25
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Exploring the influence of the protein environment on metal-binding pharmacophores.
J.Med.Chem., 57, 2014
4Q7W
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CRYSTAL STRUCTURE OF 1-HYDROXY-6-METHYLPYRIDINE-2(1H)-THIONE BOUND TO HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase 2, ZINC ION, 1-hydroxy-6-methylpyridine-2(1H)-thione, ...
Authors:Martin, D.P., Cohen, S.M.
Deposit date:2014-04-25
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Exploring the influence of the protein environment on metal-binding pharmacophores.
J.Med.Chem., 57, 2014
4Q81
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CRYSTAL STRUCTURE OF 1-HYDROXY-4,6-DIMETHYLPYRIDINE-2(1H)-THIONE BOUND TO HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ...
Authors:Martin, D.P., Cohen, S.M.
Deposit date:2014-04-25
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Exploring the influence of the protein environment on metal-binding pharmacophores.
J.Med.Chem., 57, 2014
4Q83
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CRYSTAL STRUCTURE OF 1-HYDROXY-3-(TRIFLUOROMETHYL)PYRIDINE-2(1H)-THIONE BOUND TO HUMAN CARBONIC ANHYDRASE II
Descriptor:Carbonic anhydrase 2, ZINC ION, 1-hydroxy-3-(trifluoromethyl)pyridine-2(1H)-thione, ...
Authors:Martin, D.P., Cohen, S.M.
Deposit date:2014-04-25
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Exploring the influence of the protein environment on metal-binding pharmacophores.
J.Med.Chem., 57, 2014
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