Author results

1NI1
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IMIDAZOLE AND CYANOPHENYL FARNESYL TRANSFERASE INHIBITORS
Descriptor:Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ...
Authors:Tong, Y., Lin, N.H., Wang, L., Hasvold, L., Wang, W., Leonard, N., Li, T., Li, Q., Cohen, J., Gu, W.Z., Zhang, H., Stoll, V., Bauch, J., Marsh, K., Rosenberg, S.H., Sham, H.L.
Deposit date:2002-12-20
Release date:2004-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.
Bioorg.Med.Chem.Lett., 13, 2003
1ZUC
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PROGESTERONE RECEPTOR LIGAND BINDING DOMAIN IN COMPLEX WITH THE NONSTEROIDAL AGONIST TANAPROGET
Descriptor:Progesterone receptor, 5-(4,4-DIMETHYL-2-THIOXO-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-6-YL)-1-METHYL-1H-PYRROLE-2-CARBONITRILE, SULFATE ION
Authors:Zhang, Z., Olland, A.M., Zhu, Y., Cohen, J., Berrodin, T., Chippari, S., Appavu, C., Li, S., Wilhem, J., Chopra, R., Fensome, A., Zhang, P., Wrobel, J., Unwalla, R.J., Lyttle, C.R., Winneker, R.C.
Deposit date:2005-05-30
Release date:2005-07-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget
J.Biol.Chem., 280, 2005
1N94
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ARYL TETRAHYDROPYRIDINE INHBITORS OF FARNESYLTRANSFERASE: GLYCINE, PHENYLALANINE AND HISTIDINE DERIVATES
Descriptor:Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID, ...
Authors:Gwaltney II, S.L., O'Connor, S.J., Nelson, L.T., Sullivan, G.M., Imade, H., Wang, W., Hasvold, L., Li, Q., Cohen, J., Gu, W.Z.
Deposit date:2002-11-22
Release date:2003-01-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives.
Bioorg.Med.Chem.Lett., 13, 2003
1N95
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ARYL TETRAHYDROPHYRIDINE INHBITORS OF FARNESYLTRANFERASE: GLYCINE, PHENYLALANINE AND HISTIDINE DERIVATIVES
Descriptor:Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ...
Authors:Gwaltney II, S.L., O'Conner, S.J., Nelson, L.T., Sullivan, G.M., Imade, H., Wang, W., Hasvold, L., Li, Q., Cohen, J., Gu, W.Z.
Deposit date:2002-11-22
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives.
Bioorg.Med.Chem.Lett., 13, 2003
1N9A
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FARNESYLTRANSFERASE COMPLEX WITH TETRAHYDROPYRIDINE INHIBITORS
Descriptor:Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ...
Authors:Gwaltney II, S.L., O'Conner, S.J., Nelson, L.T., Sullivan, G.M., Imade, H., Wang, W., Hasvold, L., Li, Q., Cohen, J., Gu, W.Z.
Deposit date:2002-11-22
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.
Bioorg.Med.Chem.Lett., 13, 2003
1NL4
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CRYSTAL STRUCTURE OF RAT FARNESYL TRANSFERASE IN COMPLEX WITH A POTENT BIPHENYL INHIBITOR
Descriptor:Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ...
Authors:Curtin, M.L., Florjancic, A.S., Cohen, J., Gu, W.-J., Frost, D.J., Muchmore, S.W., Sham, H.L.
Deposit date:2003-01-06
Release date:2003-02-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Novel and Selective Imidazole-containing Biphenyl Inhibitors of Protein Farnesyltransferase
BIOORG.MED.CHEM.LETT., 13, 2003
1X81
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FARNESYL TRANSFERASE STRUCTURE OF JANSEN COMPOUND
Descriptor:Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ...
Authors:Li, Q., Claiborne, A., Li, T., Hasvold, L., Stoll, V.S., Muchmore, S., Jakob, C.G., Gu, W., Cohen, J., Hutchins, C., Frost, D., Rosenberg, S.H., Sham, H.L.
Deposit date:2004-08-16
Release date:2004-12-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.
Bioorg.Med.Chem.Lett., 14, 2004
3G46
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LIGAND MIGRATION AND CAVITIES WITHIN SCAPHARCA DIMERIC HEMOGLOBIN: WILD TYPE WITH CO BOUND TO HEME AND CHLOROFORM BOUND TO THE XE4 CAVITY
Descriptor:Globin-1, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE, ...
Authors:Knapp, J.E., Pahl, R., Cohen, J., Nichols, J.C., Schulten, K., Gibson, Q.H., Srajer, V., Royer Jr., W.E.
Deposit date:2009-02-03
Release date:2009-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.91 Å)
Cite:Ligand migration and cavities within Scapharca Dimeric HbI: studies by time-resolved crystallo-graphy, Xe binding, and computational analysis.
Structure, 17, 2009
3G4Q
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LIGAND MIGRATION AND CAVITIES WITHIN SCAPHARCA DIMERIC HEMOGLOBIN: WILD TYPE WITH CO BOUND TO HEME AND CHLOROFORM BOUND TO THE XE4 CAVITY
Descriptor:Globin-1, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE, ...
Authors:Knapp, J.E., Pahl, R., Cohen, J., Nichols, J.C., Schulten, K., Gibson, Q.H., Srajer, V., Royer Jr., W.E.
Deposit date:2009-02-04
Release date:2009-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Ligand migration and cavities within Scapharca Dimeric HbI: studies by time-resolved crystallo-graphy, Xe binding, and computational analysis.
Structure, 17, 2009
3G4R
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LIGAND MIGRATION AND CAVITIES WITHIN SCAPHARCA DIMERIC HEMOGLOBIN: WILD TYPE WITH CO BOUND TO HEME AND DICHLOROETHANE BOUND TO THE XE4 CAVITY
Descriptor:Globin-1, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE, ...
Authors:Knapp, J.E., Pahl, R., Cohen, J., Nichols, J.C., Schulten, K., Gibson, Q.H., Srajer, V., Royer Jr., W.E.
Deposit date:2009-02-04
Release date:2009-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Ligand migration and cavities within Scapharca Dimeric HbI: studies by time-resolved crystallo-graphy, Xe binding, and computational analysis.
Structure, 17, 2009
3G4U
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LIGAND MIGRATION AND CAVITIES WITHIN SCAPHARCA DIMERIC HEMOGLOBIN: WILD TYPE WITH CO BOUND TO HEME AND DICHLOROPROPANE BOUND TO THE XE4 CAVITY
Descriptor:GLOBIN-1, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE, ...
Authors:Knapp, J.E., Pahl, R., Cohen, J., Nichols, J.C., Schulten, K., Gibson, Q.H., Srajer, V., Royer Jr., W.E.
Deposit date:2009-02-04
Release date:2009-12-01
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Ligand migration and cavities within Scapharca Dimeric HbI: studies by time-resolved crystallo-graphy, Xe binding, and computational analysis.
Structure, 17, 2009
3G4V
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LIGAND MIGRATION AND CAVITIES WITHIN SCAPHARCA DIMERIC HEMOGLOBIN: WILD TYPE WITH CO BOUND TO HEME AND CHLOROPENTANE BOUND TO THE XE4 CAVITY
Descriptor:GLOBIN-1, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE, ...
Authors:Knapp, J.E., Pahl, R., Cohen, J., Nichols, J.C., Schulten, K., Gibson, Q.H., Srajer, V., Royer Jr., W.E.
Deposit date:2009-02-04
Release date:2009-12-01
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Ligand migration and cavities within Scapharca Dimeric HbI: studies by time-resolved crystallo-graphy, Xe binding, and computational analysis.
Structure, 17, 2009
3G4W
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LIGAND MIGRATION AND CAVITIES WITHIN SCAPHARCA DIMERIC HEMOGLOBIN: WILD TYPE WITH CO BOUND TO HEME AND CHLOROBENZENE BOUND TO THE XE4 CAVITY
Descriptor:GLOBIN-1, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE, ...
Authors:Knapp, J.E., Pahl, R., Cohen, J., Nichols, J.C., Schulten, K., Gibson, Q.H., Srajer, V., Royer Jr., W.E.
Deposit date:2009-02-04
Release date:2009-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ligand migration and cavities within Scapharca Dimeric HbI: studies by time-resolved crystallo-graphy, Xe binding, and computational analysis.
Structure, 17, 2009
3G4Y
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LIGAND MIGRATION AND CAVITIES WITHIN SCAPHARCA DIMERIC HEMOGLOBIN: WILD TYPE WITH CO BOUND TO HEME AND CHLOROMETHYL BENZENE BOUND TO THE XE4 CAVITY
Descriptor:GLOBIN-1, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE, ...
Authors:Knapp, J.E., Pahl, R., Cohen, J., Nichols, J.C., Schulten, K., Gibson, Q.H., Srajer, V., Royer Jr., W.E.
Deposit date:2009-02-04
Release date:2009-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Ligand migration and cavities within Scapharca Dimeric HbI: studies by time-resolved crystallo-graphy, Xe binding, and computational analysis.
Structure, 17, 2009
3G52
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LIGAND MIGRATION AND CAVITIES WITHIN SCAPHARCA DIMERIC HEMOGLOBIN: WILD TYPE WITH CO BOUND TO HEME AND CHLOROETHYL BENZENE BOUND TO THE XE4 CAVITY
Descriptor:GLOBIN-1, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE, ...
Authors:Knapp, J.E., Pahl, R., Cohen, J., Nichols, J.C., Schulten, K., Gibson, Q.H., Srajer, V., Royer Jr., W.E.
Deposit date:2009-02-04
Release date:2009-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Ligand migration and cavities within Scapharca Dimeric HbI: studies by time-resolved crystallo-graphy, Xe binding, and computational analysis.
Structure, 17, 2009
3G53
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LIGAND MIGRATION AND CAVITIES WITHIN SCAPHARCA DIMERIC HEMOGLOBIN: WILD TYPE WITH CO BOUND TO HEME AND CHLOROPROPYL BENZENE BOUND TO THE XE4 CAVITY
Descriptor:GLOBIN-1, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE, ...
Authors:Knapp, J.E., Pahl, R., Cohen, J., Nichols, J.C., Schulten, K., Gibson, Q.H., Srajer, V., Royer Jr., W.E.
Deposit date:2009-02-04
Release date:2009-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Ligand migration and cavities within Scapharca Dimeric HbI: studies by time-resolved crystallo-graphy, Xe binding, and computational analysis.
Structure, 17, 2009
1QHD
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CRYSTAL STRUCTURE OF VP6, THE MAJOR CAPSID PROTEIN OF GROUP A ROTAVIRUS
Descriptor:VIRAL CAPSID VP6, ZINC ION, CHLORIDE ION, ...
Authors:Mathieu, M., Petitpas, I., Rey, F.A.
Deposit date:1999-04-29
Release date:2001-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Atomic structure of the major capsid protein of rotavirus: implications for the architecture of the virion.
EMBO J., 20, 2001
2OOV
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CRYSTAL STRUCTURE OF HANSENULA POLYMORPHA AMINE OXIDASE TO 1.7 ANGSTROMS
Descriptor:Peroxisomal copper amine oxidase, COPPER (II) ION, GLYCEROL, ...
Authors:Johnson, B.J., Wilmot, C.M.
Deposit date:2007-01-26
Release date:2007-04-10
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Exploring molecular oxygen pathways in Hansenula polymorpha copper-containing amine oxidase
J.Biol.Chem., 282, 2007
2OQE
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CRYSTAL STRUCTURE OF HANSENULA POLYMORPHA AMINE OXIDASE IN COMPLEX WITH XE TO 1.6 ANGSTROMS
Descriptor:Peroxisomal copper amine oxidase, COPPER (II) ION, XENON, ...
Authors:Johnson, B.J., Wilmot, C.M.
Deposit date:2007-01-31
Release date:2007-04-10
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Exploring molecular oxygen pathways in Hansenula polymorpha copper-containing amine oxidase
J.Biol.Chem., 282, 2007