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2DUW
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SOLUTION STRUCTURE OF PUTATIVE COA-BINDING PROTEIN OF KLEBSIELLA PNEUMONIAE
Descriptor:putative CoA-binding protein
Authors:Hung, K.W., Lin, Y.C., Cheng, C.C., Chang, C.F., Tsai, S.F., Huang, T.H.
Deposit date:2006-07-27
Release date:2007-08-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of putative CoA-binding protein of Klebsiella pneumoniae
To be Published
3JZI
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CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE FROM E. COLI IN COMPLEX WITH BENZIMIDAZOLE SERIES
Descriptor:Biotin carboxylase, 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide
Authors:Cheng, C., Shipps, G.W., Yang, Z., Sun, B., Kawahata, N., Soucy, K., Soriano, A., Orth, P., Xiao, L., Mann, P., Black, T.
Deposit date:2009-09-23
Release date:2009-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Discovery and optimization of antibacterial AccC inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
3JZF
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CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE FROM E. COLI IN COMPLEX WITH BENZIMIDAZOLES SERIES
Descriptor:Biotin carboxylase, CARBONATE ION, 2-[(2-chlorobenzyl)amino]-1-(cyclohexylmethyl)-1H-benzimidazole-5-carboxamide
Authors:Orth, P.
Deposit date:2009-09-23
Release date:2009-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Discovery and optimization of antibacterial AccC inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
3LKH
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INHIBITORS OF HEPATITIS C VIRUS POLYMERASE: SYNTHESIS AND CHARACTERIZATION OF NOVEL 6-FLUORO-N-[2-HYDROXY-1(S)-BENZAMIDES
Descriptor:RNA-directed RNA polymerase, 2-(2-{[(1S)-1-benzyl-2-hydroxyethyl]amino}-2-oxoethoxy)-N-butyl-6-fluoro-N-methylbenzamide
Authors:Lesburg, C.A.
Deposit date:2010-01-27
Release date:2010-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides.
Bioorg.Med.Chem.Lett., 20, 2010
3U9N
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X-RAY CRYSTAL STRUCTURE OF COMPOUND 1 BOUND TO HUMAN CHK1 KINASE DOMAIN
Descriptor:Serine/threonine-protein kinase Chk1, 2-(2,3-dihydro-1-benzofuran-5-yl)-N-[2-(piperazin-1-yl)phenyl]-1,3-thiazole-4-carboxamide
Authors:Fischmann, T.O.
Deposit date:2011-10-19
Release date:2012-01-25
Last modified:2012-02-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Discovery of a Novel Series of CHK1 Kinase Inhibitors with Distinctive Hinge Binding Mode
ACS MED.CHEM.LETT., 2012
4HYH
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X-RAY CRYSTAL STRUCTURE OF COMPOUND 39 BOUND TO HUMAN CHK1 KINASE DOMAIN
Descriptor:Serine/threonine-protein kinase Chk1, 2-(6-methoxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-[4-(piperazin-1-yl)pyridin-3-yl]-1,3-thiazole-4-carboxamide
Authors:Fischmann, T.O.
Deposit date:2012-11-13
Release date:2013-03-06
Last modified:2013-05-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
4HYI
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X-RAY CRYSTAL STRUCTURE OF COMPOUND 40 BOUND TO HUMAN CHK1 KINASE DOMAIN
Descriptor:Serine/threonine-protein kinase Chk1, GLYCEROL, 2-(1H-indazol-1-yl)-N-[2-(piperazin-1-yl)phenyl]-1,3-thiazole-4-carboxamide
Authors:Fischmann, T.O.
Deposit date:2012-11-13
Release date:2013-03-06
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.399 Å)
Cite:Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013