4HYH
X-RAY Crystal structure of compound 39 bound to human chk1 kinase domain
Summary for 4HYH
Entry DOI | 10.2210/pdb4hyh/pdb |
Related | 4HYI |
Descriptor | Serine/threonine-protein kinase Chk1, 2-(6-methoxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-[4-(piperazin-1-yl)pyridin-3-yl]-1,3-thiazole-4-carboxamide (3 entities in total) |
Functional Keywords | serine/threonine-protein kinase chk1 inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O14757 |
Total number of polymer chains | 1 |
Total formula weight | 33493.50 |
Authors | Fischmann, T.O. (deposition date: 2012-11-13, release date: 2013-03-06, Last modification date: 2024-02-28) |
Primary citation | Huang, X.,Cheng, C.C.,Fischmann, T.O.,Duca, J.S.,Richards, M.,Tadikonda, P.K.,Reddy, P.A.,Zhao, L.,Arshad Siddiqui, M.,Parry, D.,Davis, N.,Seghezzi, W.,Wiswell, D.,Shipps, G.W. Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors. Bioorg.Med.Chem.Lett., 23:2590-2594, 2013 Cited by PubMed: 23535330DOI: 10.1016/j.bmcl.2013.02.108 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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